Bo Nilson
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View article: Temporal dynamics and interrelations of cytokines, neutrophil proteins, exudation, and bacterial colonization in epidermal wound healing
Temporal dynamics and interrelations of cytokines, neutrophil proteins, exudation, and bacterial colonization in epidermal wound healing Open
Introduction Inflammation is integral to wound healing; yet, its dynamics in normally healing epidermal wounds are not fully characterized. To this end, we analyzed longitudinal wound fluid samples collected from epidermal suction blister …
View article: Creation and validation of improved MALDI-TOF MS libraries for S. bovis-S. equinus-complex subspecies identification adapted to diagnostic culturing and extraction conditions
Creation and validation of improved MALDI-TOF MS libraries for S. bovis-S. equinus-complex subspecies identification adapted to diagnostic culturing and extraction conditions Open
The novel SBSEC-CMRS-BAE library performed excellently and improved MALDI-TOF MS performance in identifying SBSEC subspecies. It can be implemented directly into routine clinical practice where the Bruker MALDI Biotyper is used.
View article: Efficient Absorbance-Based Assay for Rapid Antibiotic Susceptibility Testing of Enterobacterales
Efficient Absorbance-Based Assay for Rapid Antibiotic Susceptibility Testing of Enterobacterales Open
It is increasingly important to rapidly receive information on the antimicrobial susceptibility of bacteria due to the rise in antimicrobial resistance worldwide. However, traditional phenotypic methods are time-consuming. Thus, the object…
View article: Risk of infective endocarditis and complicated infection in Staphylococcus aureus bacteremia – a retrospective cohort study on the role of bacteriuria
Risk of infective endocarditis and complicated infection in Staphylococcus aureus bacteremia – a retrospective cohort study on the role of bacteriuria Open
Purpose S. aureus bacteremia (SAB) is a common and severe infection with high mortality and morbidity. The clinical relevance of the finding of concurrent S. aureus bacteriuria (SABU) is debated. The goal of this study was to analyze wheth…
View article: Eubacterium bacteremia – a retrospective observational study of a seldom found anaerobic pathogen
Eubacterium bacteremia – a retrospective observational study of a seldom found anaerobic pathogen Open
Invasive infections with Eubacterium have a low incidence. The condition has a low mortality and an abdominal focus of infection, and malignancy, is common.
View article: The first report of Staphylococcus argenteus endocarditis with visualized valve vegetations
The first report of Staphylococcus argenteus endocarditis with visualized valve vegetations Open
Staphylococcus argenteus was recently defined as a species and has previously often been mistaken for Staphylococcus aureus due to the difficulties of conventional laboratory methods to distinguish the two species. The clinical presentatio…
View article: Temporal Dynamics and Interrelations of Cytokines, Neutrophil Proteins, Exudation, and Bacterial Colonization in Epidermal Wound Healing
Temporal Dynamics and Interrelations of Cytokines, Neutrophil Proteins, Exudation, and Bacterial Colonization in Epidermal Wound Healing Open
Inflammation is integral to wound healing, yet its dynamics in normally healing epidermal wounds are not fully characterized. To this end, we analyzed longitudinal wound fluid samples collected from epidermal suction blister wounds in heal…
View article: Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset
Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset Open
Dataset for "Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing". Data were generated from samples collected to a biobank from suction blister wounds at variou…
View article: Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset
Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset Open
Dataset for "Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing". Data were generated from samples collected to a biobank from suction blister wounds at variou…
View article: Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies Open
Aortic valve degeneration (AVD) is a life-threatening condition that has no medical treatment and lacks individual therapies. Although extensively studied with standard approaches, aetiologies behind AVD are unclear. We compared abundances…
View article: Improved identification of Streptococcus bovis-Streptococcus equinus-complex species and subspecies by MALDI-TOF MS using a novel library
Improved identification of Streptococcus bovis-Streptococcus equinus-complex species and subspecies by MALDI-TOF MS using a novel library Open
The SBSEC-CMRS library showed sufficient diagnostic accuracy, and can be implemented in clinical practice for SBSEC species and subspecies identification.
View article: Time to positivity of blood cultures in bloodstream infections with <i>Streptococcus dysgalactiae</i> and association with outcome
Time to positivity of blood cultures in bloodstream infections with <i>Streptococcus dysgalactiae</i> and association with outcome Open
TTP may be an important prognostic indicator for 30-day mortality in patients with bloodstream infections due to S. dysgalactiae.
