Bjoern Sander
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View article: HyTIR – an airborne hyperspectral imaging research platform in the LWIR wavelength range
HyTIR – an airborne hyperspectral imaging research platform in the LWIR wavelength range Open
Hyperspectral cameras play a crucial role in remote sensing across various applications. The sensors designed for the visible to near-infrared (VNIR) and short-wave infrared (SWIR) ranges are particularly valuable due to their ability to d…
View article: Cytogenetic signatures favoring metastatic organotropism in colorectal cancer
Cytogenetic signatures favoring metastatic organotropism in colorectal cancer Open
Colorectal carcinoma (CRC) exhibits metastatic organotropism, primarily targeting liver, lung, and rarely the brain. Here, we study chromosomal imbalances (CIs) in cohorts of primary CRCs and metastases. Brain metastases show the highest b…
View article: Structural Organization of Human Full-Length PAR3 and the aPKC–PAR6 Complex
Structural Organization of Human Full-Length PAR3 and the aPKC–PAR6 Complex Open
View article: Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer
Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer Open
Aim Colorectal carcinomas (CRCs) progress through heterogeneous pathways. The aim of this study was to analyse whether or not the cytogenetic evolution of CRC is linked to tumour site, level of chromosomal imbalance and metastasis. Method …
View article: E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements Open
Loss of E-cadherin expression due to mutation of the CDH1 gene is a characteristic feature of invasive lobular breast cancer (ILBC). Beta-catenin, which binds to the cytoplasmic domain of E-cadherin, is simultaneously downregulated, reflec…
View article: Models of the complement C1 complex
Models of the complement C1 complex Open
Almitairi et al. (1) present structural information on the interaction between the proteases C1r and C1s, both consisting of six domains, called CUB1-EGF-CUB2-CCP1-CCP2-SP. The authors also propose a model for the C1 complex where the C1r2…
View article: Folding and assembly defects of pyruvate dehydrogenase deficiency-related variants in the E1α subunit of the pyruvate dehydrogenase complex
Folding and assembly defects of pyruvate dehydrogenase deficiency-related variants in the E1α subunit of the pyruvate dehydrogenase complex Open
View article: Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle<i>Trachemys scripta</i>: implications for antioxidant defense and O<sub>2</sub>transport
Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle<i>Trachemys scripta</i>: implications for antioxidant defense and O<sub>2</sub>transport Open
The ability of many reptilian hemoglobins (Hbs) to form high-molecular weight polymers, albeit known for decades, has not been investigated in detail. Given that turtle Hbs often contain a high number of cysteine (Cys), potentially contrib…
View article: Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r <sub>2</sub> s <sub>2</sub> tetramer
Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r <sub>2</sub> s <sub>2</sub> tetramer Open
Arlaud et al. (1) raised concerns regarding our small-angle X-ray scattering (SAXS) and EM models of the unbound C1r2s2 tetramer (2). They reference studies supporting an interaction of two C1rs dimers via C1r CCP1–serine protease (SP) int…
View article: Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid‐papillary carcinoma
Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid‐papillary carcinoma Open
Recently, a new variant of invasive lobular breast cancer (ILBC) with solid‐papillary‐like growth pattern has been described. We present a case of ILBC with solid‐papillary‐like growth pattern in the main tumour mass and classical invasive…
View article: Stepwise assembly of functional C‐terminal REST/NRSF transcriptional repressor complexes as a drug target
Stepwise assembly of functional C‐terminal REST/NRSF transcriptional repressor complexes as a drug target Open
In human cells, thousands of predominantly neuronal genes are regulated by the repressor element 1 (RE1)‐silencing transcription factor/neuron‐restrictive silencer factor (REST/NRSF). REST/NRSF represses transcription of these genes in ste…
View article: In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons
In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons Open
Huntington's disease (HD) results from a CAG repeat expansion in the gene encoding the huntingtin protein. This inherited disorder is characterized by progressive neurodegeneration. In particular, HD progression involves the loss of striat…