Bobo Wang
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View article: Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis Open
The tumor suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinase that specifically removes H2A monoubiquitination at Lys119 (H2Aub) and plays a crucial role in the epigenetic regulation of gene expression through coo…
View article: Coal-straw co-digestion-induced biogenic methane production: perspectives on microbial communities and associated metabolic pathways
Coal-straw co-digestion-induced biogenic methane production: perspectives on microbial communities and associated metabolic pathways Open
This study assessed the impacts of wheat straw as a cosubstrate on coal biocoverion into methane and the associated mechanism within methane metabolic pathways. Co-digestion of coal with varying wheat straw concentrations resulted in a rem…
View article: Study on the Impact of Groundwater and Soil Parameters on Tunnel Deformation and Sensitivity Analysis
Study on the Impact of Groundwater and Soil Parameters on Tunnel Deformation and Sensitivity Analysis Open
Based on the Xiaolangdi North Bank Irrigation Area Project, this study combines numerical simulation and BP neural network methods to investigate the sensitivity of tunnel soil and its parameter inversion under continuous heavy rainfall. T…
View article: Determination of cAMP and protein content in dormant chlamydospore and non-dormant chlamydospore of Duddingtonia flagrans
Determination of cAMP and protein content in dormant chlamydospore and non-dormant chlamydospore of Duddingtonia flagrans Open
Duddingtonia flagrans, a nematode-eating fungus, is an effective component of animal parasitic nematode biocontrol agents. In the dried formulation, the majority of spores are in an endogenous dormant state. This study focuses on dormant c…
View article: Synergistic application of thermally-pretreated-biocatalyst and dark-fermentative process coupled with bioelectrohydrogenesis promotes biohydrogen production from agricultural straw wastes
Synergistic application of thermally-pretreated-biocatalyst and dark-fermentative process coupled with bioelectrohydrogenesis promotes biohydrogen production from agricultural straw wastes Open
This work investigated the feasibility of enhancing biohydrogen yield from agricultural wheat straw by introducing an electrohydrogenesis process into dark fermentation (DF) and using heat-pretreated activated sludge as inoculum as a strat…
View article: TXNDC12 inhibits pancreatic tumor cells ferroptosis by regulating GSH/GGT7 and promotes its growth and metastasis
TXNDC12 inhibits pancreatic tumor cells ferroptosis by regulating GSH/GGT7 and promotes its growth and metastasis Open
Background: Thioredoxin domain-containing protein 12 (TXNDC12) is upregulated in a variety of tumours, including pancreatic cancer (PAAD), and its high expression is closely associated with poor prognosis. However, the regulatory mechanism…
View article: Formation, Evolution, and Antioxidant Activity of Melanoidins in Black Garlic under Different Storage Conditions
Formation, Evolution, and Antioxidant Activity of Melanoidins in Black Garlic under Different Storage Conditions Open
Melanoidins (MLDs) are formed through the reaction of carbonyl compounds and amino compounds in the Maillard reaction (MR) during the heating or storage of food. In this study, the formation, chemical composition, and structural characteri…
View article: Microstructure characterization of different types of chlamydospores in <i>Arthrobotrys flagrans</i>
Microstructure characterization of different types of chlamydospores in <i>Arthrobotrys flagrans</i> Open
The morphological and structural differences of different types of chlamydospore of Arthrobotrys flagrans , a nematophagous fungus, were studied under light microscope and electron microscope to provide a reference for the biological contr…
View article: Microstructure characterization of different types of chlamydospores in Duddingtonia flagrans
Microstructure characterization of different types of chlamydospores in Duddingtonia flagrans Open
The morphological and structural differences of different types of chlamydospore of Duddingtonia flagrans, a nematophagous fungus, were studied under light microscope and electron microscope to provide reference for the biological control …
View article: PHOTOSYNTHETIC CHARACTERISTICS OF LARIX GMELINII SEEDLINGS UNDER DIFFERENT LIGHT INTENSITY
PHOTOSYNTHETIC CHARACTERISTICS OF LARIX GMELINII SEEDLINGS UNDER DIFFERENT LIGHT INTENSITY Open
To explore the effects of different light intensities on the physiological growth of Larix gmelinii seedlings, this study assessed three height grades of L. gmelinii seedlings (≤0.5-1, 0.5-1, and 1-3 m) under the following treatments: full…
View article: Using bioelectrohydrogenesis left-over residues as a future potential fertilizer for soil amendment
Using bioelectrohydrogenesis left-over residues as a future potential fertilizer for soil amendment Open
In this current research, the left-over residues collected from the dark fermentation-microbial electrolysis cells (DF-MEC) integrated system solely biocatalyzed by activated sludge during the bioconversion of the agricultural straw wastes…
