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Resistance, heteroresistance, and fitness costs drive colistin treatment failure during <i>Acinetobacter baumannii</i> pneumonia Open
Acinetobacter baumannii is an Enterococcus , Staphylococcus , Klebsiella , Acinetobacter , Pseudomonas , and Enterobacter species (ESKAPE) pathogen linked to healthcare-associated diseases. Due to evolved resistance, last-resort antibiotic…
Resistance, heteroresistance and fitness costs drive colistin treatment failure during <i>Acinetobacter baumannii</i> pneumonia Open
Acinetobacter baumannii is an ESKAPE pathogen linked to healthcare-associated diseases. Due to evolved resistance, last-resort antibiotics such as the lipooligosaccharide (LOS)-targeting colistin are increasingly used to treat multidrug-re…
View article: The TerC family metal chaperone MeeY enables surfactin export in <i>Bacillus subtilis</i>
The TerC family metal chaperone MeeY enables surfactin export in <i>Bacillus subtilis</i> Open
TerC family proteins are widely conserved integral membrane proteins with functions related to metal transport. In Bacillus subtilis , the TerC proteins MeeF and MeeY play overlapping roles in the metalation of manganese-requiring membrane…
Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis Open
Cell physiology requires innumerable metalloenzymes supported by the selective import of metal ions. Within the crowded cytosol, most enzymes acquire their cognate cofactors from a buffered labile pool. Metalation of membrane-bound and sec…
TerC proteins function during protein secretion to metalate exoenzymes Open
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC family proteins function in metalation of enzymes during export…
TerC Proteins Function During Protein Secretion to Metalate Exoenzymes Open
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC family proteins function in metalation of enzymes during export…
TerC Proteins Function During Protein Secretion to Metalate Exoenzymes Open
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC family proteins function in metalation of enzymes during export…