Explanipedia

Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In‐Vivo 1 H ‐ MR Spectroscopy Investigation Open

Simon Schading‐Sassenhausen, Anna Lebret, Kadir Şimşek, Pauline Gut, Sabrina Imhof , et al. · 2025

Spinal cord injury (SCI) disrupts spinal tracts and neuronal pathways, including those in the primary motor cortex (M1) and the lumbar cord enlargement (LCE) involved in motor control. This study sought to determine whether metabolite conc…

Quantification of Lower Limb Kinematics During Swimming in Individuals with Spinal Cord Injury Open

Melina Giagiozis, Sabrina Imhof, Sibylle Achermann, Catherine R. Jutzeler, László Demkó , et al. · 2025

Spinal cord injuries (SCI) often result in impaired motor functions. To quantify these impairments, swimming patterns were analyzed in individuals with SCI. Water provides a unique rehabilitation environment where buoyancy supports weight-…

Evidence for reticulospinal plasticity underlying motor recovery in Brown-Séquard-plus Syndrome: a case report Open

Antonia Maria Eilfort, Maria Rasenack, Björn Zörner, Armin Curt, Linard Filli · 2024

Brown-Séquard Syndrome (BSS) is a rare neurological condition caused by a unilateral spinal cord injury (SCI). Upon initial ipsilesional hemiplegia, patients with BSS typically show substantial functional recovery over time. Preclinical st…

Reliability of patient-specific gait profiles with inertial measurement units during the 2-min walk test in incomplete spinal cord injury Open

Romina Willi, Charlotte Werner, László Demkó, Rob de Bie, Linard Filli , et al. · 2024

Study protocol: short against long antibiotic therapy for infected orthopedic sites — the randomized-controlled SALATIO trials Open

İlker Uçkay, Stephan Wirth, Björn Zörner, Sandro F. Fucentese, Karl Wieser , et al. · 2023

Study Protocol: Short Against Long Antibiotic Therapy for Infected Orthopaedic Sites - SALATIO Trials Open

İlker Uçkay, Stephan Wirth, Björn Zörner, Sandro F. Fucentese, Karl Wieser , et al. · 2022

Validity and reliability of the 2-minute walk test in individuals with spinal cord injury Open

Romina Willi, Mario Widmer, Nora Merz, Caroline H. G. Bastiaenen, Björn Zörner , et al. · 2022

Study design Multicentre-observational study. Objectives The 6-minute walk test (6mWT) is an established assessment of walking function in individuals with spinal cord injury (SCI). However, walking 6 min can be demanding for severely impa…

Prognosis of walking function in multiple sclerosis supported by gait pattern analysis Open

Björn Zörner, Pascal Hostettler, Christian Meyer, Tim Killeen, Pauline Gut , et al. · 2022

Targeted Walking in Incomplete Spinal Cord Injury: Role of Corticospinal Control Open

Christian Meyer, Linard Filli, Stephanie A. Stalder, Chris Awai Easthope, Tim Killeen , et al. · 2020

Locomotor recovery after incomplete spinal cord injury (iSCI) is influenced by spinal and supraspinal networks. Conventional clinical gait analysis fails to differentiate between these components. There is evidence that corticospinal contr…

Fampridine-induced changes in walking kinetics are associated with clinical improvements in patients with multiple sclerosis Open

David Weller, Lilla Lőrincz, Tabea Sutter, Katja Reuter, Michael Linnebank , et al. · 2020

Gait dysfunction is common in patients with multiple sclerosis (PwMS). Treatment with prolonged-release fampridine (PR-fampridine) improves walking ability in some PwMS. Associated fampridine-induced changes in the walking pattern are stil…

Familiarization with treadmill walking: How much is enough? Open

Christian Meyer, Tim Killeen, Chris Awai Easthope, Armin Curt, Marc Bolliger , et al. · 2019

Treadmill-based gait analysis is widely used to investigate walking pathologies and quantify treatment effects on locomotion. Differential sensorimotor conditions during overground vs. treadmill walking necessitate initial familiarization …

