Birgit Edel
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View article: Loop-mediated isothermal amplification as a diagnostic tool for rapid identification of enteric bacterial pathogens from stool samples
Loop-mediated isothermal amplification as a diagnostic tool for rapid identification of enteric bacterial pathogens from stool samples Open
Molecular assays, which are commonly based on multiplex PCR techniques, are increasingly being used to diagnose bacterial gastroenteritis due to faster results and more straightforward workflows compared to conventional culture. Many cultu…
View article: Evaluation of the Eazyplex® Candida ID LAMP Assay for the Rapid Diagnosis of Positive Blood Cultures
Evaluation of the Eazyplex® Candida ID LAMP Assay for the Rapid Diagnosis of Positive Blood Cultures Open
Rapid molecular assays can be used to identify Candida pathogens directly from positive blood cultures (BCs) in a timely manner compared to standard methods using subcultures. In this study, the eazyplex® Candida ID assay, which is based o…
View article: Experience with PCR Testing for Enteric Bacteria and Viruses of Emergency Department Patients with Acute Gastroenteritis: Are There Implications for the Early Treatment of Clostridioides difficile Infection?
Experience with PCR Testing for Enteric Bacteria and Viruses of Emergency Department Patients with Acute Gastroenteritis: Are There Implications for the Early Treatment of Clostridioides difficile Infection? Open
Early identification of acute gastroenteritis (AGE) pathogens via PCR may improve the management of patients presenting to the emergency department (ED). In this study, we evaluated the implementation of a testing algorithm for ED patients…
View article: Competitive inhibition and mutualistic growth in co-infections: deciphering <i>Staphylococcus aureus–Acinetobacter baumannii</i> interaction dynamics
Competitive inhibition and mutualistic growth in co-infections: deciphering <i>Staphylococcus aureus–Acinetobacter baumannii</i> interaction dynamics Open
Staphylococcus aureus (Sa) and Acinetobacter baumannii (Ab) are frequently co-isolated from polymicrobial infections that are severe and refractory to therapy. Here, we apply a combination of wet-lab experiments and in silico modeling to u…
View article: SARS-CoV-2 Testing of Emergency Department Patients Using cobas® Liat® and eazyplex® Rapid Molecular Assays
SARS-CoV-2 Testing of Emergency Department Patients Using cobas® Liat® and eazyplex® Rapid Molecular Assays Open
Rapid testing for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) of patients presenting to emergency departments (EDs) facilitates the decision for isolation on admission to hospital wards. Differences in the sensitivity of m…
View article: Screening of Klebsiella pneumoniae Isolates for Carbapenemase and Hypervirulence-Associated Genes by Combining the Eazyplex® Superbug CRE and hvKp Assays
Screening of Klebsiella pneumoniae Isolates for Carbapenemase and Hypervirulence-Associated Genes by Combining the Eazyplex® Superbug CRE and hvKp Assays Open
The acquisition of hypervirulence-associated genes by carbapenemase-producing Klebsiella pneumoniae is being increasingly observed, and easy-to-use diagnostic tests are needed for the surveillance of the hypervirulent K. pneumoniae (hvKp).…
View article: Development of a rapid diagnostic test based on loop-mediated isothermal amplification to identify the most frequent non-typhoidal Salmonella serovars from culture
Development of a rapid diagnostic test based on loop-mediated isothermal amplification to identify the most frequent non-typhoidal Salmonella serovars from culture Open
Identification of Salmonella serovars is performed by conventional seroagglutination or sequencing. These methods are labor-intensive and require technical experience. An easy-to-perform assay allowing the timely identification of the most…
View article: A Rare Case of Periprosthetic Streptobacillosis - Rapid Identification via Nanopore Sequencing After Inconclusive VITEK MS Results
A Rare Case of Periprosthetic Streptobacillosis - Rapid Identification via Nanopore Sequencing After Inconclusive VITEK MS Results Open
Background Streptobacillus moniliformis is the main cause of human streptobacillosis, also known as rat-bite or Haverhill fever. Generally transferred by bites or scratches of rats and other rodents or by rat-excrement polluted water, symp…
View article: A Rare Case of Periprosthetic Streptobacillosis - Rapid Identification via Nanopore Sequencing after Inconclusive VITEK MS Results
A Rare Case of Periprosthetic Streptobacillosis - Rapid Identification via Nanopore Sequencing after Inconclusive VITEK MS Results Open
Streptobacillus moniliformis is the main cause of human streptobacillosis, also known as rat-bite or Haverhill fever. A correct diagnosis might be delayed due to scarcity, non-specific symptoms, and difficulties in cultivating this fastidi…
View article: Influence of the Incubator as Direct Patient Environment on Bacterial Colonization of Neonates
Influence of the Incubator as Direct Patient Environment on Bacterial Colonization of Neonates Open
Background: Preventing healthcare-associated infections (HAI) in neonatal intensive care units is a challenge of highest priority. For further insight into the incubator as direct patient environment and potential source for contamination,…
View article: Do closed waste containers lead to less air contamination than opened? A clinical case study at Jena University Hospital, Germany
Do closed waste containers lead to less air contamination than opened? A clinical case study at Jena University Hospital, Germany Open
Nosocomial infections are a growing challenge at hospitals. This clinical study aimed to investigate the influence of waste container construction ((open (O), closed (C), and hands-free opening (HF)) on microbial air contamination in a hos…
View article: Performance of the RT-LAMP-based eazyplex® SARS-CoV-2 as a novel rapid diagnostic test
Performance of the RT-LAMP-based eazyplex® SARS-CoV-2 as a novel rapid diagnostic test Open
The eazyplex® SARS-CoV-2 is a rapid assay that accurately identifies samples with high viral loads. It may be useful for near-patient testing outside of a molecular diagnostic laboratory.
View article: A Nosocomial Foodborne Outbreak of a VIM Carbapenemase-Expressing Citrobacter freundii
A Nosocomial Foodborne Outbreak of a VIM Carbapenemase-Expressing Citrobacter freundii Open
An explosive increase in carbapenemase-expressing Enterobacteriaceae contamination may have been caused by a foodborne source, and presliced vegetables should be taken into account as a putative pathogen repository. These findings underlin…
View article: Acute diarrhoea due to a Shiga toxin 2e-producing Escherichia coli O8 : H19
Acute diarrhoea due to a Shiga toxin 2e-producing Escherichia coli O8 : H19 Open
Introduction. Identification of non-O157 Shiga-toxin-producing Escherichia coli (STEC) infections may be underestimated in microbiological diagnosis. Case presentation. A 58-year-old woman developed diarrhoea with watery and subsequently m…
View article: Campylobacter jejuni ssp. jejuni bacteraemia in a patient with BCR-ABL-positive chronic myelogenous leukaemia in remission on dasatinib therapy
Campylobacter jejuni ssp. jejuni bacteraemia in a patient with BCR-ABL-positive chronic myelogenous leukaemia in remission on dasatinib therapy Open
Introduction: We report an unusual case of C ampylobacter jejuni bacteraemia in a patient with Philadelphia chromosome-positive, BCR-ABL-positive chronic myelogenous leukaemia in complete cytogenetic and major molecular remission after das…