Bogdan Mirăuță
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View article: From the establishment of a national bioinformatics society to the development of a national bioinformatics infrastructure
From the establishment of a national bioinformatics society to the development of a national bioinformatics infrastructure Open
We describe the evolution of a bioinformatics national capacity from scattered professionals into a collaborative organisation, and advancements in the adoption of the bioinformatics infrastructure philosophy by the national community. The…
View article: Transcriptome architecture and regulation at environmental transitions in flavobacteria: the case of an important fish pathogen
Transcriptome architecture and regulation at environmental transitions in flavobacteria: the case of an important fish pathogen Open
The family Flavobacteriaceae (phylum Bacteroidetes) is a major component of soil, marine and freshwater ecosystems. In this understudied family, Flavobacterium psychrophilum is a freshwater pathogen that infects salmonid fish worldwide, wi…
View article: Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome
Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome Open
View article: Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics Open
View article: Population-scale proteome variation in human induced pluripotent stem cells
Population-scale proteome variation in human induced pluripotent stem cells Open
Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA …
View article: Author response: Population-scale proteome variation in human induced pluripotent stem cells
Author response: Population-scale proteome variation in human induced pluripotent stem cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Human disease phenotypes are driven primar…
View article: Properties of structural variants and short tandem repeats associated with gene expression and complex traits
Properties of structural variants and short tandem repeats associated with gene expression and complex traits Open
View article: Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats
Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats Open
View article: Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome
Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome Open
Summary X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby genes from one X chromosome are repressed. Analysis of human induced pluripotent stem cell (iPSC) lines using proteomics, RNAseq and polys…
View article: hipsci_peptide_qtls
hipsci_peptide_qtls Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". peptideQTL (associations performed at peptide resolution using peptide intensities and aggregated at gene level) mapping pe…
View article: hipsci_eqtls_202_lines
hipsci_eqtls_202_lines Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". eQTL (RNA expression gene level) mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is organised as follow…
View article: hipsci_peptide_qtls
hipsci_peptide_qtls Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". peptideQTL (associations performed at peptide resolution using peptide intensities and aggregated at gene level) mapping pe…
View article: Erosion of Human X Chromosome Inactivation Causes Major Remodelling of the iPSC Proteome
Erosion of Human X Chromosome Inactivation Causes Major Remodelling of the iPSC Proteome Open
View article: hipsci_transcript_qtls_202_lines
hipsci_transcript_qtls_202_lines Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". transcriptQTL (RNA expression transcript level) mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is orga…
View article: hipsci_pqtls
hipsci_pqtls Open
Data corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells"This h5 file is organised as follows: feature_id chromosome start end [ensembl_gene_id] [feature_strand] [gene_name] [superior_f…
View article: hipsci_transcript_qtls_202_lines
hipsci_transcript_qtls_202_lines Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". transcriptQTL (RNA expression transcript level) mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is orga…
View article: hipsci_eqtls_202_lines
hipsci_eqtls_202_lines Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". eQTL (RNA expression gene level) mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is organised as follow…
View article: hipsci_pqtls
hipsci_pqtls Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". Protein QTL mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is organised as follows:| feature_id | + da…
View article: hipsci_peptide_qtls
hipsci_peptide_qtls Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". peptideQTL (associations performed at peptide resolution using peptide intensities and aggregated at gene level) mapping pe…
View article: hipsci_transcript_qtls_202_lines
hipsci_transcript_qtls_202_lines Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". transcriptQTL (RNA expression transcript level) mapping performed on GRCh37 using 202 IPS cell lines. This h5 file is orga…
View article: hipsci_peptide_qtls
hipsci_peptide_qtls Open
Dataset corresponding to the article "Population-scale proteome variation in human induced pluripotent stem cells". peptideQTL (associations performed at peptide resolution using peptide intensities and aggregated at gene level) mapping pe…
View article: Multi-omics Characterization of Interaction-mediated Control of Human Protein Abundance levels
Multi-omics Characterization of Interaction-mediated Control of Human Protein Abundance levels Open
View article: Multi-omics characterization of interaction-mediated control of human protein abundance levels
Multi-omics characterization of interaction-mediated control of human protein abundance levels Open
Proteogenomic studies of cancer samples have shown that copy number variation can be attenuated at the protein level, for a large fraction of the proteome, likely due to the degradation of unassembled protein complex subunits. Such interac…
View article: Population-scale proteome variation in human induced pluripotent stem cells
Population-scale proteome variation in human induced pluripotent stem cells Open
Realising the potential of human induced pluripotent stem cell (iPSC) technology for drug discovery, disease modelling and cell therapy requires an understanding of variability across iPSC lines. While previous studies have characterized i…