Paul B. Yu
YOU?
Author Swipe
View article: BMP9 regulates the endothelial secretome to drive pulmonary hypertension
BMP9 regulates the endothelial secretome to drive pulmonary hypertension Open
BMP9, a pleiotropic growth factor cytokine that regulates endothelial function, is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). Loss-of-function mutations in GDF2 are found in heritable PAH, suggesting its funct…
View article: Transpulmonary bubble transit in patients hospitalised with COVID-19 pneumonia
Transpulmonary bubble transit in patients hospitalised with COVID-19 pneumonia Open
Background We previously demonstrated a high prevalence of transpulmonary bubble transit (TPBT) using transcranial Doppler (TCD) in patients with COVID-19 pneumonia, but these observations require confirmation. Methods Patients at two acad…
View article: A physical state prediction method based on reduce order model and deep learning applied in virtual reality
A physical state prediction method based on reduce order model and deep learning applied in virtual reality Open
The application of virtual reality (VR) in industrial training and safety emergency needs to reflect realistic changes in physical object properties. However, existing VR systems still lack fast and accurate simulation of complex, high-fid…
View article: Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3 Open
View article: The prevalence and genetic characteristics of human bocavirus in patients with acute respiratory infection in China during 2012–2021
The prevalence and genetic characteristics of human bocavirus in patients with acute respiratory infection in China during 2012–2021 Open
Human bocavirus (HBoV) is a common respiratory virus among patients with acute respiratory infection (ARI). To investigate the prevalence and genetic characteristics of HBoV, clinical specimens from 13,109 ARI patients were collected throu…
View article: Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions <i>Ednrb</i> <sup>+</sup>EC and <i>Dhcr24</i> <sup>+</sup>macrophage populations
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions <i>Ednrb</i> <sup>+</sup>EC and <i>Dhcr24</i> <sup>+</sup>macrophage populations Open
Background Animal models are used widely to study pulmonary hypertension (PH). The cell populations that respond to disease-inducing stimuli in these models and their relationship to human disease remain incompletely defined. Materials and…
View article: Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection
Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection Open
View article: Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage
Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage Open
This study pioneers the application of polyoxometalates in intracerebral haemorrhage, offering a novel and promising therapeutic approach for the management of ferroptosis-related brain injuries.
View article: Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies
Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies Open
View article: Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics
Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics Open
Rationale: Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by increased pulmonary blood pressures and regional inhomogeneities in flows, with diagnostic and treatment challenges arising from divers…
View article: Genomic characteristics and genetic manipulation of the marine yeast Scheffersomyces spartinae
Genomic characteristics and genetic manipulation of the marine yeast Scheffersomyces spartinae Open
View article: Hepatopulmonary Syndrome, Another Face of Dysregulated BMP9 Signaling
Hepatopulmonary Syndrome, Another Face of Dysregulated BMP9 Signaling Open
View article: Comparing [18F]FET PET and [18F]FDOPA PET for glioma recurrence diagnosis: a systematic review and meta-analysis
Comparing [18F]FET PET and [18F]FDOPA PET for glioma recurrence diagnosis: a systematic review and meta-analysis Open
Purpose The purpose of our meta-analysis and systematic review was to evaluate and compare the diagnostic effectiveness of [18F]FET PET and [18F]FDOPA PET in detecting glioma recurrence. Methods Sensitivities and specificities were assesse…
View article: FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis—Brief Report
FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis—Brief Report Open
BACKGROUND: BETs (bromodomain and extraterminal domain–containing epigenetic reader proteins), including BRD4 (bromodomain-containing protein 4), orchestrate transcriptional programs induced by pathogenic stimuli, as intensively studied in…
View article: Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases
Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases Open
View article: Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension
Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension Open
View article: Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries
Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries Open
Utilizing mouse precision-cut lung slices with preserved intrapulmonary vessels, we demonstrated a location-dependent structural and contractile regulation of pulmonary arteries in health and on noxious stimulations. For instance, chronic …
View article: Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis
Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis Open
Aims Blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether and how eosinophils and ECP contribute to vascular calcification and atherogenesis. Meth…
View article: Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension
Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension Open
Introduction: Pulmonary arterial hypertension (PAH) is characterised by loss of microvessels. The Wnt pathways control pulmonary angiogenesis but their role in PAH is incompletely understood. We hypothesised that Wnt activation in pulmonar…
View article: The seroepidemiology of measles in Xi'an, China
The seroepidemiology of measles in Xi'an, China Open
The number of measles cases reported worldwide has increased in recent years, and in 2015, there was a measles outbreak in Xi’an, China. However, the epidemiology of measles and the seroepidemiology of healthy people after 2015 have not be…
View article: Metabolomics in the Research of Viral Infectious Disease Mechanisms
Metabolomics in the Research of Viral Infectious Disease Mechanisms Open
Viral invasion of the body causes metabolic changes involving pathways such as gluconeogenesis, amino acid metabolism, lipid metabolism, the TCA cycle, and energy metabolism and affects vital bodily processes such as nucleic acid, protein,…
View article: Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography
Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography Open
View article: GDF3 is an obesity-induced regulator of TGFβ superfamily signaling
GDF3 is an obesity-induced regulator of TGFβ superfamily signaling Open
Growth differentiation factor 3 (GDF3) is a relatively understudied member of the TGFβ superfamily that is highly expressed during development. However, the function of GDF3 in adult biology is contentious. We use in vivo approaches to sho…
View article: Decoding the Link Between Inflammation and Pulmonary Arterial Hypertension
Decoding the Link Between Inflammation and Pulmonary Arterial Hypertension Open
View article: Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP)
Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP) Open
Background Fibrodysplasia Ossificans Progressiva (FOP) is a genetic, progressive and devastating disease characterized by severe heterotopic ossification (HO), loss of mobility and early death. There are no FDA approved medications. The ST…
View article: Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension Open
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. H…
View article: Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1 Open
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification (HO) of skeletal muscles, ligaments, tendons, and fascia. FOP is caused by muta…
View article: Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart
Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart Open
There is an increased appreciation for the importance of the right heart and pulmonary circulation in several disease states across the spectrum of pulmonary hypertension and left heart failure. However, assessment of the structure and fun…
View article: Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart
Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart Open
There is an increased appreciation for the importance of the right heart and pulmonary circulation in a number of disease states across the spectrum of pulmonary hypertension and left heart failure. However, assessment of the structure and…
View article: Metabolomic and transcriptomic signatures of chemogenetic heart failure
Metabolomic and transcriptomic signatures of chemogenetic heart failure Open
We have recently developed a new and robust “chemogenetic” animal model of heart failure that is based on a central feature of heart failure in humans: an increase in redox stress in the heart. Our chemogenetic approach exploits a recombin…