Blake D. Anson
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View article: Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor’s Disease Susceptibility
Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor’s Disease Susceptibility Open
SUMMARY Human induced pluripotent stem cells (hiPSCs) are frequently used to study disease-associated variations. We characterized transcriptional variability from a hiPSC-derived cardiomyocyte (hiPSC-CM) study of left ventricular hypertro…
View article: Human iPSC-Derived 2D and 3D Platforms for Rapidly Assessing Developmental, Functional, and Terminal Toxicities in Neural Cells
Human iPSC-Derived 2D and 3D Platforms for Rapidly Assessing Developmental, Functional, and Terminal Toxicities in Neural Cells Open
With increasing global health threats has come an urgent need to rapidly develop and deploy safe and effective therapies. A common practice to fast track clinical adoption of compounds for new indications is to repurpose already approved t…
View article: Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids
Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids Open
Human induced Pluripotent Stem Cells (iPSCs) are a powerful tool to dissect the biology of complex human cell types such as those of the central nervous system (CNS). However, robust, high-throughput platforms for reliably measuring activi…
View article: Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study Open
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, …
View article: Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-<i>β</i> Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation
Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-<i>β</i> Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation Open
Several progenitor cell populations have been reported to exist in hearts that play a role in cardiac turnover and/or repair. Despite the presence of cardiac stem and progenitor cells within the myocardium, functional repair of the heart a…
View article: Implementing Ipsc Technology: Case Studies Of Ipsc-Tissue Cell Use In Disease Modeling And Drug Discovery
Implementing Ipsc Technology: Case Studies Of Ipsc-Tissue Cell Use In Disease Modeling And Drug Discovery Open
Case studies on deriving iPSCs from clinical and non-clinical populations and using iPSC-tissue cells in disease modeling and drug discovery.Induced pluripotent stem cell (iPSC) technology is having a positive impact on drug discovery effo…