Jianbo Yang
YOU?
Author Swipe
View article: Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system
Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system Open
Introduction Polygonum multiflorum Thunb. (PM) is a representative traditional Chinese medicine (TCM) that exerts different effects in raw and processed forms. The hepatotoxicity of PM is markedly reduced after processing, whereas its hepa…
View article: Development of a Radioactive Sorting and Volume Reduction System for Radioactive Contaminated Sandy Soil Using Plastic Scintillator and NaI Detectors
Development of a Radioactive Sorting and Volume Reduction System for Radioactive Contaminated Sandy Soil Using Plastic Scintillator and NaI Detectors Open
Radioactively contaminated sandy soil is commonly encountered during nuclear facility decommissioning and nuclear accident response, and its rapid sorting and volume reduction are crucial for achieving waste minimization and lowering remed…
On-line identification of chemical constituents in Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata based on UHPLC-Q-Orbitrap-Linear Ion Trap-MS Open
These findings provide a robust scientific foundation for further exploration of the active and toxic components in Polygoni Multiflori Radix and its processed form, Polygoni Multiflori Radix Preparata, contributing to a deeper understandi…
View article: Integrated Modeling of Maritime Accident Hotspots and Vessel Traffic Networks in High-Density Waterways: A Case Study of the Strait of Malacca
Integrated Modeling of Maritime Accident Hotspots and Vessel Traffic Networks in High-Density Waterways: A Case Study of the Strait of Malacca Open
The Strait of Malacca faces persistent maritime safety challenges due to high vessel density and complex navigational conditions. Current risk assessment methods often lean towards treating static accident analysis and dynamic traffic mode…
View article: Functional and Compositional Changes in Ileal Microbiota in Piglets During the Nursing Period Revealed by 16s rRNA Gene and Metagenomics
Functional and Compositional Changes in Ileal Microbiota in Piglets During the Nursing Period Revealed by 16s rRNA Gene and Metagenomics Open
In piglets, the gut microbiota matures in a segment-specific manner during the nursing period, while fecal-based studies provide limited functional resolution across intestinal sites. We profiled the ileum using 16s rRNA gene sequencing an…
View article: ANXA2 in hepatocellular carcinoma: orchestrating tumorigenesis, progression, and therapeutic resistance toward precision targeting
ANXA2 in hepatocellular carcinoma: orchestrating tumorigenesis, progression, and therapeutic resistance toward precision targeting Open
Hepatocellular carcinoma (HCC) represents a highly heterogeneous malignancy whose pathogenesis involves multiple etiological factors, including hepatitis viruses, metabolic disorders, and environmental carcinogens. Nevertheless, clinical m…
Mozart: A Chiplet Ecosystem-Accelerator Codesign Framework for Composable Bespoke Application Specific Integrated Circuits Open
Modern AI acceleration faces a fundamental challenge: conventional assumptions about memory requirements, batching effectiveness, and latency-throughput tradeoffs are systemwide generalizations that ignore the heterogeneous computational p…
View article: LiveOIBench: Can Large Language Models Outperform Human Contestants in Informatics Olympiads?
LiveOIBench: Can Large Language Models Outperform Human Contestants in Informatics Olympiads? Open
Competitive programming problems increasingly serve as valuable benchmarks to evaluate the coding capabilities of large language models (LLMs) due to their complexity and ease of verification. Yet, current coding benchmarks face limitation…
View article: Numerical Study and Design Optimization of Geometry Parameters of Tesla Valve Flow Fields for Proton Exchange Membrane Fuel Cell
Numerical Study and Design Optimization of Geometry Parameters of Tesla Valve Flow Fields for Proton Exchange Membrane Fuel Cell Open
Flow field design in proton exchange membrane fuel cells (PEMFCs) is a critical issue, as it plays an important role in governing reactant transport dynamics and cell performance. In this work, numerical studies of a single Tesla-valve flo…
View article: Biochar and Soil Water Synergistically Regulating Root Growth to Affect Photosynthesis in Maize (Zea mays L.)
