Bolong Lin
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View article: A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity
A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity Open
Immune checkpoint blockade (ICB) therapies have emerged as promising treatment of cancer, but the efficacy is limited. NLRP3 inflammasome activation in tumor microenvironment can promote the infiltration of cytotoxic lymphocytes and antitu…
View article: An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups
An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups Open
NLRP3 inflammasome is involved in the pathology of multiple human inflammatory diseases but there are still no clinically available medications targeting the NLRP3 inflammasome. We have previously identified RRx-001 as a highly selective a…
View article: ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation Open
Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating NLRP3 inflammasome activation have been revealed, the checkpoints governing NLRP3 inflammasome activation remain…