Birgit Donner
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View article: QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations
QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations Open
Prolongation of the QT interval in the ECG is a critical finding that signifies an extended duration from the onset of ventricular depolarization to the end of ventricular repolarization. It can predispose patients to life-threatening arrh…
View article: Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy
Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy Open
There is an unmet medical need to treat patients with severe hypertrophic cardiomyopathy leading to heart failure and death in children carrying pathogenic activating variants in the RAS/mitogen-activated protein kinase pathway. A retrospe…
View article: Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial
Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial Open
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry
Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry Open
Aims Calmodulinopathy due to mutations in any of the three CALM genes (CALM1–3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the…
View article: Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial
Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial Open
View article: Apparent life-threatening events and brief resolved unexplained events: management of children at a Swiss tertiary care center
Apparent life-threatening events and brief resolved unexplained events: management of children at a Swiss tertiary care center Open
AIMS OF THE STUDY: Apparent life threatening events (ALTEs) are highly stressful situations for the caregiver and commonly result in presentation of the child to an emergency department. As the events are usually brief and resolve in a sho…
View article: The very low risk of myocarditis and pericarditis after mRNA COVID-19 vaccination should not discourage vaccination
The very low risk of myocarditis and pericarditis after mRNA COVID-19 vaccination should not discourage vaccination Open
The benefits of vaccination – regarding COVID-19 infection and transmission, as well as COVID-associated complications – clearly outweigh the potential risk of vaccine-associated inflammation of the heart and other adverse events. Given th…
View article: Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes
Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes Open
A QTc lengthening effect of nocturnal hypoglycemia in children with T1D was documented. HRV changes occurred even before detection of nocturnal hypoglycemia by CGM, which may be useful for hypoglycemia prediction.
View article: Author response for "Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes"
Author response for "Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes" Open
View article: Intrauterine Growth Retardation in Pregnant Women with Long QT Syndrome Treated with Beta-Receptor Blockers
Intrauterine Growth Retardation in Pregnant Women with Long QT Syndrome Treated with Beta-Receptor Blockers Open
Pregnant women with inherited long QT syndrome (iLQTS) are at an increased risk for preterm delivery and intrauterine growth retardation (IUGR) due to their underlying disease. Additionally, they are at a risk of arrhythmogenic events, par…
View article: Von Minimal-invasiv bis Hybrid – Neue Trends in der Kinderherzchirurgie
Von Minimal-invasiv bis Hybrid – Neue Trends in der Kinderherzchirurgie Open
View article: A variant in<i>MRPS14</i>(uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement
A variant in<i>MRPS14</i>(uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement Open
Dysfunction of mitochondrial translation is an increasingly important molecular cause of human disease, but structural defects of mitochondrial ribosomal subunits are rare. We used next-generation sequencing to identify a homozygous varian…
View article: A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias
A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias Open
Our findings suggest that the presented approach of modified PES enables effective induction and quantification of VA in wildtype mice and may well be suited to document and evaluate detailed VA characteristics in mice.
View article: Kawasaki-Syndrom mit Makrophagenaktivierung bei einem sechsjährigen Mädchen
Kawasaki-Syndrom mit Makrophagenaktivierung bei einem sechsjährigen Mädchen Open
Einleitung und HintergrundDas Kawasaki-Syndrom (KS) ist eine akute febrile Vaskulitis der kleinen und mittelgroßen Arterien.Gefürchtet ist der Befall der Koronararterien (1), der lebensbedrohlich verlaufen kann.Die genaue Ätiopathologie de…
View article: Complicated Postoperative Course after Pulmonary Artery Sling Repair and Slide Tracheoplasty
Complicated Postoperative Course after Pulmonary Artery Sling Repair and Slide Tracheoplasty Open
Pulmonary artery sling (PAS) is a rare congenital condition in which the left pulmonary artery (LPA) arises from the right pulmonary artery, and then passes between the trachea and the esophagus to reach the left lung, thereby forming a sl…
View article: Cardiac magnetic resonance imaging in congential heart disease
Cardiac magnetic resonance imaging in congential heart disease Open
Position paper of a group of Swiss paediatric and adult cardiologists, and radiologists performing cardiac magnetic resonance in congenital heart disease, endorsed by the working groups "Adult Congenital Heart Disease" (WATCH) and "Echocar…
View article: Response to Letter Regarding Article, “Upregulation of K <sub>2P</sub> 3.1 K <sup>+</sup> Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation”
Response to Letter Regarding Article, “Upregulation of K <sub>2P</sub> 3.1 K <sup>+</sup> Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation” Open
View article: Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype
Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype Open
Background/Aims: Pannexin-1 (Panx1) is an ATP release channel that is ubiquitously expressed and coupled to several ligand-gated receptors. In isolated cardiac myocytes, Panx1 forms large conductance channels that can be activated by Ca2+ …
View article: Upregulation of K <sub>2P</sub> 3.1 K <sup>+</sup> Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation
Upregulation of K <sub>2P</sub> 3.1 K <sup>+</sup> Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation Open
Background— Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical challenge. Mechanism-based approaches to AF therapy are sought to increase effectiveness and to provide individualized patient care. K 2P 3.1 (TASK-…