Junhua Zhang
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View article: Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults
Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults Open
Background Brominated flame retardants (BFRs), widely applied in fire prevention, are persistent environmental pollutants. Accumulating evidence indicates that BFRs can trigger inflammatory responses in humans, potentially contributing to …
View article: Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes
Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes Open
Osteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis. Although the full pathophysiology of OA remained unclear,…
View article: Elucidation of anti-SARS-CoV-2 and anti-inflammatory bioactives in Qingyan Dropping Pills via integrated in silico screening and bioactivity validation
Elucidation of anti-SARS-CoV-2 and anti-inflammatory bioactives in Qingyan Dropping Pills via integrated in silico screening and bioactivity validation Open
Background The global outbreak of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised significant public health concerns. Qingyan Dropping Pills (QDP), as a recommended drug, i…
View article: Development and Validation of a Predictive Nomogram for Postpartum Hemorrhage in Pregnant Women: A Retrospective Study
Development and Validation of a Predictive Nomogram for Postpartum Hemorrhage in Pregnant Women: A Retrospective Study Open
This internally validated nomogram showed strong predictive performance for PPH using routinely collected clinical and psychosocial data. Future studies should conduct external validation and prospective multicenter evaluation to confirm i…
View article: Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems
Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems Open
Due to the concealed location of the nasopharynx, early diagnosis and treatment of nasopharyngeal carcinoma are relatively difficult. Although nasopharyngeal carcinoma is sensitive to radiation, normal tissues and organs are inevitably dam…
View article: Targeting SARS-CoV-2 main protease for the discovery of a broad-spectrum COVID-19 inhibitor by intensive multi-tiered validation
Targeting SARS-CoV-2 main protease for the discovery of a broad-spectrum COVID-19 inhibitor by intensive multi-tiered validation Open
SARS-CoV-2 and its emerging variants continue to pose a significant global public health threat. The SARS-CoV-2 main protease (Mpro) is a critical target for the development of antiviral agents that can inhibit viral replication and transc…
View article: Collaborative Mechanism of Soil and Water Ecological Governance Under Public–Private Partnership Model Considering Carbon Trading
Collaborative Mechanism of Soil and Water Ecological Governance Under Public–Private Partnership Model Considering Carbon Trading Open
In the current soil erosion control efforts, the lack of collaboration among multiple stakeholders is a major problem that restricts governance performance. Based on carbon trading and the Public–Private Partnership model, this paper const…
View article: Short-term post-COVID-19 symptoms in 21,012 patients: a cross-sectional study
Short-term post-COVID-19 symptoms in 21,012 patients: a cross-sectional study Open
Objectives: This study aimed to clarify the short-term symptoms, duration, and influencing factors in people recovering from coronavirus disease 2019 (COVID-19) after China’s dynamic zero-COVID-19 policy was implemented in December 2022. M…
View article: Prognostic Potential of Clinical Factors, Serological Indicators, and Pelvic Floor Ultrasound Parameters in Women With Postpartum Stress Urinary Incontinence
Prognostic Potential of Clinical Factors, Serological Indicators, and Pelvic Floor Ultrasound Parameters in Women With Postpartum Stress Urinary Incontinence Open
Aims/Background Numerous studies have assessed factors influencing stress urinary incontinence (SUI); however, their findings are somewhat inconsistent. Therefore, this study aimed to explore the predictive potential of clinical characteri…
View article: Xuanfei Baidu Formula Ameliorates Influenza A Virus-Induced Lung Inflammation by Repressing the NLRP3 Inflammasome in Macrophages
Xuanfei Baidu Formula Ameliorates Influenza A Virus-Induced Lung Inflammation by Repressing the NLRP3 Inflammasome in Macrophages Open
The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is an intracellular protein complex containing a nucleotide-binding oligomerization domain, leucine-rich repeats, and a pyrin domain. It is a key regulator…
View article: The pharmacology and mechanism of action of Monascus purpureus Went: a scoping review
The pharmacology and mechanism of action of Monascus purpureus Went: a scoping review Open
Objective The aim of this study is to review the recent studies on the pharmacology and mechanism of action of Monascus purpureus Went, analyze its medicinal value, and explore future research directions. Method A scoping review was conduc…
View article: Clinicopathological features and prognosis of non-HPV-associated adenocarcinoma
Clinicopathological features and prognosis of non-HPV-associated adenocarcinoma Open
Background: Owing to the rarity of non-HPV-associated adenocarcinoma, clinicopathological features and prognosis remain poorly understood. The aim of our study is to analyze clinicopathological features and prognosis of non-HPV-associated …
View article: From traditional medicine to modern medicine: the importance of TCM regulatory science (TCMRS) as an emerging discipline
From traditional medicine to modern medicine: the importance of TCM regulatory science (TCMRS) as an emerging discipline Open
Traditional Chinese medicine (TCM) has become a standardized medical system through systematic development across global healthcare practices. However, concerns persist regarding the safety, efficacy and quality of traditional medicinal pr…
View article: Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023)
Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023) Open
Objective: Randomized controlled trials (RCTs) of Chinese patent medicines and classic traditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023. A preliminary summary …
View article: Development status of core outcome sets in China: a protocol
Development status of core outcome sets in China: a protocol Open
Background Awareness of COS development and use among Chinese researchers has increased since the concept was introduced in China in 2012. An increasing number of COS have been registered and completed by Chinese developers. The status of …
View article: Large language models in traditional Chinese medicine: a systematic review
Large language models in traditional Chinese medicine: a systematic review Open
Objective: Generative artificial intelligence (AI) technology, represented by large language models (LLMs), has gradually been developed for traditional Chinese medicine (TCM); however, challenges remain in effectively enhancing AI applica…
View article: Modelling Arctic Lower Tropospheric Ozone: processes controlling seasonal variations
Modelling Arctic Lower Tropospheric Ozone: processes controlling seasonal variations Open
Previous assessments on modelling Arctic tropospheric ozone (O3) have shown that most atmospheric models continue to experience difficulties in simulating tropospheric O3 in the Arctic, particularly in capturing the seasonal variations at …
View article: The Low Friction Coefficient and High Wear Resistance UHMWPE: The Effect of Pores on Properties of Artificial Joint Materials
The Low Friction Coefficient and High Wear Resistance UHMWPE: The Effect of Pores on Properties of Artificial Joint Materials Open
Ultrahigh-molecular-weight-polyethylene (UHMWPE) is extensively applied to make bone and cartilage implants in the field of biomaterial application. UHMWPE matched with a metal or ceramic component withstands the long-term effect of cyclic…
View article: ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors
ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors Open
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor among the most lethal cancers. ARID1A has a dual role in oncogenic and tumor-suppressive functions, depending on the type of cancer. However, its role in SCLC remain…