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View article: Plasma p-tau <sub>217</sub> correlates strongly with cerebrospinal fluid Aβ <sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men
Plasma p-tau <sub>217</sub> correlates strongly with cerebrospinal fluid Aβ <sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men Open
Background Plasma phosphorylated tau 217 (p-tau 217 ) is a robust biomarker of Alzheimer's disease (AD) pathology. However, its full potential as a dynamic marker has still not been verified in very old persons, i.e., those with the highes…
View article: Having Plans for the Future in Very Old People
Having Plans for the Future in Very Old People Open
This study aimed to investigate the prevalence of having plans for the future among very old people and the factors associated with having such plans. A longitudinal population-based study with home visits for 85-, 90-, and ≥95-year-old pa…
View article: Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study
Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study Open
Background: Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer’s disease (AD). Objective: We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation t…
View article: Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults
Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults Open
Background: Herpesviruses have been proposed to be involved in Alzheimer’s disease development as potentially modifiable pathology triggers. Objective: To investigate associations of serum antibodies for herpes simplex virus (HSV)-1 and cy…
View article: Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century
Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century Open
Background: Long-increasing dementia incidence and prevalence trends may be shifting. Whether such shifts have reached the very old is unknown. Objective: To investigate temporal trends in the incidence of dementia and cognitive impairment…
View article: VALZ‐Pilot: High‐dose valacyclovir treatment in patients with early‐stage Alzheimer's disease
VALZ‐Pilot: High‐dose valacyclovir treatment in patients with early‐stage Alzheimer's disease Open
Introduction Herpes simplex virus (HSV) may be involved in Alzheimer's disease (AD) pathophysiology. The antiviral valacyclovir inhibits HSV replication. Methods This phase‐II pilot trial involved valacyclovir administration (thrice daily,…
View article: Long-Term Time Trends in Reactivated Herpes Simplex Infections and Treatment in Sweden.
Long-Term Time Trends in Reactivated Herpes Simplex Infections and Treatment in Sweden. Open
Background: Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population. Methods: The study comprised 2,879…
View article: Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and <i>Chlamydophila pneumoniae</i>
Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and <i>Chlamydophila pneumoniae</i> Open
Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties. Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex v…
View article: Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study
Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study Open
Introduction In this nested case‐control study, we investigated if antiviral treatment given prior to onset of Alzheimer's disease (AD) could influence incident AD. Methods From a large population‐based cohort study in northern Sweden, 262…
View article: Herpesvirus infections, antiviral treatment, and the risk of dementia—a registry‐based cohort study in Sweden
Herpesvirus infections, antiviral treatment, and the risk of dementia—a registry‐based cohort study in Sweden Open
Introduction Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against de…
View article: An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype
An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype Open
Increasing evidence implicates HSV type 1 (HSV1) in the pathogenesis of late-onset Alzheimer disease (AD). HSV1 has evolved highly sophisticated strategies to evade host immunosurveillance. One strategy involves encoding a decoy Fcγ recept…
View article: Urea dilution of serum for reproducible anti-HSV1 IgG avidity index
Urea dilution of serum for reproducible anti-HSV1 IgG avidity index Open
The method allows for AI scoring of anti-HSV1 IgG from individual human sera with a single measurement. The least significant change between two measurements at the p < 0.05 level was estimated at 5.4 and 3.2 points, respectively, for the …
View article: A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease
A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease Open
Introduction Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis. Methods Plasma from 360 AD cases, obtained on average 9.6 years before diag…
View article: Systolic blood pressure decline in very old individuals is explained by deteriorating health
Systolic blood pressure decline in very old individuals is explained by deteriorating health Open
Declining systolic blood pressure (SBP) is common in very old age and is associated with adverse events, such as dementia. Knowledge of factors associated with SBP changes could explain the etiology of this decline in SBP. This study inves…
View article: MAPPING LONGITUDINAL BLOOD PRESSURE CHANGE AND ASSOCIATED FACTORS AMONG VERY OLD INDIVIDUALS
MAPPING LONGITUDINAL BLOOD PRESSURE CHANGE AND ASSOCIATED FACTORS AMONG VERY OLD INDIVIDUALS Open
Declining systolic blood pressure (SBP) is common in very old age and it is associated with adverse events, such as dementia. Knowledge of factors associated with SBP change could be used to formulate preventive strategies. This study inve…
View article: High blood pressure as a risk factor for incident stroke among very old people
High blood pressure as a risk factor for incident stroke among very old people Open
High SBP (≥160 mmHg) and DBP (≥90 mmHg) and atrial fibrillation appeared to be risk factors for incident stroke among very old people.
View article: The association between SBP and mortality risk differs with level of cognitive function in very old individuals
The association between SBP and mortality risk differs with level of cognitive function in very old individuals Open
In people aged at least 85 years, the association of SBP with mortality appears to differ with respect to MMSE score. Very old individuals with very severe cognitive impairment and low or high BP may have increased mortality risk.
View article: Blood pressure in very old age : determinants, adverse outcomes, and heterogeneity
Blood pressure in very old age : determinants, adverse outcomes, and heterogeneity Open
Background: High blood pressure (BP) is the leading risk factor for disease and mortality worldwide. However, risks associated with high BP in very old age (≥ 80 or ≥ 85 years) are not entirely understood, as the majority of scientific stu…