Explanipedia

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases Open

Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu , et al. · 2025

Chronic inflammatory diseases of bone and soft tissue pose significant clinical challenges due to their complex pathogenesis and the limitations of conventional therapies, which often fail to address immune microenvironment dysregulation. …

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets Open

Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Lu Li , et al. · 2025

Circadian rhythms are intrinsic 24‐h biological cycles that govern various physiological processes. In addition to the hypothalamic suprachiasmatic nucleus, the circadian system is organized in multiple peripheral tissues, such as the brai…

Targeting mitochondrial copper(II) for epigenetic modulation of macrophage polarization to prevent senile osteoporosis Open

Wenqian Zhang, Weixian Hu, Yu‐An Xiong, Tao Chen, Chenyan Yu , et al. · 2025

Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing Open

Longyu Du, Chuanlu Lin, Haodong Hu, Yanzhi Zhao, Jiewen Liao , et al. · 2025

Photocatalytic CO-releasing spray hydrogel for in situ postoperative cancer treatment Open

Zhonghao Wang, Jun‐Jie Zhu, Bobin Mi, Ming Ni, Yuming Xue , et al. · 2025

Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration Open

Xudong Xie, Jun‐Li Yang, Chong Ding, Yiming Li, Fawwaz Ai-Smadi , et al. · 2025

A smart CO-releasing MnSiO3-based hydrogel enhances diabetic wound healing through NIR-triggered antibacterial, anti-inflammatory, and pro-regenerative mechanisms Open

Yukun Liu, Fei Gao, Shuai Liu, Zezhou Xu, Xuan Zhao , et al. · 2025

Diabetes is a growing global health concern often associated with chronic wounds characterized by persistent infection, excessive inflammation, and impaired angiogenesis. To address these challenges, we developed a multifunctional hydrogel…

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing Open

Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha , et al. · 2025

Impaired fracture healing in diabetic patients poses a persistent clinical challenge, with underlying mechanisms that remain to be fully elucidated. These findings reveal that high glucose microenvironments generate excessive reactive oxyg…

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis Open

Li Lü, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou , et al. · 2025

Continuously bacterial infection, undue oxidative stress, and inflammatory responses in the skin tissue microenvironment determine the delayed healing outcome of diabetic wounds, which remain a tough clinical challenge and need multifacete…

Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review Open

Yuan Xiong, Samuel Knoedler, Michael Alfertshofer, Bong‐Sung Kim, Dongsheng Jiang , et al. · 2025

Bidirectional modulation of glycolysis using a multifunctional nanocomposite hydrogel promotes bone fracture healing in type 2 diabetes mellitus Open

Shengming Zhang, Weixian Hu, Yanzhi Zhao, Yuheng Liao, Kangkang Zha , et al. · 2025

Low-frequency ultrasound-driven piezoelectric films repair neuro-immune circuits in diabetic wound healing Open

Chenyan Yu, Ying Hu, Xin Zhang, Kunwu Yu, Lang Chen , et al. · 2025

Application of Digital Technology-Assisted PBL in Clinical Education of Trauma Orthopedics (Preprint) Open

Bobin Mi · 2025

BACKGROUND Medical education has evolved significantly over the past few decades, with increasing emphasis on interactive and student-centered learning approaches. Traditional lecture-based learning (LBL), once the dominant method of inst…

TMED9: a potential therapeutic target and prognostic marker in glioma and its implications across pan-cancer contexts Open

Bobin Mi, Chaolin Li · 2025

Background The escalating global cancer burden, projected to reach 35 million new cases by 2050, underscores the urgent need for innovative cancer biomarkers to improve treatment efficacy and patient outcomes. The TMED family, particularly…

Conductive Hydrogel Inspires Neutrophil Extracellular Traps to Combat Bacterial Infections in Wounds Open

Lizhi Ouyang, Ze Lin, Xi He, Jiaqi Sun, Jiewen Liao , et al. · 2025

Thetreatment of infected wounds is currently a major challenge in clinical medicine, and enhancing antimicrobial and angiogenic capacity is one of the most common strategies. However, the current treatment makes it difficult to balance the…

Mulberry-inspired tri-act hydrogel for visual monitoring and enhanced diabetic wound repair Open

Zhenhe Zhang, Bobin Mi, Yuheng Liao, Pengzhen Bu, Xudong Xie , et al. · 2025

A Smart CO-Releasing MnSiO₃-Based Hydrogel Enhances Diabetic Wound Healing Through NIR-Triggered Antibacterial, Anti-Inflammatory, and Pro-Regenerative Mechanisms Open

