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View article: Table s8 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s8 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Antibody list for FACS
View article: Data from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Data from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic, stiff tumor microenvironment in which tumor-associated macrophages (TAM) drive extracellular matrix remodeling, progression, and immune evasion. The contribution of me…
View article: Supplementary Figures S1-S26 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Supplementary Figures S1-S26 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Supplementary Fig. S1 shows representative images of human adjacent normal and PDAC tissues post-surgery, alongside representative images of Masson's trichrome staining for human adjacent normal and PDAC tissues. Supplementary Fig. S2 depi…
View article: Table s4 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s4 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
The GO enrichment analysis results of monocyte/macrophage cell subtype markers
View article: Table s1 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s1 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
The patient information of ST samples
View article: Table s2 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s2 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Gene markers, DEGs and GSEA analysis
View article: Table s3 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s3 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
GO enrichment analysis of genes identified through CUT&Tag data
View article: Table s7 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s7 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Antibody list for mIHC
View article: Table s5 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s5 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Primers used in the study.
View article: Table s6 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer
Table s6 from The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer Open
Antibody list for IHC
View article: Search for $e^+e^-\to K_S^0 K_S^0 h_c$
Search for $e^+e^-\to K_S^0 K_S^0 h_c$ Open
Using $e^+e^-$ collision data at 13 center-of-mass energies ranging from 4.600 to 4.950 GeV collected with the BESIII detector, we search for the unmeasured $e^+e^-\to K_S^0 K_S^0 h_c$ process . No significant signal is observed, and the u…
View article: miR-124 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma by downregulating STATS
miR-124 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma by downregulating STATS Open
miR-124 inhibits the proliferation, migration and invasion of ESCC cells by downregulating STATS, indicating that miR-124 may serve as a molecular candidate for treating ESCC.
View article: Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE Open
Outer membrane (OM) lipoproteins serve vital roles in Gram-negative bacteria, contributing to their pathogenicity and drug resistance. For these lipoproteins to function, they must be transported from the inner membrane (IM), where they ar…
View article: An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer
An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic, stiff tumor microenvironment (TME), where tumor-associated macrophages (TAMs) drive ECM remodeling, progression, and immune evasion. The contribution of mechanical cue…
View article: Single-cell multiomics reveals endothelial mechanosensitive PIEZO1 coupling IL-33 regulates the development of pulmonary fibrosis
Single-cell multiomics reveals endothelial mechanosensitive PIEZO1 coupling IL-33 regulates the development of pulmonary fibrosis Open
Pulmonary fibrosis (PF) is a lethal lung disease characterized by aberrant lung scarring. Vascular endothelial cells (VECs), which activate fibroblasts through secreting pro-fibrotic molecules, are vital for the PF development. However, th…
View article: Lung regeneration: diverse cell types and the therapeutic potential
Lung regeneration: diverse cell types and the therapeutic potential Open
Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system fa…
View article: Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis
Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis Open
Hepatocellular carcinoma is one of the leading cancers worldwide and is a potential consequence of fibrosis. Therefore, the identification of key cellular and molecular mechanisms involved in liver fibrosis is an important goal for the dev…
View article: Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis
Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis Open
Chronic liver diseases affect over a billion people worldwide and often lead to fibrosis. Nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes, is characterized by liver fibrosis, and its path…
View article: Integrated analyses of single-cell transcriptomics identify metastasis-associated myeloid subpopulations in breast cancer lung metastasis
Integrated analyses of single-cell transcriptomics identify metastasis-associated myeloid subpopulations in breast cancer lung metastasis Open
Lung metastasis of breast cancer is closely associated with patient morbidity and mortality, which correlates with myeloid cells in the lung microenvironment. However, the heterogeneity and specificity of metastasis-associated myeloid cell…
View article: Inflammation induced epigenetic activation of bivalent genes in osteoarthritic cartilage
Inflammation induced epigenetic activation of bivalent genes in osteoarthritic cartilage Open
Osteoarthritis (OA) is the most prevalent joint disorder occurring with articular cartilage degradation, which includes a switch from an articular to a growth-plate chondrocyte phenotype. Epigenetics serves as a new therapeutic target but …
View article: Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS
Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS Open
Vascular leakage and inflammation are pathological hallmarks of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Endothelial cells (ECs) serve as a semipermeable barrier and play a key role in disease progression. It is …
View article: Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling
Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling Open
Despite the robust healing capacity of the liver, regenerative failure underlies numerous hepatic diseases, including the JAG1 haploinsufficient disorder, Alagille syndrome (ALGS). Cholestasis due to intrahepatic duct (IHD) paucity resolve…
View article: Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis
Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis Open
The vasculature occupies a large area of the body, and none of the physiological activities can be carried out without blood vessels. Blood vessels are not just passive conduits and barriers for delivering blood and nutrients. Meanwhile, e…