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View article: Beyond the binary: integrating “real-world evidence” with randomized trials in contemporary health care
Beyond the binary: integrating “real-world evidence” with randomized trials in contemporary health care Open
Key findings We suggest developing an integrated framework combining randomized controlled trials (RCTs) and real-world evidence (RWE), emphasizing their complementary strengths in health-care research. Currently, this integration is often…
View article: Plain language summary: how long do patients with metastatic castration-resistant prostate cancer (mCRPC) live when taking abiraterone or enzalutamide in the real world?
Plain language summary: how long do patients with metastatic castration-resistant prostate cancer (mCRPC) live when taking abiraterone or enzalutamide in the real world? Open
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View article: Plain language summary: does race or income status affect the cancer treatments that patients with metastatic castration-sensitive prostate cancer (mCSPC) receive in the United States?
Plain language summary: does race or income status affect the cancer treatments that patients with metastatic castration-sensitive prostate cancer (mCSPC) receive in the United States? Open
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View article: Physician Reasons for or Against Treatment Intensification in Patients With Metastatic Prostate Cancer
Physician Reasons for or Against Treatment Intensification in Patients With Metastatic Prostate Cancer Open
Importance Clarifying the underutilization of treatment intensification (TI) for metastatic castration-sensitive prostate cancer (mCSPC) may improve implementation of evidence-based medicine and survival outcomes. Objective To investigate …
View article: Using a data-driven approach to define post-COVID conditions in US electronic health record data
Using a data-driven approach to define post-COVID conditions in US electronic health record data Open
Objective To create a data-driven definition of post-COVID conditions (PCC) by directly measure changes in symptomatology before and after a first COVID episode. Materials and methods Retrospective cohort study using Optum® de-identified E…
View article: Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer
Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer Open
Background Previous studies have shown that Black men receive worse prostate cancer care than White men. This has not been explored in metastatic castration-sensitive prostate cancer (mCSPC) in the current treatment era. Methods We evaluat…
View article: Subphenotypes of self-reported symptoms and outcomes in long COVID: a prospective cohort study with latent class analysis
Subphenotypes of self-reported symptoms and outcomes in long COVID: a prospective cohort study with latent class analysis Open
Objective To characterise subphenotypes of self-reported symptoms and outcomes (SRSOs) in postacute sequelae of COVID-19 (PASC). Design Prospective, observational cohort study of subjects with PASC. Setting Academic tertiary centre from fi…
View article: <scp>NAFLD</scp> and <scp>NASH</scp> are obesity‐independent risk factors in <scp>COVID</scp>‐19: Matched real‐world results from the large <scp>PINC AI</scp>™ Healthcare Database
<span>NAFLD</span> and <span>NASH</span> are obesity‐independent risk factors in <span>COVID</span>‐19: Matched real‐world results from the large <span>PINC AI</span>™ Healthcare Database Open
Background & Aims Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) are potential risk factors for severe pneumonia and other infections. Available data on the role of NAFLD/NASH in worsening outcomes for C…
View article: A New Projection Pursuit Index for Big Data
A New Projection Pursuit Index for Big Data Open
Visualization of extremely large datasets in static or dynamic form is a huge challenge because most traditional methods cannot deal with big data problems. A new visualization method for big data is proposed based on Projection Pursuit, G…
View article: Effectiveness of Crizotinib in Patients with <i>ROS1</i> -Positive Non-Small-Cell Lung Cancer: Real-World Evidence in Japan
Effectiveness of Crizotinib in Patients with <i>ROS1</i> -Positive Non-Small-Cell Lung Cancer: Real-World Evidence in Japan Open
Aim: Crizotinib, approved in Japan (2017) for ROS1-positive NSCLC, has limited real-world data. Materials & methods: Crizotinib monotherapy real-world effectiveness and treatment status were analyzed from claims data (June 2017-March 2021;…
View article: Subphenotypes of Self-Reported Symptoms and Outcomes in Long COVID: a prospective cohort study with latent class analysis
Subphenotypes of Self-Reported Symptoms and Outcomes in Long COVID: a prospective cohort study with latent class analysis Open
