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View article: The impact of vascular endothelial growth factor on oral squamous cell carcinoma through dendritic cell induction and facilitation of tumor immune tolerance
The impact of vascular endothelial growth factor on oral squamous cell carcinoma through dendritic cell induction and facilitation of tumor immune tolerance Open
Our findings elucidate the crucial role of VEGF in OSCC progression by modulating DC function, offering new insights into potential immunotherapeutic strategies targeting VEGF-mediated pathways.
View article: Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets
Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets Open
Tissue repair represents a highly intricate and ordered dynamic process, critically reliant on the orchestration of immune cells. Among these, neutrophils, the most abundant leukocytes in the body, emerge as the initial immune responders a…
View article: Neutrophil Membrane‐Encapsulated Polymerized Salicylic Acid Nanoparticles Effectively Alleviating Rheumatoid Arthritis by Facilitating Sustained Release of Salicylic Acid into the Articular Cavity from Chondrocytes
Neutrophil Membrane‐Encapsulated Polymerized Salicylic Acid Nanoparticles Effectively Alleviating Rheumatoid Arthritis by Facilitating Sustained Release of Salicylic Acid into the Articular Cavity from Chondrocytes Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily instigates chronic inflammation in multiple joints. Salicylic acid (SA) is a classic anti‐inflammatory agent for the treatment of RA. To enhance the therapeutic effe…
View article: Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair
Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair Open
Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic ou…
View article: N2‐Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle
N2‐Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle Open
The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that intramuscular implantation of interleukin‐8 (IL‐8) (commonly recognized as a chemotactic cytokine for neutrophils) at different levels lead to ou…
View article: Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs Open
On-demand controlled miR-21-5p delivery system integrates immune modification and proangiogenesis assists MI therapy.
View article: NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence <i>via</i> the induction of ASCT2
NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence <i>via</i> the induction of ASCT2 Open
Background: Metastasis is the most common cause of lethal outcome in various types of cancers. Although the cell proliferation related metabolism rewiring has been well characterized, less is known about the association of metabolic change…
View article: Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)
Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review) Open
Epithelial‑mesenchymal transition (EMT) is required for the distant metastasis of tumors. The degree of tumor malignancy increases as EMT progresses. Notably, the biology of tumor cells differs from that of normal cells, with regards to ch…
View article: Nuclear Multidrug Resistance-Related Protein 1 Is Highly Associated with Better Prognosis of Human Mucoepidermoid Carcinoma through the Suppression of Cell Proliferation, Migration and Invasion
Nuclear Multidrug Resistance-Related Protein 1 Is Highly Associated with Better Prognosis of Human Mucoepidermoid Carcinoma through the Suppression of Cell Proliferation, Migration and Invasion Open
Our results suggested that nuclear MRP1 is highly associated with better prognosis of human mucoepidermoid carcinoma and further study of its function mechanism would provide clues in developing new treatment modalities of MEC.