Desheng Lu
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View article: The association of the Wnt/β-catenin signaling pathway with Alzheimer's disease
The association of the Wnt/β-catenin signaling pathway with Alzheimer's disease Open
With the global rise in population aging, the incidence of Alzheimer's disease (AD) continues to increase, posing a substantial burden on individuals, families, and healthcare systems. However, at present, the drugs approved by FDA for tre…
View article: Research Progress of Platinum-Based Complexes in Lung Cancer Treatment: Mechanisms, Applications, and Challenges
Research Progress of Platinum-Based Complexes in Lung Cancer Treatment: Mechanisms, Applications, and Challenges Open
Platinum-based complexes, as one of the mainstay chemotherapeutic agents in oncology, have evolved from first-generation Cisplatin to third-generation Oxaliplatin, with numerous platinum complexes currently under clinical investigation. Th…
View article: CK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells
CK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells Open
The dysregulation of Bcl-x alternative splicing is associated with tumor development and chemoresistance. However, the underlying molecular mechanisms of Bcl-x splicing are still not well-defined. Here, we demonstrated that casein kinase 1…
View article: Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma Open
Breast cancer stem-like cells (CSCs) are enriched following treatment with chemotherapy, and posited as having a high level of plasticity and enhanced tumor-initiation capacity, which can enable cancer relapse. Here, we show that such feat…
View article: Dialysis Modality Education Timing and Home Dialysis Uptake: A Quality Improvement Study
Dialysis Modality Education Timing and Home Dialysis Uptake: A Quality Improvement Study Open
We succeeded in boosting education rates but failed to achieve higher home dialysis choice rates, possibly owing to the complexity involved in modality choices. We plan to further investigate the factors influencing patient choices during …
View article: Identification of energy metabolism anomalies and serum biomarkers in the progression of premature ovarian failure via extracellular vesicles’ proteomic and metabolomic profiles
Identification of energy metabolism anomalies and serum biomarkers in the progression of premature ovarian failure via extracellular vesicles’ proteomic and metabolomic profiles Open
Omics analysis revealed that inflammation, oxidative stress, and hormone imbalance are factors that damage ovarian tissue, but the progressive dysfunction of energy metabolism might be the critical pathogenic pathway contributing to the de…
View article: Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity Open
The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway …
View article: The <scp>CK</scp> 1ε/ <scp>SIAH1</scp> axis regulates <scp>AXIN</scp> 1 stability in colorectal cancer cells
The <span>CK</span> 1ε/ <span>SIAH1</span> axis regulates <span>AXIN</span> 1 stability in colorectal cancer cells Open
Casein kinase 1ε (CK1ε) and axis inhibitor 1 (AXIN1) are crucial components of the β‐catenin destruction complex in canonical Wnt signaling. CK1ε has been shown to interact with AXIN1, but its physiological function and role in tumorigenes…
View article: A PANoptosis pattern to predict prognosis and immunotherapy response in head and neck squamous cell carcinoma
A PANoptosis pattern to predict prognosis and immunotherapy response in head and neck squamous cell carcinoma Open
Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) experience a significant occurrence rate and are susceptible to premature spreading, resulting in a bleak outlook. Therapeutic approaches, such as chemotherapy, targe…
View article: R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis
R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis Open
R-spondins (RSPOs) are secreted signaling molecules that potentiate the Wnt/β-catenin pathway by cooperating with Wnt ligands. RSPO1 is crucial in tissue development and tissue homeostasis. However, the molecular mechanism by which RSPOs a…
View article: Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer Open
Chloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the ef…
View article: R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis
R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis Open
R-spondins (RSPOs) are secreted signaling molecules that potentiate the Wnt/β-catenin pathway by cooperating with Wnt ligands. However, the molecular mechanism by which RSPOs activate Wnt/β-catenin signaling remains elusive. In this study,…
View article: YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia
YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia Open
Y-box-binding protein 1 (YBX1), a member of the RNA-binding protein family, is a critical regulator of cell survival in various solid tumors and acute myeloid leukemia. However, the function of YBX1 in T-cell acute lymphoblastic leukemia (…
View article: <scp>WDR54</scp> exerts oncogenic roles in T‐cell acute lymphoblastic leukemia
<span>WDR54</span> exerts oncogenic roles in T‐cell acute lymphoblastic leukemia Open
WDR54 has been recently identified as a novel oncogene in colorectal and bladder cancers. However, the expression and function of WDR54 in T‐cell acute lymphoblastic leukemia (T‐ALL) were not reported. In this study, we investigated the ex…
View article: The analysis of cathepsin L that mediates cellular SARS‐CoV‐2 infection leading to COVID‐19 in head and neck squamous cell carcinoma
The analysis of cathepsin L that mediates cellular SARS‐CoV‐2 infection leading to COVID‐19 in head and neck squamous cell carcinoma Open
The vulnerability of the oral cavity to SARS-CoV-2 infection is well-known, and cancer patients are at a higher risk of COVID-19, emphasizing the need to prioritize this patient population. Head and neck squamous cell carcinoma (HNSCC) is …
View article: YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling
YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling Open
Many efforts are underway to improve immune checkpoint blockade (ICB) therapy including potentiating MHC-I antigen processing and presentation. Accumulating evidence links the Hippo pathway to immunotherapy response, but the understanding …
View article: ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth Open
Background and Purpose: ISX9 is a neurogenesis-promoting small molecule compound which can upregulate the expression of NeuroD1 and induce differentiation of neuronal, cardiac and islet endocrine progenitors. So far, the molecular mechanis…
View article: The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer
The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer Open
Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear. In th…
View article: CCDC 1550486: Experimental Crystal Structure Determination
CCDC 1550486: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1550487: Experimental Crystal Structure Determination
CCDC 1550487: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer
The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer Open
Background: Amino-terminal enhancer of split (AES) has been identified as a tumor and metastasis suppressor in some cancers including colorectal cancer (CRC), but very little is known about the regulation of AES expression. Methods: Bioinf…
View article: A Multi-Gene Model Effectively Predicts the Overall Prognosis of Stomach Adenocarcinomas With Large Genetic Heterogeneity Using Somatic Mutation Features
A Multi-Gene Model Effectively Predicts the Overall Prognosis of Stomach Adenocarcinomas With Large Genetic Heterogeneity Using Somatic Mutation Features Open
The study made a systematic analysis on the association between STAD prognosis and somatic mutations, identified signature genes that showed mutation preference in different prognostic groups, and developed an effective multi-gene model th…
View article: Improving the diversity of captured full-length isoforms using a normalized single-molecule RNA-sequencing method
Improving the diversity of captured full-length isoforms using a normalized single-molecule RNA-sequencing method Open
Human genes form a large variety of isoforms after transcription, encoding distinct transcripts to exert different functions. Single-molecule RNA sequencing facilitates accurate identification of the isoforms by extending nucleotide read l…
View article: Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity
Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity Open
Aberrant activation of Wnt signaling plays a critical role in the initiation and progression of colorectal cancer (CRC). Chlorquinaldol (CQD) is a topical antimicrobial agent used to treat skin infections. Little is known about the antican…