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View article: White matter structural changes in the visual pathway of thyroid-associated ophthalmopathy patients: a free water and multi-shell diffusion imaging study
White matter structural changes in the visual pathway of thyroid-associated ophthalmopathy patients: a free water and multi-shell diffusion imaging study Open
Background Compared to single-shell diffusion tensor imaging (DTI), free water (FW) and neurite orientation dispersion and density imaging (NODDI) offer a more comprehensive evaluation of microstructural alterations in cerebral white matte…
View article: Combining biomarkers to predict the disease activity of graves’ ophthalmopathy: a combinatory model of the NLR, TRAb and FT4
Combining biomarkers to predict the disease activity of graves’ ophthalmopathy: a combinatory model of the NLR, TRAb and FT4 Open
Purpose The aim of this study was to identify potential biomarkers associated with active Graves’ ophthalmopathy (GO) and develop a model for predicting the occurrence and progression of active GO. Methods A retrospective study was conduct…
View article: Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota
Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota Open
Butyrate ameliorates several of the symptoms of GO, lowering GO orbital fibroblast viability, adipogenesis, and TGF-β1-induced fibrosis without damaging normal fibroblasts. Butyrate normalizes thyroid function in a GO mouse model, improves…
View article: Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy
Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy Open
Our study indicated that ferroptosis plays an important role in the pathogenesis of GO and that simvastatin may induce ferroptosis, suggesting that this drug could serve as a novel therapeutic agent for GO.
View article: Changes in the gut microbiota of patients with Graves' orbitopathy according to severity grade
Changes in the gut microbiota of patients with Graves' orbitopathy according to severity grade Open
Background To explore the changes of gut microbiota in Graves' orbitopathy (GO) patients of different severity grades and to identify the pathogenic bacteria of GO and the associated mechanism. Methods A total of 18 healthy controls and 62…
View article: The mRNA m6A reader YTHDF2 suppresses the proliferation and migration of pterygium fibroblasts
The mRNA m6A reader YTHDF2 suppresses the proliferation and migration of pterygium fibroblasts Open
BACKGROUND: Pterygium is a common, benign ocular surface disease. Its characteristics, such as hyper-proliferation, anti-apoptotic behavior, and high recurrence rate, contribute to the tumourigenic-like features. Emerging evidence has show…
View article: Unusual rapid resolution of postsclerectomy exudative retinal detachment with topical NSAIDs therapy in a case of nanophthalmos
Unusual rapid resolution of postsclerectomy exudative retinal detachment with topical NSAIDs therapy in a case of nanophthalmos Open
Nanophthalmos is a developmental ocular malformation that has been associated with high risks of uveal effusion syndrome and exudative retinal detachment (ERD). A variety of surgical procedures and systemic/topical steroids have been descr…
View article: Original endoscopic orbital decompression of lateral wall through hairline approach for Graves’ ophthalmopathy: an innovation of balanced orbital decompression
Original endoscopic orbital decompression of lateral wall through hairline approach for Graves’ ophthalmopathy: an innovation of balanced orbital decompression Open
This surgery is effective, safe, and cosmetic. Effective balanced orbital decompression can be achieved by using this original and innovative surgery method. The whole manipulation is safe and controllable under endoscope. The postoperativ…
View article: Low density lipoprotein - rosiglitazone - chitosan-calcium alginate/nanoparticles inhibition of human tenon's fibroblasts activation and proliferation
Low density lipoprotein - rosiglitazone - chitosan-calcium alginate/nanoparticles inhibition of human tenon's fibroblasts activation and proliferation Open
Anti-fibrotic therapeutic methods with safety and efficiency after glaucoma filtration surgery (GFS) are desirable. In our previous study, by using Human Tenon's Fibroblasts (HTFs) as a model, we proved the expression of peroxisome prolife…
View article: Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the disease
Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the disease Open
The present study aimed to investigate the association between the expression of sex-determining region Y box 2 (SOX2) in retinoblastoma (Rb) tissues and peripheral blood, and the clinicopathological characteristics of Rb. The expression o…
View article: MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy.
MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy. Open
The present study shows that miR-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from TAO, and acts as a mediator in TGF-β1-induced collagen production. These data predict a close association between …
View article: Effect of radiotherapy on moderate and severe thyroid associated ophthalmopathy: a double blind and self-controlled study.
Effect of radiotherapy on moderate and severe thyroid associated ophthalmopathy: a double blind and self-controlled study. Open
The treatment of radiotherapy is effective for the TAO in the moderate and severe active period.