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View article: Enhancer Hijacking of the IGH Locus as a Novel Genetic Mechanism of an Inborn Error of Immunity Leading to Invasive <i>Streptococcus pneumoniae</i> Infection due to Antibody Deficiency
Enhancer Hijacking of the IGH Locus as a Novel Genetic Mechanism of an Inborn Error of Immunity Leading to Invasive <i>Streptococcus pneumoniae</i> Infection due to Antibody Deficiency Open
We investigated the genetic cause of disease in five affected individuals from two unrelated families with an autosomal dominant pattern of invasive Streptococcus pneumoniae infection associated with a clinical phenotype of specific antibo…
View article: Understanding Asymptomatic Malaria: The Utility of Wild-Derived Mouse Diversity
Understanding Asymptomatic Malaria: The Utility of Wild-Derived Mouse Diversity Open
With over 200 million clinical cases per year leading to over 600,000 deaths, malaria is still a significant global health problem. Up to 80% of individuals in some malaria-endemic areas can have asymptomatic carriage of Plasmodium infecti…
View article: SARS-CoV-2 Omicron boosting induces de novo B cell response in humans
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans Open
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses of these vaccines and the development of new variant-derived ones 1–4 . S…
View article: The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function
The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function Open
Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of in…