Bo Chen
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View article: Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis
Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis Open
Non‐small cell lung cancer (NSCLC) is the leading cause of brain metastases (BMs) and is characterized by a poor prognosis and limited response to standard treatments. Multi‐omics sequencings, integrating spatial transcriptomics, metabolom…
View article: Comparative Functional Analysis of COLD1 and GPA1 in Processing Tomatoes: Overexpression of COLD1 Significantly Enhances Seedling Cold Tolerance and Physiological Responses
Comparative Functional Analysis of COLD1 and GPA1 in Processing Tomatoes: Overexpression of COLD1 Significantly Enhances Seedling Cold Tolerance and Physiological Responses Open
Low temperature severely limits tomato (Solanum lycopersicum) production, yet the molecular mechanisms governing cold tolerance—particularly those involving COLD1 and GPA1—remain incompletely defined. To address this, processing tomato lin…
View article: LncRNA CTB-31O20.2 promotes the progression of hepatocellular carcinoma by targeting the miR-139-5p/ROCK1 axis
LncRNA CTB-31O20.2 promotes the progression of hepatocellular carcinoma by targeting the miR-139-5p/ROCK1 axis Open
Hepatocellular carcinoma (HCC) is a primary cause of mortality from cancer, necessitating novel insights into its molecular underpinnings. Recent evidence points to the significant roles of lncRNAs in HCC progression, among which CTB-31O20…
View article: Effects of repetitive transcranial magnetic stimulation on electroencephalographical measures of post-stroke upper limb dysfunction: study protocol for a randomized controlled trial
Effects of repetitive transcranial magnetic stimulation on electroencephalographical measures of post-stroke upper limb dysfunction: study protocol for a randomized controlled trial Open
Background Patients with stroke would experience upper limb dysfunction, leading to functional impairments in daily living and placing a burden on society and families. Repetitive transcranial magnetism stimulation (rTMS), a non-invasive n…
View article: Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank
Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank Open
Phenotypic age acceleration (PhenoAgeAccel) is a novel biological indicator estimates an individual's mortality risk. The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovasc…
View article: Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of odor components between two Ferula species
Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of odor components between two Ferula species Open
The present study expands our knowledge of the volatile metabolic profiles of the two Ferula species and lays the foundation for further studies on the regulatory mechanisms of Ferula quality.
View article: Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid
Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid Open
BACKGROUND Intermittent fasting (IF), particularly time-restricted feeding (TRF), is increasingly popular has gained popularity for weight loss, yet management, but its effects impact on gut health remain unclear. Remains inadequately unde…
View article: STEAP3 alleviates inflammation and fibrosis via iron metabolism in ischemia/reperfusion-associated lung injury
STEAP3 alleviates inflammation and fibrosis via iron metabolism in ischemia/reperfusion-associated lung injury Open
Lower limb ischemia/reperfusion (LIRI)-associated lung injury is a common complication observed in patients with lower extremity occlusion and prolonged tourniquet exposure, leading to significant morbidity and mortality. The lung is the p…
View article: Trends in Combinatorial Endocrine Therapy for Breast Cancer Across Six Cities in China(2016-2021)
Trends in Combinatorial Endocrine Therapy for Breast Cancer Across Six Cities in China(2016-2021) Open
The use of endocrine therapy drugs has increased, with AI being the most frequently used. Additionally, the combination of AI and OFS has become the most prevalent treatment approach.
