Bingliang Lin
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View article: Disulfiram/Copper Combination as a Potential Therapeutic Approach for Hepatocellular Carcinoma: Targeting the ATF3-Mitochondrial Cell Death Pathway
Disulfiram/Copper Combination as a Potential Therapeutic Approach for Hepatocellular Carcinoma: Targeting the ATF3-Mitochondrial Cell Death Pathway Open
View article: Machine learning model for HBsAg seroclearance after 48-week pegylated interferon therapy in inactive HBsAg carriers: a retrospective study
Machine learning model for HBsAg seroclearance after 48-week pegylated interferon therapy in inactive HBsAg carriers: a retrospective study Open
The RF-based model accurately predicts HBsAg clearance in IHC patients undergoing Peg-IFN therapy and offers a promising tool for early identification of candidates for individualized treatment strategies.
View article: Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial
Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial Open
Functional cure is a goal for the treatment of chronic hepatitis B virus (HBV) infection; however, it is infrequently achieved with currently approved treatments. Here we provide a randomized evaluation of the small interfering RNA elebsir…
View article: Chinese expert consensus on the combined use of antiviral drugs for influenza
Chinese expert consensus on the combined use of antiviral drugs for influenza Open
Influenza is an acute respiratory infectious disease caused by influenza viruses, and it poses a serious threat to global public health. High-risk groups include the elderly, infants and young children, pregnant women, and patients with ch…
View article: Impact of Pegylated Interferon Combined with Oral Antiviral Therapy on Liver Fibrosis in Patients with Chronic Hepatitis B: A 48-Week Prospective Cohort Study
Impact of Pegylated Interferon Combined with Oral Antiviral Therapy on Liver Fibrosis in Patients with Chronic Hepatitis B: A 48-Week Prospective Cohort Study Open
Background and Aims:Pegylated interferon (PEG-IFN) combined with oral antiviral agents is currently the most widely used and highly effective treatment regimen for chronic hepatitis B virus (HBV) infection. While effectively suppressing HB…
View article: Chinese expert consensus on the combined use of antiviral drugs for novel coronavirus infection
Chinese expert consensus on the combined use of antiviral drugs for novel coronavirus infection Open
The persistent mutation of the novel coronavirus (SARS-CoV-2) not only remains a threat to human health but also continues to challenge existing antiviral therapeutic strategies. In current clinical practice, the resistance of novel corona…
View article: Correction: Nucleos(t)ide analogs continuation is not associated with a lower risk of HBsAg seroreversion following PEG-IFN-induced HBsAg loss
Correction: Nucleos(t)ide analogs continuation is not associated with a lower risk of HBsAg seroreversion following PEG-IFN-induced HBsAg loss Open
View article: Current Situation and Prospects of Digital Therapeutics in the Field of Liver Diseases in China
Current Situation and Prospects of Digital Therapeutics in the Field of Liver Diseases in China Open
View article: Nucleos(t)ide analogs continuation is not associated with a lower risk of HBsAg seroreversion following PEG-IFN-induced HBsAg loss
Nucleos(t)ide analogs continuation is not associated with a lower risk of HBsAg seroreversion following PEG-IFN-induced HBsAg loss Open
View article: Impact of Pegylated Interferon Combined with Oral Antiviral Therapy on Liver Fibrosis in Patients with Chronic Hepatitis B: A 48-Week Prospective Cohort Study
Impact of Pegylated Interferon Combined with Oral Antiviral Therapy on Liver Fibrosis in Patients with Chronic Hepatitis B: A 48-Week Prospective Cohort Study Open
View article: The potential value of fatty acid binding protein 1 in Chronic HBV-related liver disease progression assessment
The potential value of fatty acid binding protein 1 in Chronic HBV-related liver disease progression assessment Open
View article: Interferon-α could induce liver steatosis to promote HBsAg loss by increasing triglyceride level
Interferon-α could induce liver steatosis to promote HBsAg loss by increasing triglyceride level Open
View article: CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis Open
Background The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This study aimed to inve…
View article: Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation Open
View article: Olgotrelvir as a Standalone Treatment for Nonhospitalized COVID-19 Patients (MPR-COV-301CN): A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial
Olgotrelvir as a Standalone Treatment for Nonhospitalized COVID-19 Patients (MPR-COV-301CN): A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial Open
View article: Leritrelvir for the treatment of mild or moderate COVID-19 without co-administered ritonavir: a multicentre randomised, double-blind, placebo-controlled phase 3 trial
