Birgit Kalb
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View article: Pre‐chewing for weaning: A traditional method for allergy prevention? Rationale, study design, and methods of the open‐label trial—Solids‐by‐Kiss
Pre‐chewing for weaning: A traditional method for allergy prevention? Rationale, study design, and methods of the open‐label trial—Solids‐by‐Kiss Open
Background The increase of allergies is attributed to a multi‐factorial pathogenesis. Multi‐gene traits, as well as different environmental factors, are regarded as responsible for shaping the development of atopic entities. The microbiome…
View article: Trajectories of allergic diseases in children: Destination unknown?
Trajectories of allergic diseases in children: Destination unknown? Open
The trajectories of allergic diseases represent one of the most currently debated topics both when referred to childhood and likewise adulthood. Data from cohorts show their heterogeneity as well as the key role of genetic and environmenta…
View article: Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial Open
Background Children with sensitization against foods have to be orally food-challenged before eating these foods for the first time. However, the waiting time for an oral food challenge (OFC) in Germany is about 3–6 months. In contrast, th…
View article: Infants and toddlers with sensitization to peanut are often co-sensitized to tree nuts
Infants and toddlers with sensitization to peanut are often co-sensitized to tree nuts Open
Background Due to changes in dietary habits tree nuts (TN) are consumed in many households and TN allergy appears to be increasing. One risk factor seems to be allergies to other food such as peanuts. The aim of our study was to investigat…
View article: An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium
An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium Open
Background Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an…
View article: Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy
Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy Open
Using the gold standard for food allergy diagnosis, this study demonstrates that FLG LOF mutations confer a risk of any food allergy independent of eczema. These mutations predispose to the persistence of HE and CM allergy and should be co…
View article: Follow-up of hen’s egg allergic children: investigation of factors that influence the reevaluation of tolerance development
Follow-up of hen’s egg allergic children: investigation of factors that influence the reevaluation of tolerance development Open
Background: In order to determine tolerance development in hen’s egg (HE) allergic children, international guidelines recommend an oral food challenge after 6-24 months. This study aimed to assess whether parents follow this advice and fac…
View article: Maternal Filaggrin Mutations Increase the Risk of Atopic Dermatitis in Children: An Effect Independent of Mutation Inheritance
Maternal Filaggrin Mutations Increase the Risk of Atopic Dermatitis in Children: An Effect Independent of Mutation Inheritance Open
Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects refl…