View article: A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity
A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity Open
Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, the mechanisms by which they foster a protumorigenic immune environment remain poorly understo…
View article: Association between reactive cutaneous capillary endothelial proliferation and the efficacy of camrelizumab in esophageal cancer: a retrospective cohort study
Association between reactive cutaneous capillary endothelial proliferation and the efficacy of camrelizumab in esophageal cancer: a retrospective cohort study Open
In the EC patients treated with camrelizumab, those with RCCEP had significantly better outcomes in terms of the ORR, DCR, PFS, and OS than those without RCCEP. The emergence of RCCEP may serve as a potential predictor for the therapeutic …
View article: Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various machine learning algorithms
Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various machine learning algorithms Open
Objective This study aims to construct an effective prediction model for the two-year postoperative survival probability of patients with non-small cell lung cancer (NSCLC). It particularly focuses on integrating radiomics features, includ…
View article: Inhibiting CSF1R signaling reduces disc degeneration and discogenic back pain
Inhibiting CSF1R signaling reduces disc degeneration and discogenic back pain Open
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain. Inflammation has been implicated in discogenic back pain and disc degeneration, however, the detailed molecular mechanisms remain unclear. Herein we demons…
View article: Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition
Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition Open
Background Selinexor is a selective inhibitor of exportin-1 (XPO1), a key mediator of the nucleocytoplasmic transport for molecules critical to tumor cell survival. Selinexor’s lethality is generally associated with the induction of apopto…
View article: Predicting 5-Year Survival in Gastric Cancer Patients Using Iliopsoas Muscle CT Radiomics and Machine Learning Techniques
Predicting 5-Year Survival in Gastric Cancer Patients Using Iliopsoas Muscle CT Radiomics and Machine Learning Techniques Open
Objectives Sarcopenia, linked to postoperative survival in cancer patients, was investigated in this study. The research explored the relationship between CT imaging features of muscles in gastric cancer patients and their survival. Additi…
View article: Biochanin A Induces Apoptosis in MCF‐7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
Biochanin A Induces Apoptosis in MCF‐7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition Open
The study aimed to investigate the molecular mechanisms by which Biochanin A inhibits proliferation and induces apoptosis in breast cancer cells. Cultured MCF‐7 cells were divided into four groups: Group 1‐control, while Groups 2, 3, and 4…
View article: Comparison of Superselective Renal Artery Embolization versus Retroperitoneal Laparoscopic Partial Nephrectomy in Ruptured Hemorrhagic Renal Angiomyolipoma: A Single-Center Study
Comparison of Superselective Renal Artery Embolization versus Retroperitoneal Laparoscopic Partial Nephrectomy in Ruptured Hemorrhagic Renal Angiomyolipoma: A Single-Center Study Open
Purpose: To analyze the clinical efficacy of superselective renal artery embolization and retroperitoneal laparoscopic partial nephrectomy for the treatment of ruptured hemorrhagic renal angiomyolipoma and to provide a reference for the se…
View article: Sirtuin 5 (SIRT5) Suppresses Tumor Growth by Regulating Mitochondrial Metabolism and Synaptic Remodeling in Gliomas
Sirtuin 5 (SIRT5) Suppresses Tumor Growth by Regulating Mitochondrial Metabolism and Synaptic Remodeling in Gliomas Open
Sirtuin 5 (SIRT5) is increasingly recognized as a key regulator of cellular metabolism, which is commonly dysregulated in cancer cells, resulting in enhanced proliferation and tumor progression. To investigate the clinicopathologic implica…
View article: BOC targets SMO to regulate the Hedgehog pathway and promote proliferation, migration, and invasion of glioma cells
BOC targets SMO to regulate the Hedgehog pathway and promote proliferation, migration, and invasion of glioma cells Open
The purpose of this study was to investigate the effects of BOC on glioblastoma cells and its underlying mechanisms. In vitro, BOC-knockdown was performed in glioma cell lines. CCK-8 and Transwell were used to assess the impact of BOC on t…
View article: Integrative analysis identifies molecular features of fibroblast and the significance of fibrosis on neoadjuvant chemotherapy response in breast cancer
Integrative analysis identifies molecular features of fibroblast and the significance of fibrosis on neoadjuvant chemotherapy response in breast cancer Open
Background: The molecular features of fibroblasts and the role of fibrosis in neoadjuvant chemotherapy (NAC) response and breast cancer (BRCA) prognosis remain unclear. Therefore, this study aimed to investigate the impact of interstitial …
View article: Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation
Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation Open
Purpose Tortuosity of the internal carotid artery (ICA) is associated with intracranial aneurysms (IAs). The siphon is the most curved segment of the ICA, but its morphology has controversial effects on IAs. This study aimed to explore the…
View article: Individualized detection of TMPRSS2-ERG fusion status in prostate cancer: a rank-based qualitative transcriptome signature
Individualized detection of TMPRSS2-ERG fusion status in prostate cancer: a rank-based qualitative transcriptome signature Open
Background TMPRSS2-ERG (T2E) fusion is highly related to aggressive clinical features in prostate cancer (PC), which guides individual therapy. However, current fusion prediction tools lacked enough accuracy and biomarkers were unable to b…
View article: Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study
Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study Open
Recent evidence suggests that allergic asthma (AA) decreases the risk of Coronavirus Disease 2019 (COVID-19). However, the reasons remain unclear. Here, we systematically explored data from GWAS (18 cohorts with 11,071,744 samples), bulk t…