Ying Chen
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View article: Macro-micro failure characteristics of sandstone specimens with different water contents under unloading conditions
Macro-micro failure characteristics of sandstone specimens with different water contents under unloading conditions Open
Water-contained sandstones are often encountered in tunneling projects in Southwest China, and their deformation and failure mechanisms are complicated, especially under the influence of high stress excavation unloading. In this research, …
View article: Global and regional molecular epidemiology of HIV-1 among men who have sex with men: a systematic review and meta-analysis
Global and regional molecular epidemiology of HIV-1 among men who have sex with men: a systematic review and meta-analysis Open
Global and regions MSM HIV-1 subtypes are becoming more complex over time and the prevalence of recombinant viruses is increasing. Ongoing and effective surveillance of the global and regional molecular epidemiology of HIV-1 in MSM is crit…
View article: The role of cyclic di-GMP in biomaterial-associated infections caused by commensal Escherichia coli
The role of cyclic di-GMP in biomaterial-associated infections caused by commensal Escherichia coli Open
Biofilms are protective structures that bacteria use to evade the immune system and resist antibiotics, leading to complications in medical treatments, especially with implanted devices. The molecule cyclic di-GMP (c-di-GMP) is crucial for…
View article: A latent profile analysis of cancer survivors’ return to work adaptability and the associations between its’ categories and financial toxicity
A latent profile analysis of cancer survivors’ return to work adaptability and the associations between its’ categories and financial toxicity Open
To explore potential categories of cancer survivors' return to work adaptability, analyze associated influences, and identify the associations between different categories and financial toxicity. 412 cancer survivors were selected as parti…
View article: Integrating a Multimodal Digital Device for Continuous Perioperative Monitoring in Patients With Lung Cancer Undergoing Thoracic Surgery: Development and Usability Study
Integrating a Multimodal Digital Device for Continuous Perioperative Monitoring in Patients With Lung Cancer Undergoing Thoracic Surgery: Development and Usability Study Open
Background Minimally invasive thoracic surgery has improved lung cancer outcomes but requires enhanced postoperative care. Traditionally, the episodic care model has limited timely and multidimensional monitoring of patients. Recent techno…
View article: Endoscopic ultrasound-guided fine-needle aspiration value in suspected autoimmune pancreatitis malignancy diagnosis
Endoscopic ultrasound-guided fine-needle aspiration value in suspected autoimmune pancreatitis malignancy diagnosis Open
Objective: Histopathology examination is important for diagnosing autoimmune pancreatitis (AIP), which is suspected to be pancreatic cancer based on imaging findings. Although the validity of endoscopic ultrasound-guided fine-needle aspira…
View article: NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis Open
Metastatic colorectal cancer (CRC) cells endure survival challenges, including treatment-induced ferroptosis. While adaptation to ferroptosis stress facilitates metastasis, reciprocal regulatory mechanisms remain unclear. Here, a CRISPR-Ca…
View article: Transmembrane mucins in lung adenocarcinoma: understanding of current molecular mechanisms and clinical applications
Transmembrane mucins in lung adenocarcinoma: understanding of current molecular mechanisms and clinical applications Open
The mucin family is a group of highly glycosylated macromolecules widely present in human epithelial cells and with subtypes of secreted and membrane-associated forms. The membrane-associated mucins, known as transmembrane mucins, are not …
View article: Diagnostic value of metagenomic next-generation sequencing in detecting Pneumocystis jirovecii pneumonia in HIV-infected patients
Diagnostic value of metagenomic next-generation sequencing in detecting Pneumocystis jirovecii pneumonia in HIV-infected patients Open
Introduction Accurate diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV patients remains challenging. This study compares metagenomic next-generation sequencing (mNGS) with PCR, GMS staining, and serum β-D-glucan (BG) assays for P…
View article: Combined predictive value of uric acid and serum lipid for stroke events in non-valvular atrial fibrillation patients
Combined predictive value of uric acid and serum lipid for stroke events in non-valvular atrial fibrillation patients Open
Background Serum uric acid (SUA) and lipid metabolism disorders are closely associated with atrial fibrillation (AF) and its prognosis. In patients with non-valvular AF (NAF), we evaluated the combined predictive value of SUA, triglyceride…
View article: Anthropogenic air pollutants strongly interact with natural aerosols over the eastern China seas: key processes, size distributions, and seasonalities
Anthropogenic air pollutants strongly interact with natural aerosols over the eastern China seas: key processes, size distributions, and seasonalities Open
Marine aerosols play important roles in climate, marine biogeochemistry, and coastal air quality. Over the eastern China seas adjacent to densely populated East Asia, aerosols are mutually affected by anthropogenic pollution and natural em…
View article: The prevalence and correlation of cancer-related fatigue and locomotive syndrome in geriatric cancer patients
The prevalence and correlation of cancer-related fatigue and locomotive syndrome in geriatric cancer patients Open
Objective To explore the relationship between cancer-related fatigue (CRF) and locomotive syndrome (LS) among Chinese older adults with cancer. Methods This study was a cross-sectional survey. Staged random sampling method was employed to …
View article: Reprogramming astrocytes into dopaminergic neurons to restore motor dysfunction in Parkinson<b>'</b>s disease model rats.
