Explanipedia

Shifts in Cutaneous Melanocytic Tumor Diagnostic Terminology: Melanocytoma, MPATH‐Dx V2.0 and the WHO Skin5 Open

Lyn M. Duncan, David E. Elder, Michael W. Piepkorn, Stevan R. Knezevich, Willeke A.M. Blokx , et al. · 2025

In this Special Issue of the Journal of Cutaneous Pathology in memory of Dr. Martin C. Mihm, Jr, we highlight his many contributions over more than 50 years to the catalog of specific melanocytic tumor terminology. Dr. Mihm was an active p…

Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets Open

Pranali Shah, G. Romar, Artür Manukyan, Wei-Che Ko, Pei‐Chen Hsieh , et al. · 2024

Delayed-type drug hypersensitivity reactions are major causes of morbidity and mortality. The origin, phenotype, and function of pathogenic T cells across the spectrum of severity require investigation. We leveraged recent technical advanc…

Addendum: Resolvins suppress tumor growth and enhance cancer therapy Open

Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang , et al. · 2024

A case of neonatal sweet syndrome associated with mevalonate kinase deficiency Open

Margaret Irwin, Veeraya K. Tanawattanacharoen, Amy Turner, Mary Beth F. Son, Rebecca C. Hale , et al. · 2023

Background Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an immunologic syndrome characterized by widespread neutrophilic infiltration. Histiocytoid Sweet syndrome (H-SS) is a histopathologic variant of SS. W…

Treatment of Genital Crohn's Disease With Upadacitinib in a Male Child: A Case Report. Open

Athos Bousvaros, Birgitta Schmidt, Michael P. Kurtz · 2023

Revision of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis Classification Schema for Melanocytic Lesions Open

Raymond L. Barnhill, David E. Elder, Michael W. Piepkorn, Stevan R. Knezevich, Lisa M. Reisch , et al. · 2023

Importance A standardized pathology classification system for melanocytic lesions is needed to aid both pathologists and clinicians in cataloging currently existing diverse terminologies and in the diagnosis and treatment of patients. The …

Pediatric Lichen Myxedematosus: A Diagnostic and Management Challenge Open

Kelly K. Barry, Diana B. Reusch, Birgitta Schmidt, Elena B. Hawryluk · 2022

Localized lichen myxedematosus (LM) is a rare, idiopathic mucinosis characterized by dermal mucin deposition and variable fibroblast proliferation. Nodular lichen myxedematosus, a clinicopathologic subtype of localized LM, is exceedingly r…

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα) Open

Wayne Bainter, Vassilios Lougaris, Jacqueline G. Wallace, Yousef R. Badran, Rodrigo Hoyos‐Bachiloglu , et al. · 2021

A mutation in human IKKα compromises noncanonical NF-κB signaling resulting in primary immunodeficiency associated with autoimmunity.

Management of Residual Spitz Nevus in Surgical Specimens following Biopsy and Excision Open

Usha E. A. Beijnen, Landis R. Walsh, Laura C. Nuzzi, Birgitta Schmidt, Brian I. Labow , et al. · 2020

Background: Proper management of Spitz nevi continues to be debated, with treatment ranging from observation to surgery. To better characterize the outcome of surgical procedures performed for incomplete initial excision or biopsy, we soug…

Paediatric spitzoid proliferations Open

Diana W. Bartenstein, Jonathan Fisher, Catherine Stamoulis, Christopher B. Weldon, Jun-xin Huang , et al. · 2019

Spitz naevi are a type of mole (brown skin lump). They are smooth, rounded, pink, red or brown. They contain pigment cells known as spitzoid proliferations. Some spitz naevi look quite worrying, growing rapidly and dark brown in colour, an…

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases Open

Dipak Panigrahy, Allison Gartung, Jun Yang, Haixia Yang, Molly M. Gilligan , et al. · 2019

Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an inflammatory/immunosuppressive injury response that promotes dormancy escape and tumor recurrence. We hypothesized that these events could be altered by earl…

Risk Factors and Outcomes of Nonmelanoma Skin Cancer in Children and Young Adults Open

Jennifer T. Huang, Carrie C. Coughlin, Elena B. Hawryluk, Kristen P. Hook, Stephen R. Humphrey , et al. · 2019

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor Open

Allison Gartung, Jun Yang, Vikas P. Sukhatme, Diane R. Bielenberg, Djanira Fernandes , et al. · 2019

Significance Our study demonstrates that ovarian tumor cell debris generated by front-line chemotherapy promotes tumor growth by stimulating the release of proinflammatory cytokines and lipid mediators in the tumor microenvironment. Target…

Clinical features and outcomes of spitzoid proliferations in children and adolescents Open

Diana W. Bartenstein, Jonathan Fisher, Catherine Stamoulis, Christopher B. Weldon, Jennifer T. Huang , et al. · 2018

Spitz tumours have strikingly benign outcomes in the paediatric population, although this study is limited by the low number of melanomas and restriction to a single paediatric institution. Aggressive management recommendations should be r…

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice Open

Haixia Yang, Weicang Wang, Kymberleigh A. Romano, Min Gu, Katherine Z. Sanidad , et al. · 2018

The commonly used antimicrobial compound triclosan increases colonic inflammation and colon cancer in mice.

Resolvins suppress tumor growth and enhance cancer therapy Open

Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang , et al. · 2017

Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this stu…

Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1 Open

Craig D. Platt, Ari J. Fried, Rodrigo Hoyos‐Bachiloglu, G. Naheed Usmani, Birgitta Schmidt , et al. · 2017

Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site Open

Craig D. Platt, Michel J. Massaad, Brittney Cangemi, Birgitta Schmidt, Hasan Al‐Dhekri , et al. · 2016

Evaluation of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) classification scheme for diagnosis of cutaneous melanocytic neoplasms: Results from the International Melanoma Pathology Study Group Open

Jason P. Lott, Joann G. Elmore, Ge Zhao, Stevan R. Knezevich, Frederick A. Spencer , et al. · 2016

Nodular Foot Myxedema Masquerading as Lymphedema Open

Javier Couto, Birgitta Schmidt, Arin K. Greene · 2015

Lymphedema results from abnormal development or injury to the lymphatic system. One-fourth of patients with lower extremity enlargement are erroneously labeled with "lymphedema." We describe a patient with hypothyroidism who developed soft…

Birgitta Schmidt YOU? Author Swipe