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View article: Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups Open
Introduction While complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs …
View article: Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study
Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study Open
Background Dysregulation of complement system is thought to be a major player in development of multi-organ damage and adverse outcomes in patients with coronavirus disease 2019 (COVID-19). This study aimed to examine associations between …
View article: Associations between the von Willebrand Factor—ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality
Associations between the von Willebrand Factor—ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality Open
Background Endothelial and complement activation were both associated with immunothrombosis, a key determinant of COVID-19 severity, but their interrelation has not yet been investigated. Objectives We aimed to determine von Willebrand fac…
View article: Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection
Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection Open
Objectives Uncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized t…
View article: Az allogén vérképző őssejtátültetés korai szövődményei gyermekkorban
Az allogén vérképző őssejtátültetés korai szövődményei gyermekkorban Open
Absztrakt: Bevezetés: Az allogén vérképző őssejt-transzplantáció (tx) indikációja gyermekkorban a magas szövődményráta és a nem elhanyagolható halálozás miatt csak az életet veszélyeztető betegségekre korlátozódik. A csökkentett toxicitású…
View article: Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation
Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation Open
Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is a multifactorial complication. Complement dysregulation may play an important role in the pathogenesis of TA-TMA. Our previous observations su…
View article: High-activity Classical and Alternative Complement Pathway Genotypes—Association With Donor-specific Antibody-triggered Injury and Renal Allograft Survival
High-activity Classical and Alternative Complement Pathway Genotypes—Association With Donor-specific Antibody-triggered Injury and Renal Allograft Survival Open
Background. Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical pathway and alternative pathway (AP) relates to the pathogenicity of DSA.…
View article: Complement Markers in Blood and Urine: No Diagnostic Value in Late Silent Antibody-Mediated Rejection
Complement Markers in Blood and Urine: No Diagnostic Value in Late Silent Antibody-Mediated Rejection Open
Background. Antibody-mediated rejection (AMR) is a major cause of kidney allograft failure. Its molecular mechanisms are multifaceted and may include a role of complement activation via the classical pathway. Here, we investigated whether …