Probing Corticospinal Control During Different Locomotor Tasks Using Detailed Time-Frequency Analysis of Electromyograms Open

Linard Filli, Christian Meyer, Tim Killeen, Lilla Lőrincz, Beat Göpfert , et al. · 2019

Locomotion relies on the fine-tuned coordination of different muscles which are controlled by particular neural circuits. Depending on the attendant conditions, walking patterns must be modified to optimally meet the demands of the task. A…

Arm swing asymmetry in overground walking Open

Tim Killeen, Morad Elshehabi, Linard Filli, Markus A. Hobert, Clint Hansen , et al. · 2018

Lower extremity outcome measures: considerations for clinical trials in spinal cord injury Open

Marc Bolliger, Andrew R. Blight, Edelle C. Field‐Fote, Kristin E. Musselman, Serge Rossignol , et al. · 2018

Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time Open

Linard Filli, Tabea Sutter, Chris Awai Easthope, Tim Killeen, Christian Meyer , et al. · 2018

Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patien…

Recurrent syncope due to carotid sinus hypersensitivity in cerebral atherosclerosis Open

Björn Zörner, Jan Steffel, Michael Linnebank, Alexander A. Tarnutzer · 2018

A 62-year-old female with a history of stroke due to cerebral arteriosclerosis suffered from recurrent fainting (<10s) provoked by rapid head movements up to four times per month for at least two years. There was no evidence of new strokes…

Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology Open

Benjamin Victor Ineichen, Sandra Kapitza, Christiane Bleul, Nicolas Good, Patricia S. Plattner , et al. · 2017

Minimum toe clearance: probing the neural control of locomotion Open

Tim Killeen, Chris Awai Easthope, László Demkó, Linard Filli, Lilla Lőrincz , et al. · 2017

Monitoring long-term efficacy of fampridine in gait-impaired patients with multiple sclerosis Open

Linard Filli, Björn Zörner, Sandra Kapitza, Katja Reuter, Lilla Lőrincz , et al. · 2017

Objective: To expand upon the limited knowledge of the long-term effects of prolonged-release (PR) fampridine in patients with multiple sclerosis (PwMS) regarding safety, walking improvements, and changes in drug responsiveness. Methods: F…

Increasing cognitive load attenuates right arm swing in healthy human walking Open

Tim Killeen, Chris Awai Easthope, Linard Filli, Lilla Lőrincz, Miriam Schrafl‐Altermatt , et al. · 2017

Human arm swing looks and feels highly automated, yet it is increasingly apparent that higher centres, including the cortex, are involved in many aspects of locomotor control. The addition of a cognitive task increases arm swing asymmetry …

Supplementary Table 1 from Increasing cognitive load attenuates right arm swing in healthy human walking Open

Tim Killeen, Christopher Easthope, Linard Filli, Lilla Lőrincz, Miriam Schrafl‐Altermatt , et al. · 2017

Mean ± SEM of gait parameters under three walking conditions on a treadmill; normal walking (no additional cognitive load), walking while performing a congruent Stroop task and walking while performing an incongruent Stroop task. Step leng…

Modulating Arm Swing Symmetry with Cognitive Load: A Window on Rhythmic Spinal Locomotor Networks in Humans? Open

Tim Killeen, Chris Awai Easthope, Linard Filli, Michael Linnebank, Armin Curt , et al. · 2016

In healthy subjects, changes in arm swing symmetry while walking are observed when a cognitive dual task is added, with a tendency toward left-dominant arm swing as cognitive load increases. We applied a modified Stroop word/color naming p…

Prolonged-release fampridine in multiple sclerosis: Improved ambulation effected by changes in walking pattern Open

Björn Zörner, Linard Filli, Katja Reuter, Sandra Kapitza, Lilla Lőrincz , et al. · 2016

Background: Prolonged-release fampridine (PR-fampridine, 4-aminopyridine) increases walking speed in the timed 25-foot walk test (T25FW) in some patients (timed-walk responders) with multiple sclerosis (MS). Objective: To explore the effec…

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