Reprogramming astrocytes into dopaminergic neurons to restore motor dysfunction in Parkinson<b>'</b>s disease model rats. Open
Lentiviral overexpression of NURR1 and ASCL1 efficiently reprograms AS into DA neurons. Transplantation of reprogrammed DA neurons significantly improves motor function in PD rats, highlighting their potential as donor cells for the treatm…
View article: Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress
Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress Open
Our results revealed that GTSs improved intestinal microecological disorders and impaired immune function caused by the weightlessness simulation. The underlying mechanism may be related to the "intestinal immune -microbiota-metabolic" pat…
View article: Comparative prognosis of liver transplantation versus liver resection in intrahepatic cholangiocarcinoma: a systematic review and meta-analysis
Comparative prognosis of liver transplantation versus liver resection in intrahepatic cholangiocarcinoma: a systematic review and meta-analysis Open
For patients with ICC, LT seems to have optimistic survival results under certain conditions compared with curative hepatectomy. Since LT is a potential treatment for ICC, it is currently uncertain whether LT should be more considered in p…
View article: Pigmented Skin Disorders in High‐Altitude: Cross‐Sectional Epidemiological Analysis in the General Population of Lhasa, China
Pigmented Skin Disorders in High‐Altitude: Cross‐Sectional Epidemiological Analysis in the General Population of Lhasa, China Open
Background Previous studies showed the prevalence of melasma, plateau facial telangiectasia, and vitiligo varied in different regions but were absent in high‐altitude areas. Aims To investigate the prevalence of three common pigmented skin…
View article: H3K9me3 and H3K27me3 are epigenetic barriers to somatic cell nuclear transfer in rabbits
H3K9me3 and H3K27me3 are epigenetic barriers to somatic cell nuclear transfer in rabbits Open
Somatic cell nuclear transfer (NT) is associated with aberrant changes in epigenetic reprogramming that disrupt embryo development. Here, we characterized the epigenetic patterns of histone 3 lysine 9 trimethylation (H3K9me3) and histone 3…
View article: Pulmonary Mucormycosis in an Older Acute Myeloid Leukemia Patient
Pulmonary Mucormycosis in an Older Acute Myeloid Leukemia Patient Open
Mucormycosis is a rare but fatal opportunistic fungal infection. Patients with hematologic malignancies who use immunosuppressant and glucocorticoid extensively are susceptible to mucormycosis. We report a case of an older patient with acu…
View article: The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial trauma: a randomized clinical trial
The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial trauma: a randomized clinical trial Open
The study was retrospectively registered in chictr.org.cn with the identifier: ChiCTR2400086662 on 08/07/2024.
View article: Pasteurized Akkermansia muciniphila Ameliorates Preeclampsia in Mice by Enhancing Gut Barrier Integrity, Improving Endothelial Function, and Modulating Gut Metabolic Dysregulation
Pasteurized Akkermansia muciniphila Ameliorates Preeclampsia in Mice by Enhancing Gut Barrier Integrity, Improving Endothelial Function, and Modulating Gut Metabolic Dysregulation Open
Preeclampsia (PE) is a serious complication of pregnancy linked to endothelial dysfunction and an imbalance in the gut microbiota. While Akkermansia muciniphila (AKK) has shown promise in alleviating PE symptoms, the use of live bacteria r…
View article: Two Plaquette-Singlet Phases and Emergent SO(5) Deconfined Quantum Criticality in SrCu2(BO3)2
Two Plaquette-Singlet Phases and Emergent SO(5) Deconfined Quantum Criticality in SrCu2(BO3)2 Open
The deconfined quantum critical point (DQCP) has become a central open concept in the physics of quantum matter, and its proposed presence in the Shastry-Sutherland model was followed by the experimental observation of at least a minimal D…