Boyang Yu
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View article: Houttuynia cordata traditional extract regulates uric acid transporter and reduces xanthine oxidase activity in hyperuricemic mice
Houttuynia cordata traditional extract regulates uric acid transporter and reduces xanthine oxidase activity in hyperuricemic mice Open
View article: HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection
HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection Open
Viral protein U (Vpu), an accessory protein of HIV-1, functions by antagonizing or hijacking various host factors to allow the virus to evade host immune surveillance and facilitate viral release. Nevertheless, there is limited understandi…
View article: Artificial intelligence in acupuncture: bridging traditional knowledge and precision integrative medicine
Artificial intelligence in acupuncture: bridging traditional knowledge and precision integrative medicine Open
The integration of artificial intelligence (AI) into acupuncture research is accelerating the transformation of this traditional, experience-based practice into a data-driven, precision discipline. This review synthesizes recent advances i…
View article: Assisted Isolation of Camelliagenin B from Camellia oliefera Seed Cake Meal and Microbial Transformation by Bacillus subtilis ATCC 6633, Bacillus megaterium CGMCC 1.1741, and Streptomyces gresius ATCC 13273
Assisted Isolation of Camelliagenin B from Camellia oliefera Seed Cake Meal and Microbial Transformation by Bacillus subtilis ATCC 6633, Bacillus megaterium CGMCC 1.1741, and Streptomyces gresius ATCC 13273 Open
This study investigates the potential for the microbial transformation of camelliagenin B, a saponin derived from Camellia oleifera seed cake meal, to develop novel metabolites. We employed three microbial strains, specifically Bacillus su…
View article: Salvianolic acid A ameliorates sepsis through inhibiting inflammation via binding STING and modulating TBK1/IRF3 signaling pathway
Salvianolic acid A ameliorates sepsis through inhibiting inflammation via binding STING and modulating TBK1/IRF3 signaling pathway Open
Sepsis is a condition characterized by a systemic inflammatory response due to infection, resulting in numerous organ dysfunction. Salvianolic acid A (SAA) is a phenolic acid substance extracted from the plant Salvia miltiorrhiza Bunge, po…
View article: Heterointerface‐Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity
Heterointerface‐Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity Open
An asymmetric dual‐gate heterointerface‐regulated artificial synapse (HRAS) is developed, utilizing a main gate with distinct ion concentrations and a lateral gate to receive synaptic pulses, and through dielectric coupling and ionic effec…
View article: Research progress on the anti-aging effects and mechanisms of polysaccharides from Chinese herbal medicine
Research progress on the anti-aging effects and mechanisms of polysaccharides from Chinese herbal medicine Open
View article: Supplements extracted from <i>Lophatherum gracile</i> Brongn. ameliorates hyperuricemia by regulating nucleotide metabolic enzymes and urate transporters
Supplements extracted from <i>Lophatherum gracile</i> Brongn. ameliorates hyperuricemia by regulating nucleotide metabolic enzymes and urate transporters Open
View article: Research on the Path and Strategy of Traditional Chinese Medicine Talent Cultivation Based on Demand Orientation
Research on the Path and Strategy of Traditional Chinese Medicine Talent Cultivation Based on Demand Orientation Open
View article: A Label-Free Colorimetric Aptasensor for Flavokavain B Detection
A Label-Free Colorimetric Aptasensor for Flavokavain B Detection Open
Flavokavain B (FKB), a hepatotoxic chalcone from Piper methysticum (kava), has raised safety concerns due to its role in disrupting redox homeostasis and inducing apoptosis in hepatocytes. Conventional chromatographic methods for FKB detec…
View article: Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells
Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells Open
Ovarian tissue cryopreservation addresses critical challenges in fertility preservation for prepubertal female cancer patients, such as the lack of viable eggs and hormonal deficiencies. However, mitigating follicle and granulosa cell dama…
View article: Microbial Transformation of Soyasapogenol C and Potential of its Metabolites Against Hmgb1 and Lps-Triggered Inflammation
Microbial Transformation of Soyasapogenol C and Potential of its Metabolites Against Hmgb1 and Lps-Triggered Inflammation Open
View article: Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage
Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage Open
The findings indicated that NMMHC IIA dissociated from PAR1 and activated CREB3/ARF4 pathway, which aggravated BBB damage induced by thrombin. This suggested that NMMHC IIA was a novel potential therapeutic target for BBB-related diseases.
