Birgit Deiman
YOU?
Author Swipe
View article: Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select <scp><i>DPYD</i></scp> variant alleles that received <scp><i>DPYD</i></scp> genotype‐guided dosing
Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select <span><i>DPYD</i></span> variant alleles that received <span><i>DPYD</i></span> genotype‐guided dosing Open
DPYD gene variations are associated with severe fluoropyrimidine toxicity, and an initial 50% dose reduction is widely recommended for heterozygous carriers of relevant DPYD variants, including DPYD*2A , DPYD*13 , c.2846A>T, and c.1236G>A.…
View article: External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium Open
Background Identification of tumor-derived variants in circulating tumor DNA (ctDNA) has potential as a sensitive and reliable surrogate for tumor tissue-based routine diagnostic testing. However, variations in pre(analytical) procedures a…
View article: High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment
High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment Open
View article: The Effect of Genotyping on the Number of Pharmacotherapeutic Gene–Drug Interventions in Chronic Kidney Disease Patients
The Effect of Genotyping on the Number of Pharmacotherapeutic Gene–Drug Interventions in Chronic Kidney Disease Patients Open
Patients with chronic kidney disease (CKD) stage 3–5 are polypharmacy patients. Many of these drugs are metabolized by cytochrome P450 (CYP450) and CYP450. Genetic polymorphism is well known to result in altered drug metabolism capacity. T…
View article: Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer
Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer Open
View article: Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancer
Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancer Open
View article: Dutch National Round Robin Trial on Plasma-Derived Circulating Cell-Free DNA Extraction Methods Routinely Used in Clinical Pathology for Molecular Tumor Profiling
Dutch National Round Robin Trial on Plasma-Derived Circulating Cell-Free DNA Extraction Methods Routinely Used in Clinical Pathology for Molecular Tumor Profiling Open
Background Efficient recovery of circulating tumor DNA (ctDNA) depends on the quantity and quality of circulating cell-free DNA (ccfDNA). Here, we evaluated whether various ccfDNA extraction methods routinely applied in Dutch laboratories …
View article: UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients
UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients Open
View article: <scp>Cerebrospinal Fluid</scp> Analysis <scp>Post–COVID</scp>‐19 Is Not Suggestive of Persistent <scp>Central Nervous System</scp> Infection
<span>Cerebrospinal Fluid</span> Analysis <span>Post–COVID</span>‐19 Is Not Suggestive of Persistent <span>Central Nervous System</span> Infection Open
This study was undertaken to assess whether SARS‐CoV‐2 causes a persistent central nervous system infection. SARS‐CoV‐2–specific antibody index and SARS‐CoV‐2 RNA were studied in cerebrospinal fluid following COVID‐19. Cerebrospinal fluid …
View article: Therapy Monitoring of EGFR-Positive Non–Small-Cell Lung Cancer Patients Using ddPCR Multiplex Assays
Therapy Monitoring of EGFR-Positive Non–Small-Cell Lung Cancer Patients Using ddPCR Multiplex Assays Open
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung cancer patients is important for the selection and monitoring of EGFR tyrosine-kinase inhibitor therapy. Droplet digital PCR (ddPCR) multiplex …
View article: Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients
Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients Open
View article: Sensitive cell-free tumor DNA analysis in supernatant pleural effusions supports therapy selection and disease monitoring of lung cancer patients
Sensitive cell-free tumor DNA analysis in supernatant pleural effusions supports therapy selection and disease monitoring of lung cancer patients Open
View article: HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study
HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study Open
View article: Sensitive detection and quantification of SARS-CoV-2 by multiplex droplet digital RT-PCR
Sensitive detection and quantification of SARS-CoV-2 by multiplex droplet digital RT-PCR Open
The purpose of this study is to develop a one-step droplet digital RT-PCR (RT-ddPCR) multiplex assay that allows for sensitive quantification of SARS-CoV-2 RNA with respect to human-derived RNA and could be used for screening and monitorin…
View article: Sensitive Detection and Quantification of SARS-CoV-2 by Multiplex Droplet Digital RT-PCR
Sensitive Detection and Quantification of SARS-CoV-2 by Multiplex Droplet Digital RT-PCR Open
Purpose. We aimed to develop a one-step droplet digital RT-PCR (RT-ddPCR) multiplex assay that allows for sensitive detection of SARS-CoV-2 RNA with respect to human derived RNA and could be used for triage and monitoring of Covid-19 patie…
View article: A unifying model to predict variable drug response for personalised medicine
A unifying model to predict variable drug response for personalised medicine Open
Pharmacogenomics is a key component of personalized medicine. It promises a safer and more effective drug treatment by individualizing the choice of drug and dose based on an individual’s genetic profile 1,2 . The majority of commonly pres…
View article: Optimized (Pre) Analytical Conditions and Workflow for Droplet Digital PCR Analysis of Cell-Free DNA from Patients with Suspected Lung Carcinoma
Optimized (Pre) Analytical Conditions and Workflow for Droplet Digital PCR Analysis of Cell-Free DNA from Patients with Suspected Lung Carcinoma Open
For patients with suspected lung carcinoma, the analysis of circulating tumor DNA, obtained by liquid biopsy, has the potential to support cancer diagnosis and guide targeted therapy. To ensure sensitive and reproducible detection of circu…
View article: High Treatment Uptake in Human Immunodeficiency Virus/Hepatitis C Virus–Coinfected Patients After Unrestricted Access to Direct-Acting Antivirals in the Netherlands
High Treatment Uptake in Human Immunodeficiency Virus/Hepatitis C Virus–Coinfected Patients After Unrestricted Access to Direct-Acting Antivirals in the Netherlands Open
Fifteen months after unrestricted DAA availability the majority of HIV/HCV-coinfected patients in the Netherlands have their HCV infection cured (76%) or are awaiting DAA treatment results (6%). This rapid treatment scale-up may contribute…