Biyu Gui
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View article: Mitochondrial pyruvate metabolism in club cells drives airway inflammation
Mitochondrial pyruvate metabolism in club cells drives airway inflammation Open
Asthma is a chronic inflammatory airway disease characterized by defective epithelial repair, resulting from metabolic dysregulation in facultative progenitor cells. Here, we investigate how pyruvate metabolism in airway club cells control…
View article: PM2.5 Induces Cell-Specific Transcriptomic Alterations in the Lungs of Juvenile Mice
PM2.5 Induces Cell-Specific Transcriptomic Alterations in the Lungs of Juvenile Mice Open
These findings reveal cell-type-specific transcriptomic responses to PM2.5 in juvenile lungs, emphasizing its potential to disrupt immune homeostasis and contribute to pulmonary disease development in children.
View article: Cross-species comparison of airway epithelium transcriptomics
Cross-species comparison of airway epithelium transcriptomics Open
Studies of lung transcriptomics across species are essential for understanding the complex biology and disease mechanisms of this vital organ. Single-cell RNA sequencing (scRNA-seq) has emerged as a key tool for understanding cell dynamics…