Aobo Zhang
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View article: Constructing anoikis-related signatures in glioma and identifying PLAU as a new prognostic biomarker
Constructing anoikis-related signatures in glioma and identifying PLAU as a new prognostic biomarker Open
The study we conducted establishes the groundwork for comprehending the function of anoikis genes in glioma, and recognizes PLAU as a potential biomarker for glioma.
View article: Biomechanical comparison between custom-made enhanced triflange and quadri-flange acetabular components for the treatment of Paprosky IIIB acetabular bone defects
Biomechanical comparison between custom-made enhanced triflange and quadri-flange acetabular components for the treatment of Paprosky IIIB acetabular bone defects Open
Aims The management of Paprosky IIIB acetabular bone defect is challenging in revision total hip arthroplasty. Custom-made acetabular components (CMAC) have been increasingly used in recent years. However, the iliac fixed flange of CMAC is…
View article: Can Real‐World Data From Hospital Information Systems Be Directly Utilized for Efficacy Studies: An Analysis of Data Time Points
Can Real‐World Data From Hospital Information Systems Be Directly Utilized for Efficacy Studies: An Analysis of Data Time Points Open
Background Data from Hospital Information Systems are crucial components of real‐world data, but concerns arise regarding the transparency of measurement time‐points when directly utilizing for efficacy studies. The objective of the study …
View article: ROS-responsive 3D biological scaffold delivers hypoxia-primed extracellular vesicles for targeted modulation of neuroinflammation in intracerebral hemorrhage
ROS-responsive 3D biological scaffold delivers hypoxia-primed extracellular vesicles for targeted modulation of neuroinflammation in intracerebral hemorrhage Open
The ROS-responsive 3D biological scaffold -mediated delivery of Hypo-Exos modulates neuroinflammation through ubiquitination pathways, stabilizes the early-phase ICH microenvironment, and improves functional recovery. This platform represe…
View article: Effects of transcranial direct current stimulation on neuro electrical activity in mice with migraine
Effects of transcranial direct current stimulation on neuro electrical activity in mice with migraine Open
Background Although transcranial direct current stimulation (tDCS) has demonstrated clinical efficacy in alleviating migraine symptoms, the neurophysiological mechanisms underlying its modulation of cortical excitability and restoration of…
View article: Impact of factors on treatment outcomes in cervical degenerative disc disease: a logistic regression analysis of anterior decompression and interbody fusion with BAK/C technique
Impact of factors on treatment outcomes in cervical degenerative disc disease: a logistic regression analysis of anterior decompression and interbody fusion with BAK/C technique Open
Objectives To identify predictive prognostic factors through logistic regression analysis in patients with cervical degenerative disc disease (CDDD) undergoing anterior cervical discectomy and fusion (ACDF) combined with the Bagby and Kusl…
View article: Characteristics and controlling factors of the Triassic Xu5 tight sandstone reservoirs, Western Sichuan depression, China
Characteristics and controlling factors of the Triassic Xu5 tight sandstone reservoirs, Western Sichuan depression, China Open
The fifth member of the Xujiahe Formation in the West Sichuan depression of the Sichuan Basin has developed high-quality source rocks and large-scale delta distributary channel sediments, which have good potential for hydrocarbon accumulat…
View article: Combining spectral and texture indexes predicts plant diversity in temperate riverine wetlands of the lower Yellow River, China
Combining spectral and texture indexes predicts plant diversity in temperate riverine wetlands of the lower Yellow River, China Open
Remote sensing technology offers a cost-effective and efficient solution for the large-scale monitoring of wetland plant diversity. This study introduces a methodological framework that integrates spectral and texture indexes for predictin…
View article: Effects of 3D-printed exosome-functionalized brain acellular matrix hydrogel on neuroinflammation in rats following cerebral hemorrhage
Effects of 3D-printed exosome-functionalized brain acellular matrix hydrogel on neuroinflammation in rats following cerebral hemorrhage Open
The findings demonstrate that the 3D biological scaffold dECM@exo effectively maintains microenvironmental homeostasis in the early stages of ICH and improves outcomes associated with the condition. dECM@exo is poised to serve as a robust …