View article: Equity evaluation of intensive care unit admission based on comorbidity in hospitalized patients with COVID-19: a cross-sectional analysis
Equity evaluation of intensive care unit admission based on comorbidity in hospitalized patients with COVID-19: a cross-sectional analysis Open
Background Intensive care unit (ICU) beds played a crucial role in reducing mortality rates of patients with severe COVID-19. The surge in the number of patients led to a shortage of ICU beds, which may have exacerbated inequity of healthc…
View article: Hunting for Monolayer Black Phosphorus with Photoluminescence Microscopy
Hunting for Monolayer Black Phosphorus with Photoluminescence Microscopy Open
Monolayer black phosphorus (BP) holds great promise for naturally hyperbolic polaritons and correlated states in rectangular moiré superlattices. However, preparing and identifying high-quality monolayer BP are challenging due to its insta…
View article: Plasmons in the Kagome metal CsV3Sb5
Plasmons in the Kagome metal CsV3Sb5 Open
Plasmon polaritons, or plasmons, are coupled oscillations of electrons and electromagnetic fields that can confine the latter into deeply subwavelength scales, enabling novel polaritonic devices. While plasmons have been extensively studie…
View article: Target Cell Extraction and Spectrum–Effect Relationship Coupled with BP Neural Network Classification for Screening Potential Bioactive Components in Ginseng Extract with a Protective Effect against Myocardial Damage
Target Cell Extraction and Spectrum–Effect Relationship Coupled with BP Neural Network Classification for Screening Potential Bioactive Components in Ginseng Extract with a Protective Effect against Myocardial Damage Open
Cardiovascular disease has become a common ailment that endangers human health, having garnered widespread attention due to its high prevalence, recurrence rate, and sudden death risk. Ginseng possesses functions such as invigorating vital…
View article: Correlation Function Of Thin-Shell Operators
Correlation Function Of Thin-Shell Operators Open
In this study, we explore the correlation functions of thin-shell operators, represented semiclassically by a homogeneous, thin interface of dust particles. Employing the monodromy method, we successfully compute the contribution from the …
View article: Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure
Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure Open
Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats ind…
View article: Probing the Interactions of Genistein with Hmgb1 Through Multi-Spectroscopic and In-Silico Approaches
Probing the Interactions of Genistein with Hmgb1 Through Multi-Spectroscopic and In-Silico Approaches Open
View article: Blockade of spinal dopamine D1/D2 receptor heteromers by <i>levo</i>-Corydalmine suppressed calcium signaling cascade in spinal neurons to alleviate bone cancer pain in rats
Blockade of spinal dopamine D1/D2 receptor heteromers by <i>levo</i>-Corydalmine suppressed calcium signaling cascade in spinal neurons to alleviate bone cancer pain in rats Open
Background: Dopamine receptors have been reported to be involved in pain, while the exact effects and mechanism in bone cancer pain have not been fully explored. Methods: Bone cancer pain model was created by implanting walke…
View article: Protection Effect of Dioscoreae Rhizoma Against Ethanol-Induced Gastric Injury in Vitro and in Vivo: A Phytochemical and Pharmacological Study
Protection Effect of Dioscoreae Rhizoma Against Ethanol-Induced Gastric Injury in Vitro and in Vivo: A Phytochemical and Pharmacological Study Open
View article: Natural triterpenoid-aided identification of the druggable interface of HMGB1 occupied by TLR4
Natural triterpenoid-aided identification of the druggable interface of HMGB1 occupied by TLR4 Open
Using the unique triterpenoid probe, we found that the binding interface of HMGB1 was responsible for the recognition of TLR4 located on the “L” shaped B-box with K114 as a crucial hot-spot residue.
View article: Stochastic gradient descent with random label noises: doubly stochastic models and inference stabilizer
Stochastic gradient descent with random label noises: doubly stochastic models and inference stabilizer Open
Random label noise (or observational noise) widely exists in practical machine learning settings. While previous studies primarily focused on the effects of label noise to the performance of learning, our work intends to investigate the im…
View article: Illumination of Hydroxyl Radical in Kidney Injury and High‐Throughput Screening of Natural Protectants Using a Fluorescent/Photoacoustic Probe (Adv. Sci. 33/2023)
Illumination of Hydroxyl Radical in Kidney Injury and High‐Throughput Screening of Natural Protectants Using a Fluorescent/Photoacoustic Probe (Adv. Sci. 33/2023) Open
Illumination of Hydroxyl Radical in Kidney Injury The ancient Chinese myth of “Nuwa Mending the Sky” narrates the tale of the revered goddess Nuwa, who skillfully used the vibrant stone to mend the celestial realm. In a parallel vein, the …
View article: Gender differences in depressive symptoms among Chinese older adults based on fairlie decomposition analysis
Gender differences in depressive symptoms among Chinese older adults based on fairlie decomposition analysis Open
This study aimed to investigate the factors influencing depressive symptoms among Chinese older adults based on gender differences. Data from the eighth wave of Chinese Longitudinal Health Longevity Survey were used. We analyzed the influe…
View article: Illumination of Hydroxyl Radical in Kidney Injury and High‐Throughput Screening of Natural Protectants Using a Fluorescent/Photoacoustic Probe
Illumination of Hydroxyl Radical in Kidney Injury and High‐Throughput Screening of Natural Protectants Using a Fluorescent/Photoacoustic Probe Open
The hydroxyl radical (•OH) is shown to play a crucial role in the occurrence and progression of acute kidney injury (AKI). Therefore, the development of a robust •OH probe holds great promise for the early diagnosis of AKI, high‐throughput…
View article: Decomposition and comparative analysis of health inequities between the male and female older adults in China: a national cross-sectional study
Decomposition and comparative analysis of health inequities between the male and female older adults in China: a national cross-sectional study Open
View article: 3D Facial Expression Generator Based on Transformer VAE
3D Facial Expression Generator Based on Transformer VAE Open
International audience
View article: Layer-dependent exciton polarizability and the brightening of dark excitons in few-layer black phosphorus
Layer-dependent exciton polarizability and the brightening of dark excitons in few-layer black phosphorus Open