Thomas B. L. Kirkwood
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Tentative evidence that aging is caused by a small number of interacting processes Open
Human life expectancy has increased dramatically over the past two centuries, marking a significant public health achievement. While some projections predict a future where median lifespans reach 100 years, others contend that further long…
Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study Open
Immunosenescence, a decline in immune system function, has been linked to several age-related diseases and ageing syndromes. Very old adults (aged ≥ 85 years) live with multiple long-term conditions (MLTC, also known as multimorbidity)—a c…
View article: New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary Open
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the ori…
986 IMMUNOSENESCENCE PROFILES AND MULTIPLE LONG-TERM CONDITIONS IN VERY OLD ADULTS: THE NEWCASTLE 85+ STUDY Open
Introduction Immunosenescence, a decline in immune system function, has been linked to several age-related diseases and geriatric syndromes, including cardiovascular diseases and frailty. Very old adults (aged ≥85 years) live with multiple…
Aging as a consequence of selection to reduce the environmental risk of dying Open
Significance A fresh perspective on the evolution of aging is developed, which focuses on optimizing an individual’s exposure to mortality risk across the life course. A significant source of risk is associated with the act of acquiring th…
Senolytics and the compression of late-life mortality Open
Senescent cells play an important role in mammalian ageing and in the etiology of age-related diseases. Treatment of mice with senolytics – drugs that selectively remove senescent cells – causes an extension of median lifespan but has litt…
On the evolution of cellular senescence Open
The idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related diseases and extends the life span of mice. While efforts proceed to make thera…
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study Open
Decline in immune system function (immunosenescence) has been implicated in several age-related disorders. However, little is known about whether alteration in T-cell senescence, a process underlying immunological ageing, is related to mus…
8 Ageing and multi-morbidity Open
A growing fraction of the population is living to advanced old age, bringing increased prevalence of a wide range of age-related chronic diseases. Age is much the largest risk factor for a whole spectrum of different diseases, dwarfing the…
FONDATION IPSEN 2018 LONGEVITY PRIZE AWARD LECTURE: NIR BARZILAI Open
The IPSEN Foundation Longevity Prize was created in 1996 to recognise the global importance of the continuing increase in human life expectancy. This remarkable increase has implications for a very wide range of scientific disciplines as w…
New horizons in the compression of functional decline Open
Population ageing, which has come about through the combination of increases in life expectancy, larger post-war cohorts reaching older age and reductions in fertility, is challenging societies and particularly health and care providers, w…
Resolving the Enigma of the Clonal Expansion of mtDNA Deletions Open
Mitochondria are cell organelles that are special since they contain their own genetic material in the form of mitochondrial DNA (mtDNA). Damage and mutations of mtDNA are not only involved in several inherited human diseases but are also …
Do reef corals age? Open
Hydra is emerging as a model organism for studies of ageing in early metazoan animals, but reef corals offer an equally ancient evolutionary perspective as well as several advantages, not least being the hard exoskeleton which provides a r…
Is There a Link Between Cognitive Reserve and Cognitive Function in the Oldest-Old? Open
In the oldest-old, higher reserve associated with better baseline global and domain-specific cognitive function and reduced risk of prevalent dementia; but not cognitive decline or incident dementia. Increasing reserve could promote cognit…
FONDATION IPSEN LONGEVITY PRIZE 2017 AWARDING LECTURE Open
During this symposium, the Fondation Ipsen Longevity Prize 2017 will be awarded to Andrzej Bartke.
Longitudinal changes in global and domain specific cognitive function in the very‐old: findings from the Newcastle 85+ Study Open
Objective Ageing is associated with changes in cognition in some, but not all domains. In young–old adults, defined as persons aged 65–84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether simila…
Initial level and rate of change in grip strength predict all-cause mortality in very old adults Open
higher baseline GS and 5-year increase in GS were protective of mortality, whilst GS decline was associated with an increased risk of mortality in the very old over 9.6 years, especially in women. These results add to the biological and cl…
Grip strength and inflammatory biomarker profiles in very old adults Open
an inflammatory profile including hsCRP and albumin was independently associated with baseline GS. Future studies linking inflammatory profiles and muscle strength are needed to corroborate these findings in older adults.
Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study Open
Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and phy…
Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study Open
Introduction Recognition that an older person has sarcopenia is important because this condition is linked to a range of adverse outcomes. Sarcopenia becomes increasingly common with age, and yet there are few data concerning its descripti…
Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study Open
Grip strength decline in the very old followed linear (men) and curvilinear (women) trends. High levels of physical activity were protective of GS loss in men (but not in women) and in those with weak GS. Thus maintaining muscle strength i…
Can aging be programmed? A critical literature review Open
The evolution of the aging process has long been a biological riddle, because it is difficult to explain the evolution of a trait that has apparently no benefit to the individual. Over 60 years ago, Medawar realized that the force of natur…
Micronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study Open
A number of socio-economic, biological and lifestyle characteristics change with advancing age and place very old adults at increased risk of micronutrient deficiencies. The aim of this study was to assess vitamin and mineral intakes and r…