View article: Role of Hydrogen Transfer in Functional Molecular Materials and Devices
Role of Hydrogen Transfer in Functional Molecular Materials and Devices Open
Hydrogen transfer is a fundamental chemical process critical to the design and application of organic molecules and functional devices. By uncovering the dynamic interactions between atoms within molecules, hydrogen transfer research offer…
View article: Cysteine‑ and glycine‑rich protein 2: A vital regulator that inhibits necroptosis glioma cell by activating the JAK‑STAT1 pathways
Cysteine‑ and glycine‑rich protein 2: A vital regulator that inhibits necroptosis glioma cell by activating the JAK‑STAT1 pathways Open
Cysteine‑ and glycine‑rich protein 2 (CSRP2) are closely associated with tumor invasion and metastasis. CSRP2 is significantly upregulated in glioma tissues and is associated with the clinical stage of the tumor. Overexpression of CSRP2 in…
View article: Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization
Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization Open
Bionically designed gradient microporous scaffolds have garnered considerable attention in orthopedics and bone tissue engineering for their ability to replicate the gradual pore transition from cortical to trabecular bone, thereby integra…
View article: Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation
Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation Open
With the ongoing development of osteoimmunology, increasing evidence indicates that the local immune microenvironment plays a critical role in various stages of bone formation. Consequently, modulating the immune inflammatory response trig…
View article: Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures
Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures Open
In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variation (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microd…
View article: The prevalence, diagnostic accuracy and genotype-phenotype correlation of GNAS mutations in fibrous dysplasia: a meta-analysis
The prevalence, diagnostic accuracy and genotype-phenotype correlation of GNAS mutations in fibrous dysplasia: a meta-analysis Open
Background There is inconsistent evidence regarding the accuracy of GNAS mutations identification for the diagnosis of FD/MAS. This study was performed to estimate the prevalence and diagnostic accuracy of GNAS mutations detection and to p…
View article: From clinic to lab: Advances in porous titanium-based orthopedic implant research
From clinic to lab: Advances in porous titanium-based orthopedic implant research Open
Solid titanium alloys are extensively employed in orthopedic applications due to their reliable mechanical strength, but the stress shielding phenomenon caused by its high elastic modulus and the disadvantage of lack of bone integration ma…
View article: Influence of ferroptosis indicators on the stability of atherosclerotic plaque
Influence of ferroptosis indicators on the stability of atherosclerotic plaque Open
Ferroptosis is a new form of cell death that is unique and closely related to iron concentration, and reactive oxygen species (ROS) production. We investigated the indicators of ferroptosis between vulnerable plaque and stable plaque in at…
View article: An association between ATP7B expression and human cancer prognosis and immunotherapy: a pan-cancer perspective
An association between ATP7B expression and human cancer prognosis and immunotherapy: a pan-cancer perspective Open
Background ATP7B is a copper-transporting protein that contributes to the chemo-resistance of human cancer cells. It remains unclear what the molecular mechanisms behind ATP7B are in cancer, as well as its role in human pan-cancer studies.…
View article: Recent advancement in vascularized tissue-engineered bone based on materials design and modification
Recent advancement in vascularized tissue-engineered bone based on materials design and modification Open
Bone is one of the most vascular network-rich tissues in the body and the vascular system is essential for the development, homeostasis, and regeneration of bone. When segmental irreversible damage occurs to the bone, restoring its vascula…
View article: Biomechanical evaluation of a novel individualized zero-profile cage for anterior cervical discectomy and fusion: a finite element analysis
Biomechanical evaluation of a novel individualized zero-profile cage for anterior cervical discectomy and fusion: a finite element analysis Open
Introduction: Anterior cervical discectomy and fusion (ACDF) is a standard procedure for treating symptomatic cervical degenerative disease. The cage and plate constructs (CPCs) are widely employed in ACDF to maintain spinal stability and …