John M. Stafford
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View article: Predicting responsiveness to GLP-1 pathway drugs using real-world data
Predicting responsiveness to GLP-1 pathway drugs using real-world data Open
Background Medications targeting the glucagon-like peptide-1 (GLP-1) pathway are an important therapeutic class currently used for the treatment of Type 2 diabetes (T2D). However, there is not enough known about which subgroups of patients…
View article: Short-term HIIT impacts HDL function differently in lean, obese, and diabetic subjects
Short-term HIIT impacts HDL function differently in lean, obese, and diabetic subjects Open
Introduction High density lipoproteins (HDL) exert cardiovascular protection in part through their antioxidant capacity and cholesterol efflux function. Effects of exercise training on HDL function are yet to be well established, while imp…
View article: Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion
Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion Open
Hepatic deletion of SHP improves fatty liver but worsens hepatic inflammation possibly by driving excess fatty acid oxidation, which is corrected by deletion of IFNγ specifically in myeloid cells. This suggests that hepatic SHP limits fatt…
View article: ATP10A deficiency results in male-specific infertility in mice
ATP10A deficiency results in male-specific infertility in mice Open
Over 8% of couples worldwide are affected by infertility and nearly half of these cases are due to male-specific issues where the underlying cause is often unknown. Therefore, discovery of new genetic factors contributing to male-specific …
View article: Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice Open
Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide …
View article: Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice Open
Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide …
View article: Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice
Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice Open
Mounting evidence has shown that CETP has important physiological roles in adapting to chronic nutrient excess, specifically, to protect against diet-induced insulin resistance. However, the underlying mechanisms for the protective roles o…
View article: EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance
EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance Open
We previously showed that global deletion of the cytochrome P450 epoxygenase Cyp2c44, a major epoxyeicosatrienoic acid (EET) producing enzyme in mice, leads to impaired hepatic insulin signaling resulting in insulin resistance. This…
View article: EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance
EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance Open
We previously showed that global deletion of the cytochrome P450 epoxygenase Cyp2c44, a major epoxyeicosatrienoic acid (EET)–producing enzyme in mice, leads to impaired hepatic insulin signaling resulting in insulin resistance. This findin…
View article: EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance
EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance Open
We previously showed that global deletion of the cytochrome P450 epoxygenase Cyp2c44, a major epoxyeicosatrienoic acid (EET) producing enzyme in mice, leads to impaired hepatic insulin signaling resulting in insulin resistance. This…
View article: Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males Open
A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or insulinomatosis), with men more prone to diabetes than women.…
View article: Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice
Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice Open
Mechanisms of sex differences in hypertriglyceridemia remain poorly understood. Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid, glucose, and lipid metabolism. SHP also regulates transcriptional activity of s…
View article: Low‐density lipoprotein receptor is required for cholesteryl ester transfer protein to regulate triglyceride metabolism in both male and female mice
Low‐density lipoprotein receptor is required for cholesteryl ester transfer protein to regulate triglyceride metabolism in both male and female mice Open
Elevated triglycerides (TGs) and impaired TG clearance increase the risk of cardiovascular disease in both men and women, but molecular mechanisms remain poorly understood. Cholesteryl ester transfer protein (CETP) is a lipid shuttling pro…
View article: Sex-Biased Islet β Cell Dysfunction is Caused by the MODY MAFA S64F Variant by Inducing Premature Aging and Senescence in Males
Sex-Biased Islet β Cell Dysfunction is Caused by the MODY MAFA S64F Variant by Inducing Premature Aging and Senescence in Males Open
View article: Environmental Law Survey
Environmental Law Survey Open
View article: Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones
Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones Open
Mechanisms underlying changes in HDL composition caused by obesity are poorly defined, partly because mice lack expression of cholesteryl ester transfer protein (CETP), which shuttles triglyceride and cholesteryl ester between lipoproteins…
View article: Cholesteryl Ester Transfer Protein Impairs Triglyceride Clearance <i>via</i> Androgen Receptor in Male Mice
Cholesteryl Ester Transfer Protein Impairs Triglyceride Clearance <i>via</i> Androgen Receptor in Male Mice Open
Elevated postprandial triacylglycerols (TAG) are an important risk factor for cardiovascular disease. Men have higher plasma TAG and impaired TAG clearance compared to women, which may contribute to sex differences in risk of cardiovascula…
View article: Response by Mueller et al to Letter Regarding Article, “Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages”
Response by Mueller et al to Letter Regarding Article, “Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages” Open
View article: CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet
CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet Open
In clinical trials, inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels but does not robustly improve cardiovascular outcomes. Approximately two-thirds of trial participants are obese. Lower plasma CETP ac…
View article: Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages
Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages Open
Background: We previously showed that mice lacking MΦLRP1 -/- (low-density lipoprotein receptor–related protein 1 in macrophages) undergo accelerated atherosclerotic plaque formation due to changes in macrophages including increased apopto…
View article: Sex differences in lipid and lipoprotein metabolism
Sex differences in lipid and lipoprotein metabolism Open
The pathways that confer ASCVD protection for women are of potential therapeutic relevance. Despite protection relative to men, ASCVD is still the major cause of mortality in women. Additionally, diabetic women have similar ASCVD risk as d…
View article: GoF4R – Governance of the Interoperability Framework for Rail and Intermodal Mobility
GoF4R – Governance of the Interoperability Framework for Rail and Intermodal Mobility Open
In order to promote a modal shift towards green modes of transport such as rail, the intermodality between different transport modes should be improved. The development of multimodal travel information, planning and booking services and th…
View article: Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding
Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding Open
Estrogen signaling through hepatocyte ERα plays an important role in RCT and is protective against lipid retention in the artery wall during early stages of atherosclerosis in female mice fed a Western-type diet.
View article: High-Fat Feeding Does Not Disrupt Daily Rhythms in Female Mice because of Protection by Ovarian Hormones
High-Fat Feeding Does Not Disrupt Daily Rhythms in Female Mice because of Protection by Ovarian Hormones Open
Obesity in women is increased by the loss of circulating estrogen after menopause. Shift work, which disrupts circadian rhythms, also increases the risk for obesity. It is not known whether ovarian hormones interact with the circadian syst…
View article: Role of Estrogens in the Regulation of Liver Lipid Metabolism
Role of Estrogens in the Regulation of Liver Lipid Metabolism Open
View article: Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition
Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition Open
Objective— Antiatherosclerotic effects of tumor necrosis factor-α (TNF-α) blockade in patients with systemic inflammatory states are not conclusively demonstrated, which suggests that effects depend on the cause of inflammation. Macrophage…
View article: Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice Open
View article: Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets Open
Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. He…
View article: CETP Expression Protects Female Mice from Obesity-Induced Decline in Exercise Capacity
CETP Expression Protects Female Mice from Obesity-Induced Decline in Exercise Capacity Open
Pharmacological approaches to reduce obesity have not resulted in dramatic reductions in the risk of coronary heart disease (CHD). Exercise, in contrast, reduces CHD risk even in the setting of obesity. Cholesteryl Ester Transfer Protein (…