Leritrelvir for the treatment of mild or moderate COVID-19 without co-administered ritonavir: a multicentre randomised, double-blind, placebo-controlled phase 3 trial Open
This study was funded by the National Multidisciplinary Innovation Team Project of Traditional Chinese Medicine, Guangdong Science and Technology Foundation, Guangzhou Science and Technology Planning Project and R&D Program of Guangzhou La…
View article: Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure Open
This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged…
View article: Single-cell Technologies Provide Novel Insights into Liver Physiology and Pathology
Single-cell Technologies Provide Novel Insights into Liver Physiology and Pathology Open
The liver is the largest glandular organ in the body and has a unique distribution of cells and biomolecules. However, the treatment outcome of end-stage liver disease is extremely poor. Single-cell sequencing is a new advanced and powerfu…
View article: Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote liver regeneration via miR-20a-5p/PTEN
Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote liver regeneration via miR-20a-5p/PTEN Open
Balancing hepatocyte death and proliferation is key to non-transplantation treatments for acute liver failure (ALF), which has a high short-term mortality rate. Small extracellular vesicles (sEVs) may act as mediators in the repair of dama…
View article: Predictive value of Th17 and Treg cells at baseline for HBsAg loss in chronic hepatitis B patients with low HBsAg quantification treated with pegylated interferon and nucleos(t)ide analogue
Predictive value of Th17 and Treg cells at baseline for HBsAg loss in chronic hepatitis B patients with low HBsAg quantification treated with pegylated interferon and nucleos(t)ide analogue Open
View article: Pulmonary Sparganosis Identified by Metagenomic Next-Generation Sequencing: A Case Report
Pulmonary Sparganosis Identified by Metagenomic Next-Generation Sequencing: A Case Report Open
View article: Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB
Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB Open
View article: Expert Consensus on the Prevention and Treatment of Hemorrhagic Fever with Renal Syndrome
Expert Consensus on the Prevention and Treatment of Hemorrhagic Fever with Renal Syndrome Open
Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonosis with a global distribution. China is one of the countries with a high incidence of HFRS, which has long endangered the lives and health of the Chinese people. The Infectious…
View article: The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study
The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study Open
View article: Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure Open
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of v…
View article: Rapid diagnosis of disseminated <i>Mycobacterium mucogenicum </i>infection in formalin-fixed, paraffin-embedded specimen using next-generation sequencing: A case report
Rapid diagnosis of disseminated <i>Mycobacterium mucogenicum </i>infection in formalin-fixed, paraffin-embedded specimen using next-generation sequencing: A case report Open
Next-generation sequencing is a promising tool for the rapid and accurate diagnosis of rare pathogens, even when using a formalin-fixed, paraffin-embedded specimen.
View article: Derivation and Validation of a Nomogram for Predicting 90-Day Survival in Patients With HBV-Related Acute-on-Chronic Liver Failure
Derivation and Validation of a Nomogram for Predicting 90-Day Survival in Patients With HBV-Related Acute-on-Chronic Liver Failure Open
Background: Conventional prognostic models do not fully reflect the severity of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). This study aimed to establish an effective and convenient nomogram for patients with HBV…
View article: Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19
Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19 Open
View article: Potential Networks Regulated by MSCs in Acute-On-Chronic Liver Failure: Exosomal miRNAs and Intracellular Target Genes
Potential Networks Regulated by MSCs in Acute-On-Chronic Liver Failure: Exosomal miRNAs and Intracellular Target Genes Open
Acute-on-chronic liver failure (ACLF) is a severe syndrome associated with high mortality. Alterations in the liver microenvironment are one of the vital causes of immune damage and liver dysfunction. Human bone marrow mesenchymal stem cel…
View article: Gut microbiota as prognosis markers for patients with HBV-related acute-on-chronic liver failure
Gut microbiota as prognosis markers for patients with HBV-related acute-on-chronic liver failure Open
The gut microbiota in the hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) is poorly defined. We aim to uncover the characteristics of the gut microbiota in HBV-ACLF and in other HBV associated pathologies. We analyzed t…