Bo Zhang
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View article: The <i>Porphyromonas gingivalis</i> lipid A 1-phosphatase LpxE requires a functional type IX secretion system for its activity
The <i>Porphyromonas gingivalis</i> lipid A 1-phosphatase LpxE requires a functional type IX secretion system for its activity Open
View article: Cilia.io: Computer vision and machine learning reveal spatial patterns of cilia beating dynamics in the spinal cord
Cilia.io: Computer vision and machine learning reveal spatial patterns of cilia beating dynamics in the spinal cord Open
Motile cilia coordinate fluid flows that are essential for normal tissue physiology and function. Cilia display diverse beating waveforms, and while pronounced defects are strongly associated with motile ciliopathies, more subtle alteratio…
View article: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors Open
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterize the prevalence and biological significance of germline P…
View article: Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer
Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer Open
View article: Structure and analysis of a virulent chitinase from Listeria monocytogenes
Structure and analysis of a virulent chitinase from Listeria monocytogenes Open
Listeria monocytogenes is the causative agent of Listeriosis, a serious foodborne illness that primarily affects pregnant women, new-borns, the elderly, and immunocompromised individuals. L. monocytogenes secretes proteins that bind and de…
View article: Cross-tissue molecular responses in the liver and blood after toxicant exposures
Cross-tissue molecular responses in the liver and blood after toxicant exposures Open
Exposure to toxic substances, particularly early in life, can perturb epigenomic marks linked to disease susceptibility. Human studies of environmental exposures often rely on surrogate tissues such as blood, but toxicant accumulation diff…
View article: Quantitative glycoproteomics identifies target N-glycoproteins of the Golgi-class I α-mannosidase SlMNSI1 that is important for tomato fruit development
Quantitative glycoproteomics identifies target N-glycoproteins of the Golgi-class I α-mannosidase SlMNSI1 that is important for tomato fruit development Open
Protein N-glycosylation is a fundamental post-translational modification, yet its role in regulating fruit development remains poorly understood. Here, we investigated the function of the class I α-mannosidase SlMNSI1 in tomato (Solanum ly…
View article: Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental Exposures
Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental Exposures Open
View article: AZD5153 enhances the chemo-sensitivity of gemcitabine on pancreatic cancer cells in vitro and in vivo
AZD5153 enhances the chemo-sensitivity of gemcitabine on pancreatic cancer cells in vitro and in vivo Open
Background Pancreatic cancer is a malignant disease with a poor prognosis. Gemcitabine (GEM), the first-line treatment drug, shows limited efficacy because of the notorious drug resistance of pancreatic cancer. Therefore, the development o…
View article: Toxicogenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource
Toxicogenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource Open
View article: Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource
Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource Open
Environmental exposures to toxic chemicals can profoundly alter the transcriptome and epigenome in both humans and animals, contributing to disease development across the lifespan. To elucidate how early-life exposure to toxicants exerts s…
View article: ToxiTaRGET: a multi-omics resource for toxicant-responsive molecular targets
ToxiTaRGET: a multi-omics resource for toxicant-responsive molecular targets Open
Environmental toxicant exposures can induce widespread alterations in both the transcriptome and epigenome of mammals, and directly contribute to the increased risk of various diseases, including cardiovascular disorders, cancer, and neuro…
View article: Validation of the Longitudinal Effect of an Integrated Nursing Intervention Based on the Integrated Theory of Health Behavior Change (ITHBC) on Multidimensional Health Indicators in Older Radiotherapy Patients
Validation of the Longitudinal Effect of an Integrated Nursing Intervention Based on the Integrated Theory of Health Behavior Change (ITHBC) on Multidimensional Health Indicators in Older Radiotherapy Patients Open
These findings confirm the efficacy of the ITHBC-based nursing model in enhancing cognitive, behavioral, and psychosocial outcomes in older patients undergoing radiotherapy. Structuring geriatric oncology care around behavioral theories, s…
View article: A comprehensive data repository of environmental toxicants exposed mouse epigenomes from the TaRGET II Consortium
A comprehensive data repository of environmental toxicants exposed mouse epigenomes from the TaRGET II Consortium Open
The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) is a multiphase program that aims to understand how environmental factors contribute to disease susceptibility using toxicant-exposed mouse…
View article: The impact of environmental exposures on the epigenomic and transcriptomic landscape of transposable elements
The impact of environmental exposures on the epigenomic and transcriptomic landscape of transposable elements Open
Transposable elements (TEs) are mobile DNA sequences that constitute a significant portion of mammalian genomes. While typically silenced by epigenetic mechanisms, mounting evidence indicates TEs can regulate gene expression and chromatin …
