Biswadev Bishayi
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View article: Fruit Bioactive Compounds as P-Glycoprotein Inhibitors - An In-Silico Study
Fruit Bioactive Compounds as P-Glycoprotein Inhibitors - An In-Silico Study Open
Introduction: P-glycoprotein is a crucial efflux transporter whose overexpression contributes to drug resistance, hindering effective treatment of various diseases. Objective: This study aims to identify the inhibitory bioactive fruit comp…
View article: Concomitant inhibition of TLR4 and NLRP3 inflammasome in macrophages regulates lipopolysaccharide induced inflammation
Concomitant inhibition of TLR4 and NLRP3 inflammasome in macrophages regulates lipopolysaccharide induced inflammation Open
LPS serves as a potent inducer of inflammation leading to Sepsis, primarily through the activation of the TLR4-NF-κB signaling pathway. TLR4 is a target of choice for the development of novel anti-sepsis therapies. Nowadays, NLRP3 has also…
View article: Simultaneous blockade of TLR4 and TNFR1 attenuates TLR2 sensitivity in LPS-stimulated macrophages through TNFR2-mediated pathway
Simultaneous blockade of TLR4 and TNFR1 attenuates TLR2 sensitivity in LPS-stimulated macrophages through TNFR2-mediated pathway Open
Background: Recent studies have found TLR2 to be a significant player in initiating immune responses in the host during bacterial infection. Macrophage polarization is one of the vital factors in the amelioration of sepsis. It is well esta…
View article: TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses Open
Due to the urgent need to create appropriate treatment techniques, which are currently unavailable, LPS-induced sepsis has become a serious concern on a global scale. The primary active component in the pathophysiology of inflammatory dise…
View article: Neutralization of TGF-β in combination with IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in murine lymphocytes
Neutralization of TGF-β in combination with IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in murine lymphocytes Open
Septic arthritis is an inflammatory joint disease caused by S. aureus. Hematogenous entry of the bacteria to the joint space secretespro-inflammatory cytokines TGF-β and IL-6, which alter the Th17/Treg switch. Inhibition of TGF-β and IL-6 …
View article: <i>Catharanthus roseus</i> (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant <i>Staphylococcus aureus</i> by downregulation of PBP2a synthesis
<i>Catharanthus roseus</i> (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant <i>Staphylococcus aureus</i> by downregulation of PBP2a synthesis Open
It is essential to revisit the global biodiversity, search for ethnopharmacologically relevant plants, and unveil their untapped potential to overcome the complications associated while treating infections triggered by multiple antibiotic-…
View article: Multiple antibiotic resistant Staphylococcus aureus induced hepatocellular anomaly: A possible amelioration by Catharanthus roseus (L.) G.Don
Multiple antibiotic resistant Staphylococcus aureus induced hepatocellular anomaly: A possible amelioration by Catharanthus roseus (L.) G.Don Open
In the absence of a viable strategy for treating multiple antibiotic-resistant Staphylococcus aureus (SA)-mediated infections, botanicals are being investigated for their effectiveness and safety. Catharanthus roseus (L.) G.Don (CR), belon…
View article: Prevalence of community-associated Staphylococcus aureus strains among university students
Prevalence of community-associated Staphylococcus aureus strains among university students Open
Colonization of multiple antibiotic resistant Staphylococcus aureus (S. aureus) in nasal cavity is associated with heightened risk of infections. The emergence and spread of multiple antibiotic resistant community-associated (MAR-CA) S. au…
View article: CCR-2 neutralization augments murine fresh BMC activation by <i>Staphylococcus aureus</i> via two distinct mechanisms: at the level of ROS production and cytokine response
CCR-2 neutralization augments murine fresh BMC activation by <i>Staphylococcus aureus</i> via two distinct mechanisms: at the level of ROS production and cytokine response Open
CCR-2 signaling regulates recruitment of monocytes from the bone marrow into the bloodstream and then to sites of infection. We sought to determine whether CCL-2/CCR-2 signaling is involved in the killing of Staphylococcus aureus by murine…
View article: COMBINATION TREATMENTS USING VANCOMYCIN WITH IMMUNOMODULATORS TO MODULATE STAPHYLOCOCCAL ARTHRITIS
COMBINATION TREATMENTS USING VANCOMYCIN WITH IMMUNOMODULATORS TO MODULATE STAPHYLOCOCCAL ARTHRITIS Open
Objective: Staphylococcus aureus is an intensely studied organism to cause septic arthritis. This study aims at using vancomycin to mitigate the bacterial burden in mice infected with pathogenic strain of S. aureus which is combined with t…
View article: Protective effects of methanolic extract of Adhatoda vasica Nees leaf in collagen-induced arthritis by modulation of synovial toll-like receptor-2 expression and release of pro-inflammatory mediators
Protective effects of methanolic extract of Adhatoda vasica Nees leaf in collagen-induced arthritis by modulation of synovial toll-like receptor-2 expression and release of pro-inflammatory mediators Open
RA associated with oxidative stress and chronic inflammation has been a major health problem among the population worldwide. In this study protective effect of methanolic extract of Adhatoda vasica leaf (AVE) was evaluated on Collagen-indu…
View article: In vitro susceptibility of a penicillin-resistant and tolerable isolate of Streptococcus pneumoniae to combination therapy
In vitro susceptibility of a penicillin-resistant and tolerable isolate of Streptococcus pneumoniae to combination therapy Open
Introduction: Preference for combination therapy to treat infection due to multidrug-resistant S. pneumoniae (MDRSP) has not been well elucidated in previous studies. Methodology: In the present study, 19 antibiotics in combinations were t…
View article: EFFECTS OF CIPROFLOXACIN IN COMBINATION WITH EITHER AMINOGUANIDINE OR MECLOFENAMIC ACID IN MODULATING S. AUREUS INDUCED SEPTIC ARTHRITIS IN MICE
EFFECTS OF CIPROFLOXACIN IN COMBINATION WITH EITHER AMINOGUANIDINE OR MECLOFENAMIC ACID IN MODULATING S. AUREUS INDUCED SEPTIC ARTHRITIS IN MICE Open
Objective: Staphylococcus aureus (S. aureus) is a potent causative organism of septic arthritis. In this study, ciprofloxacin was used to nullify the bacterial burden in mice infected with pathogenic strain of S. aureus. Since, endoge…
View article: Killing of Staphylococcus aureus in murine macrophages by chloroquine used alone and in combination with ciprofloxacin or azithromycin
Killing of Staphylococcus aureus in murine macrophages by chloroquine used alone and in combination with ciprofloxacin or azithromycin Open
This study aimed to determine any alteration in the killing of Staphylococcus aureus in murine peritoneal macrophages when chloroquine (CQ) is used alone compared with when it is used in combination with ciprofloxacin (CIP) or azithromycin…
View article: Characterization of Toll-Like Receptor-4 (TLR-4) in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia
Characterization of Toll-Like Receptor-4 (TLR-4) in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia Open
Expression of innate immune receptors varies among organs and species and within different strains among the same species; thus, periodic classification of different pattern recognition receptors in the available strains is necessary to in…