Biochar and Soil Water Synergistically Regulating Root Growth to Affect Photosynthesis in Maize (Zea mays L.) Open
In arid/semi-arid regions, strategies to enhance soil water retention are critical for crop productivity. This study elucidates the synergistic regulatory mechanisms of biochar and soil water regulation on maize root growth and photosynthe…
View article: AISStream-MCP: A Real-Time Memory-Augmented Question-Answering System for Maritime Operations
AISStream-MCP: A Real-Time Memory-Augmented Question-Answering System for Maritime Operations Open
Ports and maritime operations generate massive real-time data streams, particularly from Automatic Identification System (AIS) signals, which are challenging to query effectively using natural language. This study proposes a prototype AISS…
View article: A Knowledge Graph-Driven Framework for Personalized Psychological Intervention Recommendations
A Knowledge Graph-Driven Framework for Personalized Psychological Intervention Recommendations Open
Recent advancements in knowledge graph (KGs) technology and machine learning (ML) have shown significant potential in addressing complex challenges in personalized recommendation systems. This study develops a novel framework for psycholog…
Hypersurfaces of constant sum Hessian curvature in Hyperbolic space Open
In this paper, we study the asymptotic Plateau problem in hyperbolic space for constant sum Hessian curvature. More precisely, given a asymptotic boundary $Γ$, one seeks a complete hypersurface $Σ$ in $\mathbb{H}^{n+1}$ satisfying $σ_{n-1}…
View article: Research Progress on Chemical Compositions, Pharmacological Activities, and Toxicities of Quinone Compounds in Traditional Chinese Medicines
Research Progress on Chemical Compositions, Pharmacological Activities, and Toxicities of Quinone Compounds in Traditional Chinese Medicines Open
With the continuous development of research on natural medicines, quinone compounds have become increasingly important in the research field of chemical constituents of natural treatments. However, there is a lack of in-depth and systemati…
Screening signal peptides from Bacillus thuringiensis secretome for heterologous protein secretion Open
Efficient secretion of heterologous proteins is crucial for applications in industrial and biomedical fields. Selecting appropriate signal peptides and bacterial strains is critical for successful protein expression and export. Bacillus th…
View article: In Southwestern Yunnan, China, Carbon Stock Accumulation in <em>Pinus kesiya</em> Forests Under the Grain for Green Programme
In Southwestern Yunnan, China, Carbon Stock Accumulation in <em>Pinus kesiya</em> Forests Under the Grain for Green Programme Open
Southwest China, a global biodiversity hotspot, plays a vital role in carbon sequestration and ecological restoration through its forest ecosystems. This study systematically evaluated changes in carbon stocks and their driving factors in …
View article: Traceability and Adulteration Analysis of Citri Reticulatae Pericarpium Based on “Digital Identity Card” and <scp>UHPLC</scp>‐<scp>QTOF</scp>‐<scp>MS</scp> Analysis
Traceability and Adulteration Analysis of Citri Reticulatae Pericarpium Based on “Digital Identity Card” and <span>UHPLC</span>‐<span>QTOF</span>‐<span>MS</span> Analysis Open
In order to improve the identification efficiency, strengthen quality control, and realize the quick traceability and adulteration analysis of Citri Reticulatae Pericarpium (CRP) and Xinhui's Citri Reticulatae Pericarpium (XCRP, geoauthent…
Metal and metal oxide nanoparticle-assisted molecular assays for the detection of Salmonella Open
This paper provides a comprehensive overview of the diverse applications and innovations of nanoparticles in the detection of Salmonella. It encompasses a comprehensive range of novel methods, including efficient enrichment, nucleic acid e…
LLM-ABM for Transportation: Assessing the Potential of LLM Agents in System Analysis Open
Agent-based modeling approaches represent the state-of-art in modeling travel demand and transportation system dynamics and are valuable tools for transportation planning. However, established agent-based approaches in transportation rely …
View article: Advances in porcine epidemic diarrhea virus research: genome, epidemiology, vaccines, and detection methods
Advances in porcine epidemic diarrhea virus research: genome, epidemiology, vaccines, and detection methods Open
Porcine epidemic diarrhea (PED) is a highly contagious intestinal disease caused by the porcine epidemic diarrhea virus (PEDV). The economic impact of PEDV on the global pig industry has been significant, resulting in considerable losses. …
View article: PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer
PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer Open
Cancer remains the foremost cause of mortality on a global scale. Immunotherapy has yielded remarkable outcomes in the fight against cancer and is regarded as one of the most crucial and promising therapeutic modalities. PCSK9, a critical …
View article: Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in Pleuropterus multiflorus Thunb.
Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in Pleuropterus multiflorus Thunb. Open
As a traditional Chinese medicine, the adverse hepatotoxicity effects of Pleuropterus multiflorus (Thunb.) Nakai (PM) have been documented. However, nephrotoxicity has been neglected as studies related to kidney toxicity mechanisms are lim…
View article: Two polysaccharides from Polygonum multiflorum Thunb. exert anti-aging by regulating P53/P21 pathway and amino acid metabolism
Two polysaccharides from Polygonum multiflorum Thunb. exert anti-aging by regulating P53/P21 pathway and amino acid metabolism Open
Polygonum multiflorum Thunb (PM) is known for its potential to extend lifespan. Although the polysaccharides, the primary constituents of PM, remain largely unexplored in terms of their anti-aging effects and underlying mechanisms, this st…
Advances in molecular epidemiology and detection methods of pseudorabies virus Open
Pseudorabies (PR), a highly contagious disease caused by the pseudorabies virus (PRV), represents a significant threat to the global swine industry. Despite the success of developed countries in controlling the PRV epidemic through swine p…
View article: Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer’s disease
Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatment currently available. The Panax ginseng C.A.Mey. and Polygonum multiflorum Thunb. formula (GSPM) has shown potential neuroprotective…
View article: Towards a universal foundation model for biobank-scale human genome variation
Towards a universal foundation model for biobank-scale human genome variation Open
Millions of human genomes have been genotyped by national biobanks worldwide. Training large language models (LLM) with this data may lead to a universal model of human genome with tremendous potential. Yet the quadrillions (10 15 ) of nuc…