View article: Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective Behaviors
Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective Behaviors Open
Visceral pain and its affective component associated with cystitis remain poorly understood. Here, we delineate the role of central amygdala (CeA) neuronal ensembles in encoding and modulating cystitis-induced bladder pain and its affectiv…
View article: Erratum for Adams et al., “ <i>Legionella pneumophila</i> type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing”
Erratum for Adams et al., “ <i>Legionella pneumophila</i> type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing” Open
View article: Identification of risk factors for the progression of age-related macular degeneration: a systematic review and meta-analysis of cohort studies
Identification of risk factors for the progression of age-related macular degeneration: a systematic review and meta-analysis of cohort studies Open
Background Age-related macular degeneration (AMD) is a retinal degenerative disease that primarily affects the elderly population and is a leading cause of vision loss in older adults. There is a lack of research comprehensively examining …
View article: Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats <i>via</i> the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia
Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats <i>via</i> the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia Open
BACKGROUND While acute exposure to high-altitude hypoxic environments can lead to increased thrombosis risk, preventive measures are currently limited. Recently, human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation has been…
View article: <i>Legionella pneumophila</i> type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing
<i>Legionella pneumophila</i> type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing Open
Prior analyses suggested that the type II secretion system (T2SS) of Legionella pneumophila secretes ≥47 proteins beyond its 26 known substrates. Upon examination of mutants of wild-type strain 130b that lack those exoproteins most conserv…
View article: Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice
Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice Open
Fractures heal by rapid formation of mineralized callus. Essential to this process is proliferation of periosteal cells to supply bone-forming osteoblasts. To better understand the role of cell proliferation in fracture healing, we asked: …
View article: Quantification of single cell-type-specific alternative transcript initiation
Quantification of single cell-type-specific alternative transcript initiation Open
Cells can transcribe different isoforms of a gene by using distinct Transcriptional Start Regions (TSRs), which are recognized by RNA-Polymerase II and regulated by cell-type-specific expressed transcription factors, eventually forming tis…
View article: Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects
Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects Open
The treatment of large bone defects remains a significant clinical challenge due to the limitations of current grafting techniques, including donor site morbidity, restricted availability, and suboptimal integration. Recent advances in 3D …
View article: Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain Open
Obesity is a risk factor for osteoarthritis (OA), and leptin is among the adipokines implicated in obesity-induced OA. However, the specific role of leptin in OA severity and pain is not known. Using lipodystrophic (LD) mice, we show that …
View article: Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories
Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories Open
To understand how early-life environmental exposures shape health and disease risk across the lifecourse, the TaRGET II Consortium exposed mice to diverse toxicants from pre-conception through weaning, and followed individual animals into …
View article: Optimizing the mouse orthotopic liver transplantation model: Learning curve, technical enhancements, and keys to success
Optimizing the mouse orthotopic liver transplantation model: Learning curve, technical enhancements, and keys to success Open
Due to the easier availability of transgenic mice and reagents, the mouse orthotopic liver transplantation model offers significant advantages in liver transplantation research. However, technical challenges have limited its broader applic…
View article: Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion
Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion Open
Background Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced hindlimb angiogenesis and tissue recovery. We hypot…
View article: Bone anchoring annular suture technique for repairing annular defects at vertebral body edge following lumbar discectomy
Bone anchoring annular suture technique for repairing annular defects at vertebral body edge following lumbar discectomy Open
View article: [The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit].
[The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit]. Open
Objective: To investigate the value of Sequential Organ Failure (SOFA) score and its dynamics (ΔSOFA) in predicting mortality in hematology care unit (HCU) . Methods: A retrospective clinical study was conducted on 79 critica…
View article: OSMR Coordinates a Self-Perpetuating Circuit Linking Chemoresistance and Neutrophil-Driven Immunosuppression in Gastric Cancer
OSMR Coordinates a Self-Perpetuating Circuit Linking Chemoresistance and Neutrophil-Driven Immunosuppression in Gastric Cancer Open