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View article: Implementation outcomes from the Hypertension Treatment in Nigeria program: results from a type 2 hybrid interrupted time series trial
Implementation outcomes from the Hypertension Treatment in Nigeria program: results from a type 2 hybrid interrupted time series trial Open
Background The Hypertension Treatment in Nigeria Program was implemented across 60 primary healthcare centers (PHCs) in Nigeria to improve hypertension treatment and control using the World Health Organization’s HEARTS package. This study …
View article: Early structural cardiovascular disease, HIV, and tuberculosis in East Africa (ASANTE): cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya
Early structural cardiovascular disease, HIV, and tuberculosis in East Africa (ASANTE): cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya Open
Introduction Persons living with HIV (PLWH) have an augmented risk of cardiovascular disease, including atherosclerosis and myocardial dysfunction, despite effective viral suppression with antiretroviral therapy. Despite the majority of PL…
View article: Climate, health, and living condition crises in the expanding informal settlements and slums of South-West Nigeria: a case report of Ogun and Oyo states
Climate, health, and living condition crises in the expanding informal settlements and slums of South-West Nigeria: a case report of Ogun and Oyo states Open
The rapid expansion of informal settlements and slums in southwestern Nigeria, particularly along the Lagos-Ogun-Oyo corridor, underscores the critical challenges posed by rapid urbanisation and population growth in this major economic hub…
View article: Prevalence and Associated Factors of Overweight and Obesity Among People Living with HIV/AIDS on Antiretroviral Therapy in Benin’s National Teaching Hospital
Prevalence and Associated Factors of Overweight and Obesity Among People Living with HIV/AIDS on Antiretroviral Therapy in Benin’s National Teaching Hospital Open
Overweight and obesity are major global public health concerns. Understanding their relationship with lifestyle factors in the context of HIV is crucial to improving health outcomes. This study aimed to determine the prevalence and associa…
View article: Early Structural Cardiovascular Disease, HIV, and Tuberculosis in East Africa (ASANTE): Cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya
Early Structural Cardiovascular Disease, HIV, and Tuberculosis in East Africa (ASANTE): Cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya Open
Introduction Persons living with HIV (PLWH) have an augmented risk of cardiovascular disease, including atherosclerosis and myocardial dysfunction, despite effective viral suppression with antiretroviral therapy (ART). Despite the majority…
View article: Exploring the impact of climate change on respiratory health in Nigeria: a scoping review of current research, government policies and programs
Exploring the impact of climate change on respiratory health in Nigeria: a scoping review of current research, government policies and programs Open
Climate change significantly impacts health globally, especially in densely populated, rapidly industrialising and ecologically diverse countries like Nigeria. We analysed climate change policies, studies, programs, and events at the natio…
View article: Stakeholders' perspectives on addressing climate change and respiratory health impacts in Nigeria
Stakeholders' perspectives on addressing climate change and respiratory health impacts in Nigeria Open
The impacts of climate change on respiratory health are increasingly becoming a significant challenge in Nigerian cities, particularly in Lagos and Ogun States. Engaging stakeholders in discussions about climate change and health is crucia…
View article: Supportive supervision visits in a large community hypertension programme in Nigeria: implementation methods and outcomes
Supportive supervision visits in a large community hypertension programme in Nigeria: implementation methods and outcomes Open
Background The Hypertension Treatment in Nigeria (HTN) Programme established a system for hypertension diagnosis and management in 60 public primary healthcare facilities in the Federal Capital Territory of Nigeria through the implementati…
View article: Low Prevalence of Coronary Artery Calcium in High Cardiometabolic Risk Kenyan Adults with and Without HIV: The ASANTE Study
Low Prevalence of Coronary Artery Calcium in High Cardiometabolic Risk Kenyan Adults with and Without HIV: The ASANTE Study Open
View article: Effects of a Pragmatic Type 2 Hybrid Interrupted Time Series Trial on Hypertension Treatment and Control in Nigeria
Effects of a Pragmatic Type 2 Hybrid Interrupted Time Series Trial on Hypertension Treatment and Control in Nigeria Open
The burden of hypertension is large and rapidly rising in Nigeria. We sought to implement and evaluate a large-scale hypertension treatment and control program, adapted from the Kaiser Permanente Northern California and World Health Organi…
