Bing Chen
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View article: Molecular subtype-driven disparities in intraoperative touch imprint cytology accuracy for sentinel lymph node assessment in clinically node-positive breast cancer treated with neoadjuvant chemotherapy
Molecular subtype-driven disparities in intraoperative touch imprint cytology accuracy for sentinel lymph node assessment in clinically node-positive breast cancer treated with neoadjuvant chemotherapy Open
Collectively, our study demonstrates that ITPC exhibits a robust accuracy for detecting SLN metastases in cN + breast cancer patients treated with NAC. The findings support the implementation of molecular subtype-specific SLN management: I…
View article: Unilateral biportal endoscopic with modified arcocristectomy for pinching cervical spondylotic myelopathy: surgical technique and early experiences
Unilateral biportal endoscopic with modified arcocristectomy for pinching cervical spondylotic myelopathy: surgical technique and early experiences Open
Objectives Introduce the surgical technique and early clinical efficacy of the modified arcocristectomy for treating pinching cervical spondylotic myelopathy using unilateral approach for bilateral decompression under cervical unilateral b…
View article: Exploring the Mechanisms of Gastroesophageal Reflux Disease Based on the Brain-Gut Axis Theory
Exploring the Mechanisms of Gastroesophageal Reflux Disease Based on the Brain-Gut Axis Theory Open
Gastroesophageal reflux disease (GERD) is a common clinical digestive disorder with a complex pathological mechanism. Traditional understanding of its mechanisms primarily focuses on factors such as lower esophageal sphincter dysfunction, …
View article: International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials Open
This work was supported by the National Natural Science Foundation of China, the German Research Foundation (DFG) via the Cluster of Excellence, and others.
View article: Predicting bone metastasis and high-grade Gleason scores in prostate cancer: a retrospective study integrating clinical features and magnetic resonance imaging radiomics
Predicting bone metastasis and high-grade Gleason scores in prostate cancer: a retrospective study integrating clinical features and magnetic resonance imaging radiomics Open
We proposed a predictive model that integrated clinical features and radiomics features obtained from prostate MRI, offering a non-invasive and radiation-free approach to predict bone metastasis and high-grade Gleason scores in PCa.
View article: HDAC3 Regulates Ferroptosis via Nrf2–GPX4 Signaling in Colorectal Cancer Cells
HDAC3 Regulates Ferroptosis via Nrf2–GPX4 Signaling in Colorectal Cancer Cells Open
Ferroptosis, an iron-dependent form of regulated cell death, represents an emerging therapeutic vulnerability in colorectal cancer (CRC). However, the epigenetic mechanisms controlling ferroptosis sensitivity in CRC remain poorly understoo…
View article: Study on the Response of Cotton Leaf Color to Plant Water Content Changes and Optimal Irrigation Thresholds
Study on the Response of Cotton Leaf Color to Plant Water Content Changes and Optimal Irrigation Thresholds Open
Real-time monitoring of cotton moisture status and determination of appropriate irrigation thresholds are essential for achieving precision irrigation. Currently employed diagnostic methods based on physiological indicators, remote sensing…
View article: Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9
Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9 Open
This work was funded by the National Natural Science Foundation of China.
View article: The Impact of Fulvic Acids on Cotton Growth, Yield and Phosphorus Fertilizer Use Efficiency Under Different Phosphorus Fertilization Rates in Xinjiang, China
The Impact of Fulvic Acids on Cotton Growth, Yield and Phosphorus Fertilizer Use Efficiency Under Different Phosphorus Fertilization Rates in Xinjiang, China Open
Chemical phosphorus (P) fertilizer is often overused in arid regions with alkaline soils due to soil fixation. Fulvic acid (FA) can increase soil P availability, enhancing crop yield and P use efficiency, but its interaction with P fertili…
View article: Fulvic Acid Enhances Cotton Yield and Phosphorus Use Efficiency Under Different Application Rates of Phosphorus Fertilizers
Fulvic Acid Enhances Cotton Yield and Phosphorus Use Efficiency Under Different Application Rates of Phosphorus Fertilizers Open
Chemical phosphorus (P) fertilizer is often overused in arid regions with alkaline soils due to soil fixation. Fulvic acid (FA) has been reported to increase soil P availability, thus enhancing crop growth, yield and P use efficiency, but …
View article: The effect of prognostic nutritional indices on stroke hospitalization outcomes
The effect of prognostic nutritional indices on stroke hospitalization outcomes Open
Higher PNI is associated with better hospitalization outcomes for stroke patients. PNI can be used as a supplement to existing indicators, which helps predict the survival of stroke inpatients and provides reference value for clinical trea…
View article: RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer
RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer Open
RNA splicing is a critical process governing gene expression and transcriptomic diversity. Despite its importance, a detailed examination of transcript variation at the splicing junction level remains scarce. Here, we perform a thorough an…
