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View article: Insights into Vascular Changes in Hip Degenerative Disorders: An Observational Study
Insights into Vascular Changes in Hip Degenerative Disorders: An Observational Study Open
Background: The epiphyseal vascularization of long bones generates a particular flow pattern that is important for adequate angiogenesis to be achieved. Imaging reveals that vessel development in murine long bone involves the expansion and…
View article: Immunohistochemical and Ultrastructural Study of the Degenerative Processes of the Hip Joint Capsule and Acetabular Labrum
Immunohistochemical and Ultrastructural Study of the Degenerative Processes of the Hip Joint Capsule and Acetabular Labrum Open
Background/Objectives: Degenerative processes of the hip joint increasingly affect not only the articular cartilage but also periarticular structures such as the joint capsule and acetabular labrum. This study aimed to investigate the stru…
View article: Systemic Impact of Platelet Activation in Abdominal Surgery: From Oxidative and Inflammatory Pathways to Postoperative Complications
Systemic Impact of Platelet Activation in Abdominal Surgery: From Oxidative and Inflammatory Pathways to Postoperative Complications Open
Although platelets have been traditionally thought of to be essential hemostasis mediators, new research shows how important they are for controlling cellular oxidative stress, inflammatory processes, and immunological responses—particular…
View article: Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration
Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration Open
A varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids in…
View article: A Prospective Randomized Pilot Study on the Efficacy of a Dietary Supplementation Regimen of Vitamin E and Selenium for the Prevention of Fluoroquinolone-Induced Tendinopathy
A Prospective Randomized Pilot Study on the Efficacy of a Dietary Supplementation Regimen of Vitamin E and Selenium for the Prevention of Fluoroquinolone-Induced Tendinopathy Open
Background: Fluoroquinolone-induced tendinopathy is a clinically significant adverse effect associated with this class of antibiotics, particularly affecting the Achilles tendon. Despite its growing recognition, the precise pathophysiologi…
View article: The Therapeutic Use and Potential of MSCs: Advances in Regenerative Medicine
The Therapeutic Use and Potential of MSCs: Advances in Regenerative Medicine Open
Mesenchymal stem cells (MSCs) have emerged as a relevant strategy in regenerative medicine due to their multipotent differentiation capacity, immunomodulatory properties, and therapeutic applications in various medical fields. This review …
View article: Venous Thromboembolism Prophylaxis in Hemophilic Patients Undergoing Total Hip or Knee Arthroplasty: Insights from a Single-Center Experience
Venous Thromboembolism Prophylaxis in Hemophilic Patients Undergoing Total Hip or Knee Arthroplasty: Insights from a Single-Center Experience Open
Background and Objectives: Total hip replacement and total knee arthroplasty carry a high risk of postoperative venous thromboembolism (VTE); therefore, anticoagulation prophylaxis is recommended in these patients. Unfortunately, there are…
View article: The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances
The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances Open
Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemost…
View article: Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance
Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance Open
Orthopedic infections are challenging pathologies that impose a heavy burden on patients and the healthcare system. Antimicrobial therapy is a critical component of the successful management of orthopedic infections, but its effectiveness …
View article: Multidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis
Multidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis Open
(1) Background: Necrotizing fasciitis is known as a severe condition with a high risk of mortality, placing it among the most feared infections. In most cases, it has a polymicrobial etiology (type 1), requiring complex treatment that is c…
View article: New Insights into the Pathophysiology of Coronary Artery Aneurysms
New Insights into the Pathophysiology of Coronary Artery Aneurysms Open
Coronary aneurysms are typically defined as sections of a coronary artery where the diameter is more than 1.5 times that of an adjacent normal segment. In rare circumstances, these aneurysms can become exceedingly large, leading to the cla…
View article: Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy
Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy Open
Hemophilia, which is a rare disease, results from congenital deficiencies of coagulation factors VIII and IX, respectively, leading to spontaneous bleeding into joints, resulting in hemophilic arthropathy (HA). HA involves complex processe…
View article: Debates Surrounding the Use of Antithrombotic Therapy in Hemophilic Patients with Cardiovascular Disease: Best Strategies to Minimize Severe Bleeding Risk
Debates Surrounding the Use of Antithrombotic Therapy in Hemophilic Patients with Cardiovascular Disease: Best Strategies to Minimize Severe Bleeding Risk Open
Navigating through antithrombotic therapy in patients with both hemophilia and cardiovascular pathology presents a complex scenario with inherent challenges and opportunities. The presence of hemophilia, characterized by impaired blood clo…
View article: Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective
Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective Open
With the rise in longevity within the population, medicine continues to encounter fresh hurdles necessitating prompt actions, among which are those associated with hip joint aging. Age-related arthropathies encompass damage to bones’ artic…
View article: CARDIOVASCULAR PATTERN IN HIP OSTEOPOROSIS ETIOPATHOGENY- A SILENT DENTAL RISK –
CARDIOVASCULAR PATTERN IN HIP OSTEOPOROSIS ETIOPATHOGENY- A SILENT DENTAL RISK – Open
Aim of the study The purpose of the study is to investigate whether bone quality information obtained by CT, could provide valuable information about the health of the patient's bone system, the cardiovascular one and, implicitly dental st…
View article: Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Perilla leaves Extracts
Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Perilla leaves Extracts Open
(1) Background: This study aimed to outline the antioxidant, antitumoral, and cytotoxic proprieties of various types of Perilla frutescens extracts obtained from the leaves of the species. (2) Methods: We determined total polyphenols, flav…
View article: Assessing the <em>In Vitro</em> Cytotoxicity, Antitumoral and Antioxidant Properties of Polyphenol‐rich <em>Perilla leaves </em>Extracts
Assessing the <em>In Vitro</em> Cytotoxicity, Antitumoral and Antioxidant Properties of Polyphenol‐rich <em>Perilla leaves </em>Extracts Open
(1) Background: This study aimed to outline the antitumoral, antioxidant, and cytotoxic proprie-ties of various types of Perilla frutescens extracts obtained from the leaves of the species; (2) Methods: We determined total polyphenols, fla…
View article: Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure?
Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? Open
Acute heart failure (AHF) is a life-threatening condition with high morbidity and mortality. Even though this pathology has been extensively researched, there are still challenges in establishing an accurate and early diagnosis, determinin…
View article: Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)
Role of arterial hypertension and angiotensin II in chronic kidney disease (Review) Open
Chronic kidney disease (CKD) is a major public health issue, due to its effect on the quality of life of patients and by the huge costs incurred in treating this disease. It is an irreversible process, characterized by the progressive loss…
View article: Cardiac Biomarkers in Sports Cardiology
Cardiac Biomarkers in Sports Cardiology Open
Sustained physical activity induces morphological and functional changes in the cardiovascular system. While mostly physiological, they can also become a trigger for major adverse cardiovascular events, the most severe of which are sudden …
View article: ECG and Biomarker Profile in Patients with Acute Heart Failure: A Pilot Study
ECG and Biomarker Profile in Patients with Acute Heart Failure: A Pilot Study Open
Background: Biomarkers, electrocardiogram (ECG) and Holter ECG are basic, accessible and feasible cardiac investigations. The combination of their results may lead to a more complex predictive model that may improve the clinical approach i…
View article: Floating-dislocated elbow in adults: Case reports and literature review
Floating-dislocated elbow in adults: Case reports and literature review Open
Rationale: Floating-dislocated elbow is a severe and extremely rare injury in adults. Reviewing the literature, we found around 6 case reports regarding floating-dislocated elbow in adults. Patient concerns and diagnoses: We report 2 cases…
View article: Schwannoma of the Upper Limb: Retrospective Study of a Rare Tumor with Uncommon Locations
Schwannoma of the Upper Limb: Retrospective Study of a Rare Tumor with Uncommon Locations Open
Background: Although schwannoma (neurilemmoma) is the most common tumor of the peripheral nerve, its low incidence, slow growth and vague symptoms often lead to misdiagnosis or delayed diagnosis. The aim of the study is to present a series…
View article: Pain Intensity and Degree of Disability after Fragility Fractures of the Pelvis
Pain Intensity and Degree of Disability after Fragility Fractures of the Pelvis Open
Background and objectives: Fragility fractures of the pelvis (FFP) are of increasing interest lately, being associated with a loss of mobility and affecting the quality of life. The aim of our study was to investigate the effect of FFP on …
View article: Connections between Orthopedic Conditions and Oxidative Stress: Current Perspective and the Possible Relevance of Other Factors, Such as Metabolic Implications, Antibiotic Resistance, and COVID-19
Connections between Orthopedic Conditions and Oxidative Stress: Current Perspective and the Possible Relevance of Other Factors, Such as Metabolic Implications, Antibiotic Resistance, and COVID-19 Open
The general opinion in the literature is that these topics remain clearly understudied and underrated, with many unknown aspects and with controversial results in the respective areas of research. Based on the previous experience of our gr…
View article: Cold Atmospheric Plasma, Platelet-Rich Plasma, and Nitric Oxide Synthesis Inhibitor: Effects Investigation on an Experimental Model on Rats
Cold Atmospheric Plasma, Platelet-Rich Plasma, and Nitric Oxide Synthesis Inhibitor: Effects Investigation on an Experimental Model on Rats Open
The evolution of reconstructive methods for defects of the human body cannot yet replace the use of flap surgery. Research is still preoccupied with the ideal techniques for offering the best chances of survival of the flaps. In our study,…
View article: Biomarkers Utility: At the Borderline between Cardiology and Neurology
Biomarkers Utility: At the Borderline between Cardiology and Neurology Open
Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research …
View article: Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)
Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review) Open
Biocompatibility is one of the mandatory requirements for the clinical use of biomaterials in orthopedics. It refers to the ability of a biomaterial to perform its function without eliciting toxic or injurious effects on biological systems…