Bin Yang
YOU?
Author Swipe
View article: Integration of epidemiological surveys, network pharmacology, and molecular docking simulation to explore the potential key targets of propofol-induced euphoria
Integration of epidemiological surveys, network pharmacology, and molecular docking simulation to explore the potential key targets of propofol-induced euphoria Open
Propofol is a widely used anesthetic that has been associated with post-anesthetic euphoria, particularly among women. Since anhedonia is a core component of female sexual dysfunction (FSD), we aimed to evaluate the clinical incidence of p…
Prospective Dose-Finding of Esketamine for Suppressing Cervical Dilation Response in Ambulatory Hysteroscopy Under Monitored Anesthesia Care Open
ClinicalTrials.gov (identifier: NCT07034963). Principal Investigator: Lijuan Yan.
The G-branch off-the-shelf mixed branch endograft for thoracoabdominal aortic aneurysm: 1-year results from a prospective multicenter study Open
Background: The use of off-the-shelf multi-branched endografts for thoracoabdominal aortic aneurysm (TAAA) is increasing; however, these commercially available devices have limited anatomical feasibility for treating TAAA. This study aimed…
Sex-specific metabolic and central effects of GLP-1–estradiol conjugate in middle-aged rats on a standard or western diet Open
Middle age represents a critical window for metabolic and cognitive health, particularly in the context of rising obesity and diabetes rates. Glucagon-like peptide-1 (GLP-1)-based therapies, which regulate blood glucose and body weight, sh…
Innate immune signaling in a sponge reveals ancient origin of host-symbiont recognition Open
Innate immunity in animals functions both to defend against pathogens and to regulate interactions with beneficial microbes. Although these dual roles suggest deep evolutionary roots, it remains unclear whether ancestral functions of the i…
Compassion fatigue among medical students and its relationship to medical career choice: a cross-sectional survey Open
Compassion fatigue is common among medical students and may significantly influence their intention to pursue a medical career after graduation. Educational institutions, medical facilities, and relevant departments should prioritize addre…
Sex-Specific Metabolic and Central Effects of GLP-1–Estradiol Conjugate in Middle-Aged Rats on a Standard or Western Diet Open
Middle age represents a critical window for metabolic and cognitive health, particularly in the context of rising obesity and diabetes rates. Glucagon-like peptide-1 (GLP-1)-based therapies, which regulate blood glucose and body weight, sh…
View article: A neonate with meningitis caused by probiotic-related Clostridium butyricum
A neonate with meningitis caused by probiotic-related Clostridium butyricum Open
This is the first report of C. butyricum infection in neonates, highlighting the importance for prudence in administrating probiotics for neonates, particularly in high-risk groups such as preterm infants, those with central venous cathete…
A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans Open
Single molecules that combine complementary modes of action with glucagon-like peptide-1 receptor (GLP-1R) agonism are best-in-class therapeutics for obesity treatment. NN1706 (MAR423, RO6883746) is a fatty-acylated tri-agonist designed fo…
Simultaneous capture of chromatin accessibility and gene expression data from single larvae and postlarvae of the marine sponge Amphimedon queenslandica v1 Open
Understanding gene regulation networks is crucial to unravelling the molecular mechanisms behind a wide range of biological processes in all animals, but most existing methods are heavily tailored towards model organisms. Here we present a…
View article: Association of Perioperative Nursing Care with Incidence of Surgical Site Infections and Short-Term Outcomes in Primary Liver Cancer Patients: A Retrospective Comparison with Standard Care
Association of Perioperative Nursing Care with Incidence of Surgical Site Infections and Short-Term Outcomes in Primary Liver Cancer Patients: A Retrospective Comparison with Standard Care Open
PNC emerged as an independent risk factor for SSIs in PLC patients undergoing LS. Thus, the provision of PNC is crucial for reducing the risk of SSIs and improving short-term outcomes in PLC patients undergoing LS.
