Birgit Luef
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Supp. Fig. Legends from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Supplementary Fig. S1 Epigenetic regulation of SOCS3 in cell lines. A, SOCS3 mRNA was measured in AR positive prostate cancer cell lines after treatement with 10 mM 5-Aza-2'deoxycytidine for 72 hours. B, publicly available Bisulfite-Seq. d…
Data from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
The proinflammatory cytokine IL6 is associated with bad prognosis in prostate cancer and implicated in progression to castration resistance. Suppressor of cytokine signaling 3 (SOCS3) is an IL6-induced negative feedback regulator of the IL…
Supp. Fig. 1 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Epigenetic regulation of SOCS3 in cell lines. A, SOCS3 mRNA was measured in AR positive prostate cancer cell lines after treatement with 10 mM 5-Aza-2'deoxycytidine for 72 hours. B, publicly available Bisulfite-Seq. data for the SOCS3 CpG …
Supp. Fig. 1 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Epigenetic regulation of SOCS3 in cell lines. A, SOCS3 mRNA was measured in AR positive prostate cancer cell lines after treatement with 10 mM 5-Aza-2'deoxycytidine for 72 hours. B, publicly available Bisulfite-Seq. data for the SOCS3 CpG …
Supp. Fig. 4 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
AR binding to DNA occurs in close proximity of several important components of the IL6 pathway. Publicly available ChIP-Seq data sets were analyzed to visualize AR binding sites, displayed as black rectangles. A, no AR binding sites could …
Supp. Fig. 2 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
AR positive cell lines do not express IL6 mRNA. IL6 mRNA expression was measured by qPCR during cultivation under normal growth conditions.
Supp. Fig. 2 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
AR positive cell lines do not express IL6 mRNA. IL6 mRNA expression was measured by qPCR during cultivation under normal growth conditions.
Supp. Fig. 5 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
SOCS3 is not regulated on post-transcriptional level by R1881. A luciferase reporter vector containing the coding sequence (CDS) and the 3'UTR of SOCS3 in the untranslated region after the luciferase stop codon was transfected into LNCaP c…
Supp. Fig. 3 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Knock-down and overexpression efficiency of SOCS3 in LNCaP. SOCS3 expression in LNCaP was modulated by stable over-expression and knock-down with lentiviral vectors and the effect on SOCS3 mRNA was determined by qPCR after 72 hours of reat…
Supp. Fig. 6 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Knock-down and overexpression of SOCS3 is sustained after 3 weeks of combined IL6 and Enzalutamide treatment. SOCS3 expression in LNCaP was modulated by lentiviral over-expression and knock-down with a pool of 3 individual shRNAs targeting…
Supp. Fig. 5 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
SOCS3 is not regulated on post-transcriptional level by R1881. A luciferase reporter vector containing the coding sequence (CDS) and the 3'UTR of SOCS3 in the untranslated region after the luciferase stop codon was transfected into LNCaP c…
Data from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
The proinflammatory cytokine IL6 is associated with bad prognosis in prostate cancer and implicated in progression to castration resistance. Suppressor of cytokine signaling 3 (SOCS3) is an IL6-induced negative feedback regulator of the IL…
Supp. Fig. 6 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Knock-down and overexpression of SOCS3 is sustained after 3 weeks of combined IL6 and Enzalutamide treatment. SOCS3 expression in LNCaP was modulated by lentiviral over-expression and knock-down with a pool of 3 individual shRNAs targeting…
Supp. Fig. Legends from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Supplementary Fig. S1 Epigenetic regulation of SOCS3 in cell lines. A, SOCS3 mRNA was measured in AR positive prostate cancer cell lines after treatement with 10 mM 5-Aza-2'deoxycytidine for 72 hours. B, publicly available Bisulfite-Seq. d…
Supp. Fig. 4 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
AR binding to DNA occurs in close proximity of several important components of the IL6 pathway. Publicly available ChIP-Seq data sets were analyzed to visualize AR binding sites, displayed as black rectangles. A, no AR binding sites could …
Supp. Fig. 3 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells Open
Knock-down and overexpression efficiency of SOCS3 in LNCaP. SOCS3 expression in LNCaP was modulated by stable over-expression and knock-down with lentiviral vectors and the effect on SOCS3 mRNA was determined by qPCR after 72 hours of reat…
View article: Commensal and Opportunistic Bacteria Present in the Microbiota in Atlantic Cod (Gadus morhua) Larvae Differentially Alter the Hosts’ Innate Immune Responses
Commensal and Opportunistic Bacteria Present in the Microbiota in Atlantic Cod (Gadus morhua) Larvae Differentially Alter the Hosts’ Innate Immune Responses Open
The roles of host-associated bacteria have gained attention lately, and we now recognise that the microbiota is essential in processes such as digestion, development of the immune system and gut function. In this study, Atlantic cod larvae…
Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112 Open
The histone acetyltransferase (HAT) enzymes p300 and CBP are closely related paralogs that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. p300/CBP is a multidomain protein and pos…
The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1 Open
Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen receptor (AR)-interacting proteins should be investigated. In this study we aimed to address whether the AR coactivator nuclear receptor coactivator 1 (NC…