Objective To characterize subphenotypes of self-reported symptoms and outcomes(SRSOs) in Post-acute sequelae of COVID-19(PASC). Design Prospective, observational cohort study of PASC subjects. Setting Academic tertiary center from five cli…
View article: Quantifying The Burden of Persistent Musculoskeletal Pain in Employees at Rolls-Royce in The United Kingdom
Quantifying The Burden of Persistent Musculoskeletal Pain in Employees at Rolls-Royce in The United Kingdom Open
Objective We aimed to investigate the burden of persistent musculoskeletal (MSK) pain in Rolls-Royce UK employees. Methods Employees with ( n = 298) and without ( n = 329) persistent MSK pain completed a cross-sectional survey. Weighted re…
View article: Real‐world therapeutic effectiveness of lorlatinib after alectinib in Japanese patients with <i>ALK</i>‐positive non‐small‐cell lung cancer
Real‐world therapeutic effectiveness of lorlatinib after alectinib in Japanese patients with <i>ALK</i>‐positive non‐small‐cell lung cancer Open
Alectinib, an anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), is the recommended first‐line treatment for ALK ‐positive non‐small‐cell lung cancer (NSCLC) in Japan. Lorlatinib was approved as a subsequent therapeutic opti…
View article: Effectiveness and Safety of Apixaban vs Warfarin in Patients with Venous Thromboembolism with Risk Factors for Bleeding or for Recurrences
Effectiveness and Safety of Apixaban vs Warfarin in Patients with Venous Thromboembolism with Risk Factors for Bleeding or for Recurrences Open
Patients with prescription fills for apixaban had lower risk of recurrent VTE, MB, and CRNM bleeding compared with warfarin patients. Treatment effects of apixaban vs warfarin were generally consistent across subgroups of patients at incre…
View article: Real‐world study of next‐generation sequencing diagnostic biomarker testing for patients with lung cancer in Japan
Real‐world study of next‐generation sequencing diagnostic biomarker testing for patients with lung cancer in Japan Open
Our previous real‐world studies raised concerns that sequential biomarker testing may lead to increased time to treatment when compared with simultaneous single biomarker testing. The Oncomine Dx target test (ODxTT), a next‐generation sequ…
View article: Warfarin Time in Therapeutic INR Range and Direct Oral Anticoagulant Adherence for Venous Thromboembolism Across the Spectrum of Weight and Body Mass Index: Findings from Veterans Health Administration
Warfarin Time in Therapeutic INR Range and Direct Oral Anticoagulant Adherence for Venous Thromboembolism Across the Spectrum of Weight and Body Mass Index: Findings from Veterans Health Administration Open
The evidence of direct oral anticoagulants (DOACs) usage for venous thromboembolism (VTE) in patients at extremes of body weight or mass index is limited. In such situations, warfarin may be more frequently used. We investigated warfarin t…
View article: Effectiveness and Safety of Direct Oral Anticoagulants Among Patients with Non-valvular Atrial Fibrillation and Multimorbidity
Effectiveness and Safety of Direct Oral Anticoagulants Among Patients with Non-valvular Atrial Fibrillation and Multimorbidity Open
Patients with NVAF and ≥ 6 comorbid conditions had significantly different risks for stroke/SE and MB when comparing DOACs to DOACs, and different healthcare expenses. This study's results may be useful for evaluating the risk-benefit rati…
View article: Effectiveness and safety of apixaban vs warfarin among venous thromboembolism patients at high-risk of bleeding
Effectiveness and safety of apixaban vs warfarin among venous thromboembolism patients at high-risk of bleeding Open
This study evaluated effectiveness and safety of apixaban versus warfarin among venous thromboembolism patients at high-risk of bleeding (defined as having at least one of the following bleeding risk factors: ≥75 years; used antiplatelet, …
View article: Risk Factors Associated With Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients With Osteoarthritis
Risk Factors Associated With Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients With Osteoarthritis Open
Background: While prior research has shown that patients with osteoarthritis (OA) who are prescribed opioids have higher rates of falls and fractures following drug initiation, there is a limited body of work establishing a comprehensive m…
View article: Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis
Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis Open
Background While prior research has shown that patients with osteoarthritis (OA) who are prescribed opioids have higher rates of falls and fractures following drug initiation, there is a limited body of work establishing a comprehensive mo…