Explanipedia

Bladder cancer detection in urine by novel methylation markers Open

Irene Beijert, Birgit M. M. Wever, Anouk E. Hentschel, Yara van den Burgt, Paul C. Kauer , et al. · 2024

Molecular analysis for ovarian cancer detection in patient-friendly samples Open

Birgit M. M. Wever, Mirte Schaafsma, Maaike Bleeker, Yara van den Burgt, Rianne van den Helder , et al. · 2024

Background High ovarian cancer mortality rates motivate the development of effective and patient-friendly diagnostics. Here, we explored the potential of molecular testing in patient-friendly samples for ovarian cancer detection. Methods H…

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities Open

Birgit M. M. Wever, Renske D.M. Steenbergen · 2024

High cancer mortality rates and the rising cancer burden worldwide drive the development of innovative methods in order to advance cancer diagnostics. Urine contains a viable source of tumor material and allows for self‐collection from hom…

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing Open

Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E. Hentschel, Birgit M. M. Wever , et al. · 2023

Molecular analysis for ovarian cancer detection in patient-friendly samples Open

Birgit M. M. Wever, Mirte Schaafsma, Maaike C.G. Bleeker, Yara van den Burgt, Rianne van den Helder , et al. · 2023

Background High ovarian cancer mortality rates motivate the development of effective and patient-friendly diagnostics. Here, we explored the potential of molecular testing in patient-friendly samples for ovarian cancer detection. Patients …

<span>DNA</span> methylation testing for endometrial cancer detection in urine, cervicovaginal self‐samples and cervical scrapes Open

Birgit M. M. Wever, Rianne van den Helder, Annina P. van Splunter, Mignon D J M van Gent, Jenneke C. Kasius , et al. · 2023

Endometrial cancer incidence is rising and current diagnostics often require invasive biopsy procedures. DNA methylation marker analysis of minimally‐ and non‐invasive sample types could provide an easy‐to‐apply and patient‐friendly altern…

2022-RA-580-ESGO Endometrial cancer detection by DNA methylation testing in cervical scrapes, cervicovaginal self-samples and urine Open

Birgit M. M. Wever, Rianne van den Helder, Annina P. van Splunter, Nienke E. van Trommel, Renske D.M. Steenbergen , et al. · 2022

Detection of non-metastatic non-small-cell lung cancer in urine by methylation-specific PCR analysis: A feasibility study Open

Birgit M. M. Wever, Sander Bach, Marco Tibbesma, Timo J. ter Braak, D. Wajon , et al. · 2022

Urine CDO1 and SOX17 showed increased methylation levels in NSCLC patients as compared to sex- and age-matched controls. This demonstrates that urine ctDNA methylation analysis may provide an interesting non-invasive means to detect non-me…

Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients Open

Sander Bach, Birgit M. M. Wever, Mark A. van de Wiel, Joris D. Veltman, Sayed M.S. Hashemi , et al. · 2022

High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research. This study aimed to investigate the circadian variation of urinary cell-free D…

Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients Open

Sander Bach, Birgit M. M. Wever, Mark A. van de Wiel, Joris D. Veltman, Sayed M.S. Hashemi , et al. · 2021

High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research. This study aimed to investigate the circadian variation of urinary cell-free D…

Non-invasive detection of endometrial cancer by DNA methylation analysis in urine Open

Rianne van den Helder, Birgit M. M. Wever, Nienke E. van Trommel, Annina P. van Splunter, Constantijne H. Mom , et al. · 2020

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