View article: The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men
The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men Open
An increasing number of treatment guidelines recommend rapid initiation of antiretroviral therapy (ART) after the diagnosis of human immunodeficiency virus (HIV) infection. However, data on the association between rapid ART initiation and …
Unravelling distinct patterns of metagenomic surveillance and respiratory microbiota between two P1 genotypes of <i>Mycoplasma pneumoniae</i> Open
To unravel distinct patterns of metagenomic surveillance and respiratory microbiota between Mycoplasma pneumoniae (M. pneumoniae) P1-1 and P1-2 and to explore the impact of the COVID-19 pandemic on epidemiological features, we conducted a …
View article: Dopamine receptors and organ fibrosis
Dopamine receptors and organ fibrosis Open
Organ fibrosis, considered as a major global health concern, is a pathological condition often occurring after tissue injury in various organs. The pathogenesis of fibrosis involves multiple phases and multiple cell types. Dopamine is invo…
Evaluation of the value of combined thyroid function-related indexes in the prognosis prediction of patients with differentiated thyroid cancer Open
This study aims to evaluate the prognostic significance of thyroid function-related indices in patients with differentiated thyroid cancer (DTC). This retrospective analysis included 90 patients diagnosed with DTC and treated at our hospit…
View article: Anatomical predispositions for silent cerebral infarction postcarotid artery stenting: a retrospective cohort
Anatomical predispositions for silent cerebral infarction postcarotid artery stenting: a retrospective cohort Open
Background: Silent cerebral infarction (SCI) that manifests following carotid artery stenting (CAS) has been postulated to correlate with cognitive decline, the onset of dementia, and an increased risk of subsequent cerebrovascular events.…
View article: Epidemic features and megagenomic analysis of childhood <i>Mycoplasma pneumoniae</i> post COVID-19 pandemic: a 6-year study in southern China
Epidemic features and megagenomic analysis of childhood <i>Mycoplasma pneumoniae</i> post COVID-19 pandemic: a 6-year study in southern China Open
With the atypical rise of Mycoplasma pneumoniae infection (MPI) in 2023, prompt studies are needed to determine the current epidemic features and risk factors with emerging trends of MPI to furnish a framework for subsequent investigations…
Safety and efficacy of remimazolam tosilate combined with low-dose fentanyl for procedural sedation in obese patients undergoing gastroscopy: study protocol for a single-centre, double-blind, randomised controlled trial Open
Introduction Obese patients are susceptible to hypoxaemia during procedural sedation. Propofol combined with low-dose opioids is commonly used as a sedation strategy, but it can exacerbate hypoxaemia by causing cardiopulmonary depression a…
Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis Open
Exosomes derived from BMSCs, serving as carriers for delivering miR-125b-5p, can downregulate STAT3, thereby inhibiting macrophage pyroptosis and alleviating sepsis-associated ALI. These significant findings provide valuable insights into …
Effect of internal jugular vein catheterization on intracranial pressure and postoperative cognitive function in patients undergoing robot-assisted laparoscopic surgery Open
Background We aimed to evaluate the effects of internal jugular vein (IJV) catheterization on intracranial pressure (ICP) and postoperative delirium (POD) during robot-assisted laparoscopic surgery by measuring the optic nerve sheath diame…
An analysis of nutritional risk factors in older adults with gastrointestinal tumours Open
Older adults with gastrointestinal cancer had a higher proportion of nutritional risk, and L3 SMI, grip strength/muscle strength were independent risk factors for nutritional risk. In clinical practice, attention to nutritional risk screen…
View article: Supplementary Figure S3 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING
Supplementary Figure S3 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING Open
Single-cell RNA-seq reveals the distinctive functional composition of immune cells in MET amplification patients
Supplementary Methods, Figures Legends 1-7 from Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer Open
PDF file - 78K
Data from Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer Open
Purpose: The Hedgehog (Hh) pathway has emerged as an important pathway in multiple tumor types and is thought to be dependent on a paracrine signaling mechanism. The purpose of this study was to determine the role of pancreatic cancer-asso…
Supplementary Figure S5 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING Open
METi treatment significantly boosted CD8+ cytotoxic T cells and NK infiltration in MET OE tumors
Supplementary Figure S5 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING Open
METi treatment significantly boosted CD8+ cytotoxic T cells and NK infiltration in MET OE tumors