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View article: Second-line therapy following osimertinib in metastatic <i>EGFR</i> -mutated non-small cell lung cancer at an academic medical center
Second-line therapy following osimertinib in metastatic <i>EGFR</i> -mutated non-small cell lung cancer at an academic medical center Open
Purpose FLAURA2 demonstrated that adding chemotherapy to osimertinib improved overall survival compared with osimertinib monotherapy in metastatic epidermal growth factor receptor -mutated ( EGFR -mut) non-small cell lung cancer (NSCLC). N…
View article: Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition
Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition Open
Metastatic cancer cells invade tissue, overcome nutrient stress, and survive transit to distant sites. Many of the mechanisms that support these processes are incompatible with proliferation. This study defines cellular transition states i…
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
Undifferentiated intestinal stem cells (ISCs), particularly those marked by Lgr5, are crucial for maintaining homeostasis and resolving injury. Lgr5+ cells in the crypt base constantly divide, pushing daughter cells upward along the crypt …
View article: Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression Open
View article: 993 – Myeloid Translocation Gene on Chromosome 16 (MTG16) is a Transcriptional Co-Repressor that Regulates Epithelial Response to Injury Via Homology Regions Nhr1 and Nhr3
993 – Myeloid Translocation Gene on Chromosome 16 (MTG16) is a Transcriptional Co-Repressor that Regulates Epithelial Response to Injury Via Homology Regions Nhr1 and Nhr3 Open
View article: Blood vessel epicardial substance reduces LRP6 receptor and cytoplasmic β-catenin levels to modulate Wnt signaling and intestinal homeostasis
Blood vessel epicardial substance reduces LRP6 receptor and cytoplasmic β-catenin levels to modulate Wnt signaling and intestinal homeostasis Open
Blood vessel epicardial substance (BVES, otherwise known as POPDC1) is an integral membrane protein known to regulate tight junction formation and epithelial–mesenchymal transition. BVES is underexpressed in a number of malignancies, inclu…
View article: Blood Vessel Epicardial Substance (BVES) in junctional signaling and cancer
Blood Vessel Epicardial Substance (BVES) in junctional signaling and cancer Open
Blood vessel epicardial substance (BVES) is a tight-junction associated protein that was originally discovered from a cDNA screen of the developing heart. Research over the last decade has shown that not only is BVES is expressed in cardia…
View article: BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability
BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability Open
View article: MTG16 is a tumor suppressor in colitis-associated carcinoma
MTG16 is a tumor suppressor in colitis-associated carcinoma Open
MTG16 is a member of the myeloid translocation gene (MTG) family of transcriptional corepressors. While MTGs were originally identified in chromosomal translocations in acute myeloid leukemia, recent studies have uncovered a role in intest…
View article: Myeloid translocation genes differentially regulate colorectal cancer programs
Myeloid translocation genes differentially regulate colorectal cancer programs Open
View article: BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis Open
Loss of BVES promotes inflammatory tumourigenesis through dysregulation of Wnt signalling and the oncogene c-Myc. BVES promoter methylation status may serve as a CAC biomarker.
View article: AOM/DSS Model of Colitis-Associated Cancer
AOM/DSS Model of Colitis-Associated Cancer Open
View article: A workshop on leadership for senior MD–PhD students
A workshop on leadership for senior MD–PhD students Open
Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established…
View article: Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage Open
Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selen…