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View article: EPCO-08. METHYLATION-BASED CLASSIFIER IMPROVES MENINGIOMA PROGNOSTICATION
EPCO-08. METHYLATION-BASED CLASSIFIER IMPROVES MENINGIOMA PROGNOSTICATION Open
Meningiomas are the most common central nervous system tumors and, while typically benign, a subset exhibits aggressive behavior or recurrence, necessitating repeated interventions. The current WHO classification, which comprises 15 subtyp…
View article: BIOM-36. NONINVASIVE CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMORS USING CFDNA METHYLATION PROFILING: DEVELOPMENT AND VALIDATION OF A MULTICLASS RANDOM FOREST MODEL
BIOM-36. NONINVASIVE CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMORS USING CFDNA METHYLATION PROFILING: DEVELOPMENT AND VALIDATION OF A MULTICLASS RANDOM FOREST MODEL Open
BACKGROUND Accurate classification of central nervous system (CNS) tumors using tissue samples has been well-established. However, a noninvasive approach utilizing liquid biopsy samples offers significant advantages for patient diagnosis a…
View article: Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics
Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics Open
Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models. Herein, we curated 1,842 public placental methylomes and…
View article: Immunosequencing and Profiling of T Cells at the Maternal–Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis
Immunosequencing and Profiling of T Cells at the Maternal–Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis Open
T cells are implicated in the pathophysiology of preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Specifically, maternal decidual T cells infiltrate the chorioamniotic membranes in chronic chorioamn…
View article: Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma
Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma Open
Background Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. …
View article: Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention
Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention Open
Objectives The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimeste…
View article: Human Plasma Proteome During Normal Pregnancy
Human Plasma Proteome During Normal Pregnancy Open
The human plasma proteome is underexplored despite its potential value for monitoring health and disease. Herein, using a recently developed aptamer-based platform, we profiled 7288 proteins in 528 plasma samples from 91 normal pregnancies…
View article: Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma Open
Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we …
View article: Fetal and maternal NLRP3 signaling is required for preterm labor and birth
Fetal and maternal NLRP3 signaling is required for preterm labor and birth Open
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria. However, the molecular mechanisms underlyin…
View article: The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix
The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix Open
Preterm birth, the leading cause of perinatal morbidity and mortality, is associated with increased risk of short- and long-term adverse outcomes. For women identified as at risk for preterm birth attributable to a sonographic short cervix…
View article: Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts
Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts Open
In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level. Longitudinal changes in the known protein-coding transcriptome during norma…
View article: Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth Open
The complex physiologic process of parturition includes the onset of labor, which requires the orchestrated stimulation of a common pathway involving uterine contractility, cervical ripening, and chorioamniotic membrane activation. However…
View article: The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II
The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II Open
Fetal inflammatory response syndrome (FIRS) is strongly associated with neonatal morbidity and mortality and can be classified as type I or type II. Clinically, FIRS type I and type II are considered as distinct syndromes, yet the molecula…
View article: Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth Open
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to …
View article: RNA Sequencing Reveals Distinct Immune Responses in the Chorioamniotic Membranes of Women with Preterm Labor and Microbial or Sterile Intra-amniotic Inflammation
RNA Sequencing Reveals Distinct Immune Responses in the Chorioamniotic Membranes of Women with Preterm Labor and Microbial or Sterile Intra-amniotic Inflammation Open
Preterm labor precedes premature birth, the leading cause of neonatal morbidity and mortality worldwide. Preterm labor can either occur in the context of microbe-associated intra-amniotic inflammation (i.e., intra-amniotic infection) or in…
View article: RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection
RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection Open
Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the mother and fetus as well as severe long-term neonatal morbid…
View article: Pregnancy-specific transcriptional changes upon endotoxin exposure in mice
Pregnancy-specific transcriptional changes upon endotoxin exposure in mice Open
Objectives Pregnant women are more susceptible to certain infections; however, this increased susceptibility is not fully understood. Herein, systems biology approaches were utilized to elucidate how pregnancy modulates tissue-specific hos…
View article: Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth Open
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to …
View article: Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia
Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia Open
The Fas/Fas ligand (FASL) system and Elabela-apelin receptor signaling pathways are implicated in the pathophysiology of preeclampsia. The aim of the current study was to investigate whether a model combining the measurement of sFas and El…
View article: Additional file 13 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 13 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 13: Table S7. Genes differentially spliced with gestational age (term versus midtrimester). The table includes results for the single most-significant exon or exon junction based on splicing index analysis. The columns incl…
View article: Additional file 12 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 12 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 12: Table S6. Gene Atlas-based tissues and cell types associated with increased expression in midtrimester vs term samples. Columns are as shown in the Table S3 legend
View article: Additional file 14 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 14 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 14: Table S8. Biological processes from DFLAT database associated with gestational-age differential splicing but not with differential expression from midtrimester to term. Columns are as shown in the Table S3 legend
View article: Additional file 9 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 9 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 9: Table S3. Biological processes from DFLAT database associated with gestational age differential expression from midtrimester to term. Count: number of differentially expressed genes associated with the ontology. Size: to…
View article: Additional file 15 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 15 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 15: Table S9. MSigDB database canonical pathways associated with gestational-age differential splicing but not with differential expression from midtrimester to term. Columns are as shown in the Table S3 legend
View article: Additional file 11 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 11 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 11: Table S5. Gene Atlas-based tissues and cell types associated with increased expression in term vs midtrimester samples. Columns are as shown in the Table S3 legend
View article: Additional file 16 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy
Additional file 16 of Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy Open
Additional file 16: Table S10. Genes differentially expressed with fetal sex. Columns are the same as in Table S1, except that the comparison is between pregnancies with a male versus a female fetus