Birte Ohm
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View article: CD26 as a potential therapeutic target for lung adenocarcinoma
CD26 as a potential therapeutic target for lung adenocarcinoma Open
Introduction CD26/dipeptidyl peptidase 4 (CD26, DPP4) is a transmembrane exopeptidase that modulates tumorigenesis in different malignancies. We demonstrated before that CD26 inhibition decreases lung tumor growth in experimental models. H…
View article: Detection of malignant lung tumors using stimulated Raman histology and convolutional neural networks
Detection of malignant lung tumors using stimulated Raman histology and convolutional neural networks Open
The results of this study demonstrate the ability of CNNs to identify malignant tumors of the lung on SRS and SRH images. A distinction between different World Health Organization (WHO) subtypes of primary lung cancer and between primary l…
View article: Influence of preprocessing of stimulated Raman scattering images on the performance of deep neural networks for detecting cancer tissue
Influence of preprocessing of stimulated Raman scattering images on the performance of deep neural networks for detecting cancer tissue Open
This study shows that preprocessing of pixel values of stimulated Raman scattering images can have a great impact on the performance and the stability of deep learning algorithms when applied for classification of cancer tissue.
View article: Chimerism and immunological tolerance in solid organ transplantation
Chimerism and immunological tolerance in solid organ transplantation Open
In solid organ transplantation, chimerism inevitably occurs via the coexistence of donor-derived cells from the graft and host cells throughout the recipient. However, long-term immunosuppressive treatment is needed to suppress host immune…
View article: Repeated Single-lung Transplantation After Previous Contralateral Pneumonectomy—A Unique Challenge
Repeated Single-lung Transplantation After Previous Contralateral Pneumonectomy—A Unique Challenge Open
Unilateral lung transplantation after previous contralateral pneumonectomy is a rare clinical situation and is associated with an increased risk of perioperative morbidity and mortality. Such patients, reliant on their single transplant lu…
View article: Targeting CD26/DPP4 in organ fibrosis
Targeting CD26/DPP4 in organ fibrosis Open
CD26/DPP4 is an exopeptidase that is expressed on the cell surface of many organs but is also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of chronic fib…
View article: Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies
Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies Open
The transplantation model provides the opportunity to assess the relevance of a molecule of interest for tumor cell extravasation by using a respective genetically modified donor animal. Here, we present a protocol for orthotopic single-lu…
View article: Balancing the Risk of Adverse Events against the Efficacy of Immunotherapy in Advanced Thymic Epithelial Tumors
Balancing the Risk of Adverse Events against the Efficacy of Immunotherapy in Advanced Thymic Epithelial Tumors Open
Thymic epithelial tumors (TETs) are rare thoracic malignancies with a favorable prognosis when complete surgical resection can be achieved. Therapeutic options for advanced, irresectable, or recurrent disease are limited and currently, a t…
View article: Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis Open
Cluster of differentiation 26 (CD26)/dipeptidyl peptidase 4 (DPP4) is an exopeptidase that is expressed as a transmembrane protein in many organs but also present in a circulating soluble form. Beyond its enzymatic and costimulatory activi…
View article: B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications
B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications Open
Allograft rejection remains the major hurdle in lung transplantation despite modern immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly recognized as modulators of alloimmunity and initiators of a don…
View article: C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection Open
Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that s…