View article: Expert consensus on culture of patient derived tumor organoids and organoids based drug sensitivity testing
Expert consensus on culture of patient derived tumor organoids and organoids based drug sensitivity testing Open
The precision treatment of cancer has consistently been a significant issue in clinical management as well as medical research. With the rapid development and advances towards clinical application of organoids technology, the use of organo…
View article: Ultrasonic Array-Based Multi-Source Fusion Indoor Positioning Technology
Ultrasonic Array-Based Multi-Source Fusion Indoor Positioning Technology Open
Underground mining involves numerous risks, such as collapses, gas leaks, and explosions, posing significant threats to worker safety. In this work, we develop an indoor localization system that uses Bluetooth for coarse positioning and ul…
View article: UWB-Assisted Bluetooth Localization Using Regression Models and Multi-Scan Processing
UWB-Assisted Bluetooth Localization Using Regression Models and Multi-Scan Processing Open
Bluetooth devices have been widely used for pedestrian positioning and navigation in complex indoor scenes. Bluetooth beacons are scattered throughout the entire indoor walkable area containing stairwells, and pedestrian positioning can be…
View article: Students’ Intention to Adopt E-learning Platform for College English Study: Mediating Effect of Satisfaction of Basic Psychological Needs
Students’ Intention to Adopt E-learning Platform for College English Study: Mediating Effect of Satisfaction of Basic Psychological Needs Open
E-learning platform (ELP) provides economic and efficient channels to share and learn knowledge online without time and location restrictions. Earlier studies have identified determinants that impact students’ intention to use new technolo…
View article: The Optimal Head Position Following Intratympanic Injection: A Research Based on HRCT Reconstruction
The Optimal Head Position Following Intratympanic Injection: A Research Based on HRCT Reconstruction Open
Objective: This study aimed to investigate the optimal head position (OHP) following intratympanic injection, a critical intervention in treating inner ear disorders. Identifying OHP is essential to maximize drug retention in the middle ea…
View article: MEK/ERK signaling drives the transdifferentiation of supporting cells into functional hair cells by modulating the Notch pathway
MEK/ERK signaling drives the transdifferentiation of supporting cells into functional hair cells by modulating the Notch pathway Open
Loss of cochlear hair cells (HCs) leads to permanent hearing loss in mammals, and regenerative medicine is regarded as an ideal strategy for hearing recovery. Limited genetic and pharmaceutical approaches for HC regeneration have been esta…
View article: RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer
RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer Open
RNA splicing is a critical process governing gene expression and transcriptomic diversity. Despite its importance, a detailed examination of transcript variation at the splicing junction level remains scarce. Here, we perform a thorough an…
View article: Altered brain function in classical trigeminal neuralgia patients: ALFF, ReHo, and DC static- and dynamic-frequency study
Altered brain function in classical trigeminal neuralgia patients: ALFF, ReHo, and DC static- and dynamic-frequency study Open
The present study aimed to clarify the brain function of classical trigeminal neuralgia (CTN) by analyzing 77 CTN patients and age- and gender-matched 73 healthy controls (HCs) based on three frequency bands of the static and dynamic ampli…
View article: Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates Open
Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss 9 (DFNB9), one of the most common forms of auditory neuropathy. There is no biological treatment for DFNB9. Here, we designed an OTOF gene therapy agent by dual A…
View article: Which Came First, Age-Related Hearing Loss with Tinnitus or Cognitive Impairment? What are the Potential Pathways?
Which Came First, Age-Related Hearing Loss with Tinnitus or Cognitive Impairment? What are the Potential Pathways? Open
Research on the causal relationship between age-related hearing loss (ARHL) and/or tinnitus and dementia is an important and fast-moving field. In this opinion paper, the up-to-date evidence and potential mechanisms for the bidirectional r…
View article: Predicting students’ continued intention to use E-learning platform for college English study: the mediating effect of E-satisfaction and habit
Predicting students’ continued intention to use E-learning platform for college English study: the mediating effect of E-satisfaction and habit Open
Using technology in education facilitates knowledge dissemination expediently while broadening and deepening learning modes and content diversity. As an information technological innovation, E-learning platform is widely used to learn coll…
View article: Response of Guobu Slope Displacement to Rainfall and Reservoir Water Level with Time-Series InSAR and Wavelet Analysis
Response of Guobu Slope Displacement to Rainfall and Reservoir Water Level with Time-Series InSAR and Wavelet Analysis Open
Reservoir bank landslides are a frequent phenomenon, and the stability of these landslides is affected by two essential factors: rainfall and reservoir level changes. Studying the response patterns of reservoir bank landslide movements to …