Yukun Liu, Fei Gao, Shuai Liu, Zezhou Xu, Fan Yang , et al. · 2025

Enhancing Crosstalk between Macrophages and Fibroblasts Via Multifunctional Hydrogel Microneedles to Promote Diabetic Wound Healing Open

Jiewen Liao, Lu Li, Yu‐An Xiong, Lizhi Ouyang, Fawwaz Al-Smadi , et al. · 2025

The Potential of Photoacoustic Imaging in Detecting and Managing Complex Wounds Open

Haifeng Hu, Zeng ruiyin, Longyu Du, Weixian Hu, Chuanlu Lin , et al. · 2025

Photoacoustic imaging (PAI) is a promising emerging technology in biomedical imaging, particularly in wound healing. This review summarizes the applications of PAI in the detection and management of complex wounds, emphasizing its advantag…

Ni‐MOF Engineered System Targeting Macrophage Aurora A Kinase for Bone Loss Prevention Through PD‐L1 Activation Open

Wenqian Zhang, Shengming Zhang, Minghao He, Weixian Hu, Wenhao Han , et al. · 2024

Postmenopausal bone loss due to estrogen deficiency necessitates effective therapeutic strategies. Our study explores targeting macrophage Aurora A kinase to mitigate bone loss. Aurora A kinase phosphorylation is observed being increased i…

The ROS-responsive FA@Ni@HA hydrogel promotes infected wound healing in DIO mice through endogenous antimicrobial peptides and macrophage recruitment Open

Weixian Hu, Yanzhi Zhao, Shengming Zhang, Yue An, Samuel Knoedler , et al. · 2024

Nanoarchitecture‐Integrated Hydrogel Boosts Angiogenesis–Osteogenesis–Neurogenesis Tripling for Infected Bone Fracture Healing (Adv. Sci. 43/2024) Open

Kangkang Zha, Weixian Hu, Yuan Xiong, Shengming Zhang, Meijun Tan , et al. · 2024

Infected Fracture Healing In article number 2406439, Qian Feng, Guohui Liu, Bobin Mi, and co‐workers develop a pH‐responsive nanoarchitecture‐integrated hydrogel to treat bacteria‐infected fracture through controlled release of humic acids…

Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration Open

Yuan Xiong, Bobin Mi, Mohammad‐Ali Shahbazi, Tian Xia, Jun Xiao · 2024

Glutathione‐Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer Open

Jiangnan Shi, Guoqing Cui, Yongmei M. Jin, Bobin Mi, K Liu , et al. · 2024

Radiotherapy plays a crucial role in the treatment of advanced breast cancer, but the increased antioxidant system, especially the rise in glutathione (GSH), presents a significant obstacle to its effectiveness. To address this challenge, …

Nanoarchitecture‐Integrated Hydrogel Boosts Angiogenesis–Osteogenesis–Neurogenesis Tripling for Infected Bone Fracture Healing Open

Kangkang Zha, Weixian Hu, Yuan Xiong, Shengming Zhang, Meijun Tan , et al. · 2024

Infected fracture healing is a complicated process that includes intricate interactions at the cellular and molecular levels. In addition to angiogenesis and osteogenesis, the significance of neurogenesis in fracture healing has also been …

Research progress of gene therapy combined with tissue engineering to promote bone regeneration Open

Xiangyu Chu, Yuan Xiong, Li Lu, Yiqing Wang, Jing Wang , et al. · 2024

Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is a common clinical need. Meanwhile, many preclinical data have demonstrated that gene and c…

Hybrid biomaterial hydrogel loading iRGD&PS double modified lipid nanoparticles ameliorates diabetic wound healing through promoting efferocytosis and glycolysis-related macrophage reprogramming Open

Wenqian Zhang, Shengming Zhang, Samuel Knoedler, Wenhao Han, Kangkang Zha , et al. · 2024

Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity Open

Kang Huang, Bobin Mi, Yuan Xiong, Zhou Fu, Wentao Zhou , et al. · 2024

Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the wound repair process in diabetic patients, sign…

Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system Open

Bobin Mi, Yuan Xiong, Samuel Knoedler, Michael Alfertshofer, Adriana C. Panayi , et al. · 2024

Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional intera…

Retraction Note: M2 macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3 Open

Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu , et al. · 2024

Bobin Mi YOU? Author Swipe