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View article: Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle
Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle Open
Metabolites are key regulators of cell fate decisions, epigenetic remodeling, and lineage commitment. While genetic pathways governing testis differentiation are well studied, the role of metabolism remains poorly understood. In this study…
View article: Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary
Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development
The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development Open
The bipotential gonad is the precursor organ to both the ovary and testis and develops as part of the embryonic urogenital system. In mice, gonadogenesis initiates around embryonic day 9.5 (E9.5), when coelomic epithelial (CE) cells overla…
View article: Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary
Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in <i>Trachemys scripta</i>
Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in <i>Trachemys scripta</i> Open
In species with genetic sex determination (GSD), the sex identity of the soma determines germ cell fate. For example, in mice, XY germ cells that enter an ovary differentiate as oogonia, whereas XX germ cells that enter a testis initiate d…
View article: Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary
Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary
Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: Reviewer #1 (Public Review): Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary
Reviewer #1 (Public Review): Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray's Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: Reviewer #3 (Public Review): Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary
Reviewer #3 (Public Review): Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray's Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: OoCount: A Machine-Learning Based Approach to Mouse Ovarian Follicle Counting and Classification
OoCount: A Machine-Learning Based Approach to Mouse Ovarian Follicle Counting and Classification Open
The number and distribution of ovarian follicles in each growth stage provides a reliable readout of ovarian health and function. Leveraging techniques for three-dimensional (3D) imaging of ovaries in toto has the potential to uncover tota…
View article: Rediscovering the <i>Rete Ovarii</i> : a secreting auxiliary structure to the ovary
Rediscovering the <i>Rete Ovarii</i> : a secreting auxiliary structure to the ovary Open
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a…
View article: Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues
Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues Open
The rete ovarii (RO) is an epithelial structure that arises during fetal development in close proximity to the ovary and persists throughout adulthood in mice. However, the functional significance of the RO remains elusive, and it has been…
View article: Testis morphogenesis and fetal Leydig cell development are mediated through ERK signaling activated by platelet derived growth factor receptor alpha
Testis morphogenesis and fetal Leydig cell development are mediated through ERK signaling activated by platelet derived growth factor receptor alpha Open
Platelet derived growth factor receptor alpha ( Pdgfra ) plays a crucial role in the morphogenesis and differentiation of the fetal testis, but the molecular signaling involved in these processes remains unclear. Here, we use XY Pdgfra -nu…
View article: Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice
Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice Open
Testicular teratomas and teratocarcinomas are the most common testicular germ cell tumors in early childhood and young men, and they are frequently found unilaterally in the left testis. In 129/SvJ mice carrying a heterozygous copy of the …
View article: Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse
Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse Open
During mammalian development, gonadal sex determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cell fates. Typically, this decision is coordinated across the gonad to ensure commitment to a sing…
View article: The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation
The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation Open
DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional …
View article: Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis
Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis Open
Mammalian sex is determined by opposing networks of ovarian and testicular genes that are well characterized. However, its epigenetic regulation is still largely unknown, thus limiting our understanding of a fundamental process for species…
View article: Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii
Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii Open
Morphogenetic events during the development of the fetal ovary are crucial to the establishment of female fertility. However, the effects of structural rearrangements of the ovary and surrounding reproductive tissues on ovary morphogenesis…
View article: Author response: Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii
Author response: Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Morphogen…
View article: Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad
Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad Open
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origi…
View article: Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad
Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad Open
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origi…
View article: A brief review of vertebrate sex evolution with a pledge for integrative research: towards ‘ <i>sexomics</i> ’
A brief review of vertebrate sex evolution with a pledge for integrative research: towards ‘ <i>sexomics</i> ’ Open
Triggers and biological processes controlling male or female gonadal differentiation vary in vertebrates, with sex determination (SD) governed by environmental factors or simple to complex genetic mechanisms that evolved repeatedly and ind…
View article: Sex determination without sex chromosomes
Sex determination without sex chromosomes Open
With or without sex chromosomes, sex determination is a synthesis of many molecular events that drives a community of cells towards a coordinated tissue fate. In this review, we will consider how a sex determination pathway can be engaged …
View article: Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii
Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii Open
Morphogenetic events during development of the fetal ovary are crucial to the establishment of female fertility. However, the effects of structural rearrangements of the ovary and surrounding reproductive tissues on ovary morphogenesis rem…
View article: Loss of <i>Mafb</i> and <i>Maf</i> distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†
Loss of <i>Mafb</i> and <i>Maf</i> distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis† Open
Testis differentiation is initiated when Sry in pre-Sertoli cells directs the gonad toward a male-specific fate. Sertoli cells are essential for testis development, but cell types within the interstitial compartment, such as immune and end…
View article: Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography
Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography Open
Objective. The peripheral nervous system (PNS) connects the central nervous system with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestina…
View article: Loss of<i>Mafb</i>and<i>Maf</i>distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis
Loss of<i>Mafb</i>and<i>Maf</i>distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis Open
Testis differentiation is initiated when Sry in pre-Sertoli cells directs the gonad toward a male-specific fate. Sertoli cells are essential for testis development, but cell types within the interstitial compartment, such as immune and end…