View article: Synergistic Application of Molecular Markers and Community-Based Microbial Source Tracking Methods for Identification of Fecal Pollution in River Water During Dry and Wet Seasons
Synergistic Application of Molecular Markers and Community-Based Microbial Source Tracking Methods for Identification of Fecal Pollution in River Water During Dry and Wet Seasons Open
It is important to track fecal sources from humans and animals that negatively influence the water quality of rural rivers and human health. In this study, microbial source tracking (MST) methods using molecular markers and the community-b…
View article: Nitrate Modulates Lateral Root Formation by Regulating the Auxin Response and Transport in Rice
Nitrate Modulates Lateral Root Formation by Regulating the Auxin Response and Transport in Rice Open
Nitrate (NO3-) plays a pivotal role in stimulating lateral root (LR) formation and growth in plants. However, the role of NO3- in modulating rice LR formation and the signalling pathways involved in this process remain unclear. Phenotypic …
View article: Deciphering the initial products of coal during methanogenic bioconversion: Based on an untargeted metabolomics approach
Deciphering the initial products of coal during methanogenic bioconversion: Based on an untargeted metabolomics approach Open
Although the process of microbial degradation of coal to produce biomethane has got much attention from many research works, the products profiles of coal at the initial stage of methanogenic bioconversion are not clear yet. In this study,…
View article: Cystatin C-Based Renal Function in Predicting the Long-Term Outcomes of Chronic Total Occlusion After Percutaneous Coronary Intervention
Cystatin C-Based Renal Function in Predicting the Long-Term Outcomes of Chronic Total Occlusion After Percutaneous Coronary Intervention Open
Renal function estimated by various biomarkers predicting for adverse cardiovascular events has not been well-identified in received percutaneous coronary intervention (PCI) for chronic total occlusion (CTO), the advanced stages of atheros…
View article: Effectiveness of deep electroacupuncture with strong deqi and shallow electroacupuncture with no deqi for lumbar disk herniation: study protocol for a randomised controlled trial
Effectiveness of deep electroacupuncture with strong deqi and shallow electroacupuncture with no deqi for lumbar disk herniation: study protocol for a randomised controlled trial Open
Introduction Lumbar disk herniation (LDH) is a common cause of low back pain and dysfunction. Studies have shown that electroacupuncture (EA) can achieve pain relief in patients with LDH. However, there is a lack of evidence regarding the …
View article: Erratum to Simultaneous inhibition of PI3Ka and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
Erratum to Simultaneous inhibition of PI3Ka and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer Open
In the published [ Figure 1 ][1][1][2], errors appeared in [ Figure 1B ][1] on page 69. In [ Figure 1B ][1], bands for p-Akt S473, Akt, and Actin in H1355 cells were mistakenly placed. Here, we have updated [ Figure 1B ][1] to correct the …
View article: Effect of temperature, pH, physical and chemical factors on germination rate of the chlamydospores of the nematophagous fungus <i>Duddingtonia flagrans</i>
Effect of temperature, pH, physical and chemical factors on germination rate of the chlamydospores of the nematophagous fungus <i>Duddingtonia flagrans</i> Open
This study mainly investigated the effects of environmental factors on the germination/dormancy, sporulation and resistance of Duddingtonia flagrans chlamydospores. Results showed that the germination temperature of chlamydospores was >…
View article: Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer Open
Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRAS-mut…
View article: Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus
Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus Open
Hepatitis A virus (HAV) belongs to the family Picornaviridae. It is the pathogen of acute viral hepatitis caused by fecal-oral transmission. RNA viruses are sensed by pathogen-associated pattern recognition receptors (PRRs) such as Toll-li…
View article: Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer
Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer Open
PI3Ks are frequently hyper-activated in breast cancer and targeting PI3Kα has exhibited promising but variable response in preclinical and clinical settings. CYH33 is a novel PI3Kα-selective inhibitor in phase I clinical trial. We investig…
View article: Study on Effects of Electrical Stimulation on Rabbit Esophageal Body Motility In Vivo
Study on Effects of Electrical Stimulation on Rabbit Esophageal Body Motility In Vivo Open
Electric stimulation (ES) could induce contraction of intestinal smooth muscle. The aim of this study was to analyze the effects of ES on esophageal motility and the underlying mechanism in vivo. Twenty-eight rabbits were equipped with a p…