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View article: Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes
Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes Open
Gene expression is constantly regulated by gene regulatory networks that consist of multiple regulatory components to mediate cellular functions. An ideal tool for analyzing gene regulation processes would provide simultaneous measurements…
View article: Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues
Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues Open
Lipid membranes are key to the nanoscale compartmentalization of biological systems, but fluorescent visualization of them in intact tissues, with nanoscale precision, is challenging to do with high labeling density. Here, we report ultras…
View article: Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding
Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding Open
Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epito…
View article: Recording of cellular physiological histories along optically readable self-assembling protein chains
Recording of cellular physiological histories along optically readable self-assembling protein chains Open
Data and code from 'Recording of cellular physiological histories along optically readable self-assembling protein chains'.
View article: Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens
Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens Open
Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epito…
View article: Recording of cellular physiological histories along optically readable self-assembling protein chains
Recording of cellular physiological histories along optically readable self-assembling protein chains Open
Observing cellular physiological histories is key to understanding normal and disease-related processes, but longitudinal imaging is laborious and equipment-intensive. A tantalizing possibility is that cells could record such histories in …
View article: Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics Open
In order to analyze how a signal transduction network converts cellular inputs into cellular outputs, ideally one would measure the dynamics of many signals within the network simultaneously. We found that, by fusing a fluorescent reporter…
View article: Amount of fear extinction changes its underlying mechanisms
Amount of fear extinction changes its underlying mechanisms Open
There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (e…
View article: ABA renewal-inducing stimuli enhance Ser-831 phosphorylation of surface GluR1 in the LA synaptosomes.
ABA renewal-inducing stimuli enhance Ser-831 phosphorylation of surface GluR1 in the LA synaptosomes. Open
A. The behavioral procedure. On Day 7, the LA synaptosomal membranes were prepared immediately after a tone test (ABA-tone group). In the unpaired and extinction groups, one set of rats was killed for the preparation of LA synaptosomal mem…