Bita Khalili
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View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common…
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient ( N =668,288). We found 162 genomic loci associated with a comm…
View article: Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine
Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine Open
Gene products can affect the concentrations of small molecules (aka "metabolites"), and conversely, some metabolites can modulate the concentrations of gene transcripts. While many specific instances of this interplay have been revealed, a…
View article: Fission Yeast Polarization: Modeling Cdc42 Oscillations, Symmetry Breaking, and Zones of Activation and Inhibition
Fission Yeast Polarization: Modeling Cdc42 Oscillations, Symmetry Breaking, and Zones of Activation and Inhibition Open
Cells polarize for growth, motion, or mating through regulation of membrane-bound small GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP exchange factors) and inhibitors (GAPs, GTPase activating proteins…
View article: Untargeted metabolome- and transcriptome-wide association study identifies causal genes modulating metabolite concentrations in urine
Untargeted metabolome- and transcriptome-wide association study identifies causal genes modulating metabolite concentrations in urine Open
Summary In this study we investigate the results of a metabolome- and transcriptome-wide association study to identify genes influencing the human metabolome. We used RNAseq data from lymphoblastoid cell lines (LCLs) derived from 555 Cauca…
View article: Automated Analysis of Large-Scale NMR Data Generates Metabolomic Signatures and Links Them to Candidate Metabolites
Automated Analysis of Large-Scale NMR Data Generates Metabolomic Signatures and Links Them to Candidate Metabolites Open
Identification of metabolites in large-scale 1H NMR data from human biofluids remains challenging due to the complexity of the spectra and their sensitivity to pH and ionic concentrations. In this work, we tested the capacity of three anal…
View article: Automated analysis of large-scale NMR data generates metabolomic signatures and links them to candidate metabolites
Automated analysis of large-scale NMR data generates metabolomic signatures and links them to candidate metabolites Open
Identification of metabolites in large-scale 1 H NMR data from human biofluids remains challenging due to the complexity of the spectra and their sensitivity to pH and ionic concentrations. In this work, we test the capacity of three analy…
View article: PhenoMeNal: processing and analysis of metabolomics data in the cloud
PhenoMeNal: processing and analysis of metabolomics data in the cloud Open
Background Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological, and many…
View article: PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud
PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud Open
Background Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism’s metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological and many …
View article: Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks
Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks Open
In mating fission yeast cells, sensing and response to extracellular pheromone concentrations occurs through an exploratory Cdc42 patch that stochastically samples the cell cortex before stabilizing towards a mating partner. Active Ras1 (R…
View article: Inhibition of Ras activity coordinates cell fusion with cell–cell contact during yeast mating
Inhibition of Ras activity coordinates cell fusion with cell–cell contact during yeast mating Open
In the fission yeast Schizosaccharomyces pombe, pheromone signaling engages a signaling pathway composed of a G protein–coupled receptor, Ras, and a mitogen-activated protein kinase (MAPK) cascade that triggers sexual differentiation and g…
View article: Feedback inhibition of Ras activity coordinates cell fusion with cell-cell contact
Feedback inhibition of Ras activity coordinates cell fusion with cell-cell contact Open
In fission yeast Schizosaccharomyces pombe , pheromone signalling engages a GPCR-Ras-MAPK cascade to trigger sexual differentiation leading to gamete fusion. Cell-cell fusion necessitates local cell wall digestion, the location of which re…