Biyi Chen
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View article: Mechanisms and Applications of Nature-Based Solutions for Stormwater Control in the Context of Climate Change: A Review
Mechanisms and Applications of Nature-Based Solutions for Stormwater Control in the Context of Climate Change: A Review Open
Nature-based solutions (NbSs) are considered to form an innovative stormwater management approach that has living resolutions grounded in natural processes and structures. NbSs offer many other environmental benefits over traditional grey …
View article: Changes in Concurrent Meteorological Extremes of Rainfall and Heat under Divergent Climatic Trajectories in the Guangdong–Hong Kong–Macao Greater Bay Area
Changes in Concurrent Meteorological Extremes of Rainfall and Heat under Divergent Climatic Trajectories in the Guangdong–Hong Kong–Macao Greater Bay Area Open
Concurrent meteorological extremes (CMEs) represent a class of pernicious climatic events characterized by the coexistence of two extreme weather phenomena. Specifically, the juxtaposition of Urban Extreme Rainfall (UER) and Urban Extreme …
View article: Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control
Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control Open
Aims A mechanistic link between depression and risk of arrhythmias could be attributed to altered catecholamine metabolism in the heart. Monoamine oxidase-A (MAO-A), a key enzyme involved in catecholamine metabolism and longstanding antide…
View article: Polymer Photocatalysts Containing Segregated π‐Conjugation Units with Electron‐Trap Activity for Efficient Natural‐light‐driven Bacterial Inactivation
Polymer Photocatalysts Containing Segregated π‐Conjugation Units with Electron‐Trap Activity for Efficient Natural‐light‐driven Bacterial Inactivation Open
Development of highly efficient and metal‐free photocatalysts for bacterial inactivation under natural light is a major challenge in photocatalytic antibiosis. Herein, we developed an acidizing solvent‐thermal approach for inserting a non‐…
View article: CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling
CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling Open
Background: Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for stroke, and is associated with pronounced morbidity and death. Genes uniquely expressed in the…
View article: Hepatic IRE1 Protects Against Septic Cardiac Failure
Hepatic IRE1 Protects Against Septic Cardiac Failure Open
SUMMARY Metabolic reprogramming in response to infection plays a critical role for septic survival. During a septic episode, the heart heavily relies on hepatic lipid particles to prevent heart damage and failure. Inositol- Requiring Enzym…
View article: Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control
Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control Open
Background People with clinical depression exhibit increased risk for cardiac arrhythmias that could be related to differences in catecholamine metabolism. Emerging studies have implicated a pathophysiologic role for monoamine oxidase (MAO…
View article: Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure
Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure Open
Background The lysosome is a central player in maintaining immuno-metabolic homeostasis. However, mechanistic insights into the regulation of lysosome-dependent immuno-metabolism in the heart are lacking. Lysosomal reductase Gamma Interfer…
View article: Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome
Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome Open
Background Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). The metabolic derangement and underlying mechanisms of cardio‐encephalomyopathy in LS remains incompletely un…
View article: Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome
Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome Open
Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). We report that LS mice also develop severe cardiac bradyarrhythmia and diastolic dysfunction. Human induced pluripotent …
View article: Atrial-paced, exercise-similar heart rate envelope induces myocardial protection from ischaemic injury
Atrial-paced, exercise-similar heart rate envelope induces myocardial protection from ischaemic injury Open
Aims The study investigates the role and mechanisms of clinically translatable exercise heart rate (HR) envelope effects, without dyssynchrony, on myocardial ischaemia tolerance compared to standard preconditioning methods. Since the magni…
View article: Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy Open
Calpain proteolysis contributes to the pathogenesis of heart failure but the calpain isoforms responsible and their substrate specificities have not been rigorously defined. One substrate, Junctophilin-2 (JP2), is essential for maintaining…
View article: A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells
A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells Open
Micropeptides (microproteins) encoded by transcripts previously annotated as long noncoding RNAs (lncRNAs) are emerging as important mediators of fundamental biological processes in health and disease. Here, we applied two computational to…
View article: Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms Open
Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF. However, the mechanism(s) underlying this clinical association is unknown. ROS and protein O-…
View article: A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells
A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells Open
Micropeptides (microproteins) encoded by transcripts previously annotated as long noncoding RNA (IncRNAs) are emerging as important mediators of fundamental biological processes in health and disease. Here we applied two computational tool…
View article: Integrin β1D Deficiency–Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin β1D Deficiency–Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy Open
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary heart disease characterized by fatty infiltration, life-threatening arrhythmias, and increased risk of sudden cardiac death. The guideline for management of…
View article: <i>O</i>-GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanisms
<i>O</i>-GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanisms Open
Diabetes mellitus and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF in patients. However, the mechanism(s) underlying this clinical association is unknown. Elevated pr…
View article: E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator
E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator Open
Protecting the heart Excitation-contraction (E-C) coupling is fundamental to heart contraction. Junctophilin-2 is a structural protein required for formation of the E-C coupling machinery. During heart disease, stress-activated calpain cle…
View article: Targeting Calpain for Heart Failure Therapy
Targeting Calpain for Heart Failure Therapy Open
Heart failure remains a major cause of morbidity and mortality in developed countries. There is still a strong need to devise new mechanism-based treatments for heart failure. Numerous studies have suggested the importance of the Ca2+-depe…
View article: Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia
Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia Open
Our studies demonstrate that binge alcohol exposure activates JNK2 in atria, which then drives CaMKII activation, prompting aberrant Ca2+ waves and, thus, enhanced susceptibility to atrial arrhythmia. Our results reveal a previously unreco…
View article: Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis
Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis Open
Rationale: Atrial fibrillation (AF) is the most common arrhythmia, and advanced age is an inevitable and predominant AF risk factor. However, the mechanisms that couple aging and AF propensity remain unclear, making targeted therapeutic in…
View article: Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure
Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure Open
Widespread changes in cardiac gene expression occur during heart failure, yet the mechanisms responsible for coordinating these changes remain poorly understood. The Mediator complex represents a nodal point for modulating transcription by…
View article: Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo
Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo Open
Rationale: Loss-of-function studies in cardiac myocytes (CMs) are currently limited by the need for appropriate conditional knockout alleles. The factors that regulate CM maturation are poorly understood. Previous studies on CM maturation …
View article: Critical Roles of STAT3 in β-Adrenergic Functions in the Heart
Critical Roles of STAT3 in β-Adrenergic Functions in the Heart Open
Background— β-Adrenergic receptors (βARs) play paradoxical roles in the heart. On one hand, βARs augment cardiac performance to fulfill the physiological demands, but on the other hand, prolonged activations of βARs exert deleterious effec…
View article: Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: implications for the treatment of brain arteriovenous malformations
Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: implications for the treatment of brain arteriovenous malformations Open
OBJECT Stereotactic radiosurgery (SRS) is an established intervention for brain arteriovenous malformations (AVMs). The processes of AVM vessel occlusion after SRS are poorly understood. To improve SRS efficacy, it is important to understa…