View article: Platelet Activation and Aggregation Induced by Streptococcus bovis <i>/</i> Streptococcus equinus Complex
Platelet Activation and Aggregation Induced by Streptococcus bovis <i>/</i> Streptococcus equinus Complex Open
The capacity of bacteria to activate and aggregate platelets is believed to contribute to the pathogenesis of IE. The Streptococcus bovis / Streptococcus equinus complex (SBSEC) contains known IE-pathogens, but there is limited research on…
View article: Bacteraemia and infective endocarditis with<i>Streptococcus bovis-Streptococcus equinus-</i>complex: a retrospective cohort study
Bacteraemia and infective endocarditis with<i>Streptococcus bovis-Streptococcus equinus-</i>complex: a retrospective cohort study Open
The proportion of IE in SBSEC-bacteraemia varies substantially depending on subspecies. Echocardiography should always be considered in bacteraemia with Sg gallolyticus and Si infantarius, and can sometimes be omitted in bacteraemia with S…
View article: Enterococcus faecalis bacteremia, cardiac implantable electronic device, extraction, and the risk of recurrence
Enterococcus faecalis bacteremia, cardiac implantable electronic device, extraction, and the risk of recurrence Open
Purpose In all patients with cardiac implantable electronic devices (CIED) and Enterococcus faecalis bacteremia (EfsB), endocarditis (IE) and CIED infection should be suspected. Guidelines recommend extraction of the CIED when CIED infecti…
View article: Treatment Strategies and Risk of Recurrence in Patients With Heart Valve Prosthesis, <i>Staphylococcus aureus</i> Bacteremia, and Possible Endocarditis—A Retrospective Cohort Study
Treatment Strategies and Risk of Recurrence in Patients With Heart Valve Prosthesis, <i>Staphylococcus aureus</i> Bacteremia, and Possible Endocarditis—A Retrospective Cohort Study Open
Patients with heart valve prosthesis (HVP) and Staphylococcus aureus bacteremia (SAB) are at risk for endocarditis. In this retrospective, population-based cohort study of 134 patients with SAB and HVP, 97 patients (72%) were diagnosed wit…
View article: Time to Blood Culture Positivity: An Independent Predictor of Mortality in <i>Streptococcus Pyogenes</i> Bacteremia
Time to Blood Culture Positivity: An Independent Predictor of Mortality in <i>Streptococcus Pyogenes</i> Bacteremia Open
Background Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the associatio…
View article: Rapid and Cost-Efficient Screening of Bacterial Antibiotic Susceptibility in Enterobacteriaceae – An Assay Measured by Absorbance
Rapid and Cost-Efficient Screening of Bacterial Antibiotic Susceptibility in Enterobacteriaceae – An Assay Measured by Absorbance Open
Objectives: Due to the rise in antimicrobial resistance worldwide, it is becoming increasingly important to rapidly receive information on the antimicrobial susceptibility of isolated bacteria. Traditional phenotypic methods are slow but r…
View article: Rapid and cost-efficient screening of bacterial antibiotic susceptibility in Enterobacteriaceae – an assay measured by absorbance
Rapid and cost-efficient screening of bacterial antibiotic susceptibility in Enterobacteriaceae – an assay measured by absorbance Open
Objectives Due to the rise in antimicrobial resistance worldwide, it is becoming increasingly important to rapidly receive information on the antimicrobial susceptibility of isolated bacteria. Traditional phenotypic methods are slow but re…
View article: <i>Streptococcus bovis</i>-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
<i>Streptococcus bovis</i>-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study Open
This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based ret…
View article: Evaluation of the Forsvall biopsy needle in an<i>ex vivo</i>model of transrectal prostate biopsy – a novel needle design with the objective to reduce the risk of post-biopsy infection
Evaluation of the Forsvall biopsy needle in an<i>ex vivo</i>model of transrectal prostate biopsy – a novel needle design with the objective to reduce the risk of post-biopsy infection Open
The Forsvall needle significantly reduces colonic bacterial translocation, suggesting that it could reduce infectious complications in prostate biopsy. A clinical trial has been initiated.
View article: Time to blood culture positivity in Staphylococcus aureus bacteraemia to determine risk of infective endocarditis
Time to blood culture positivity in Staphylococcus aureus bacteraemia to determine risk of infective endocarditis Open
TTP, either by itself or as part of the POSITIVE score, can be used to identify patients with SAB at low risk for IE. Further validation is needed because TTP is sensitive to several external factors.
View article: Epidemiology, bacteriology, and clinical characteristics of HACEK bacteremia and endocarditis: a population-based retrospective study
Epidemiology, bacteriology, and clinical characteristics of HACEK bacteremia and endocarditis: a population-based retrospective study Open
The objective was to describe the epidemiology, bacteriology, clinical presentation, risk factors for endocarditis (IE), diagnostic workup, and outcome of patients with bacteremia caused by the non- influenzae Haemophilus , Aggregatibacter…