View article: Promotion of Cardiovascular Health in Africa
Promotion of Cardiovascular Health in Africa Open
View article: Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial
Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial Open
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics …
View article: Barriers to global engagement for African researchers: A position paper from the Alliance for Medical Research in Africa (AMedRA)
Barriers to global engagement for African researchers: A position paper from the Alliance for Medical Research in Africa (AMedRA) Open
International audience
View article: Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases
Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases Open
Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck's Ervebo (rVSV-ZEBOV) and Johnson & Johnson's two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in …
View article: Prevalence and associated factors of hypertension among people living with HIV/AIDS on antiretroviral therapy in Benin’s National Teaching Hospital
Prevalence and associated factors of hypertension among people living with HIV/AIDS on antiretroviral therapy in Benin’s National Teaching Hospital Open
View article: Exploring Hidden Markov Models in the Context of Genetic Disorders, and Related Conditions: A Systematic Review
Exploring Hidden Markov Models in the Context of Genetic Disorders, and Related Conditions: A Systematic Review Open
The application of Hidden Markov Models (HMMs) in the study of genetic and neurological disorders has shown significant potential in advancing our understanding and treatment of these conditions. This review assesses 77 papers selected fro…
View article: Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis
Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis Open
Background Streptococcus pneumoniae (Spn) has been a leading cause of bacterial meningitis in children. The most recent estimation of the global burden of Spn meningitis indicates a positive trajectory in eliminating Spn through the implem…
View article: Estimated health benefits, costs and cost-effectiveness of eliminating industrial trans<i>-</i>fatty acids in Nigeria: cost-effectiveness analysis
Estimated health benefits, costs and cost-effectiveness of eliminating industrial trans<i>-</i>fatty acids in Nigeria: cost-effectiveness analysis Open
Introduction Nigeria is committed to reducing industrial trans- fatty acids (iTFA) from the food supply, but the potential health gains, costs and cost-effectiveness are unknown. Methods The effect on ischaemic heart disease (IHD) burden, …
View article: Markov modeling on dynamic state space for genetic disorders and infectious diseases with mutations: Probabilistic framework, parameter estimation, and applications
Markov modeling on dynamic state space for genetic disorders and infectious diseases with mutations: Probabilistic framework, parameter estimation, and applications Open
The emergence and dynamic prevalence of genetic disorders and infectious diseases with mutations pose significant challenges for public health interventions. This study investigated the parameter estimation approach and the application of …
View article: Effects of a Pragmatic Type 2 Hybrid Interrupted Time Series Trial on Hypertension Treatment and Control in Nigeria
Effects of a Pragmatic Type 2 Hybrid Interrupted Time Series Trial on Hypertension Treatment and Control in Nigeria Open
View article: Immunogenicity and Vaccine Shedding After 1 or 2 Doses of rVSVΔG-ZEBOV-GP Ebola Vaccine (ERVEBO®): Results From a Phase 2, Randomized, Placebo-controlled Trial in Children and Adults
Immunogenicity and Vaccine Shedding After 1 or 2 Doses of rVSVΔG-ZEBOV-GP Ebola Vaccine (ERVEBO®): Results From a Phase 2, Randomized, Placebo-controlled Trial in Children and Adults Open
Background The rVSVΔG-ZEBOV-GP vaccine (ERVEBO®) is a single-dose, live-attenuated, recombinant vesicular stomatitis virus vaccine indicated for the prevention of Ebola virus disease (EVD) caused by Zaire ebolavirus in individuals 12 month…
View article: Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone
Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone Open
View article: Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis (Preprint)
Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis (Preprint) Open
BACKGROUND Streptococcus pneumoniae (Spn) has been a leading cause of bacterial meningitis in children. The most recent estimation of the global burden of Spn meningitis indicates a positive trajectory in eliminating Spn through th…
View article: Abstract P223: Estimated Health Benefits, Costs, and Cost-Effectiveness of Eliminating Industrial Trans-Fatty Acids in Nigeria
Abstract P223: Estimated Health Benefits, Costs, and Cost-Effectiveness of Eliminating Industrial Trans-Fatty Acids in Nigeria Open
Objectives: To estimate the potential health gains, costs, and cost-effectiveness of a mandatory limit on industrial trans fatty acids (iTFA) in the Nigerian food supply. Methods: We used Markov cohort models to estimate the effect on isch…
View article: Presence of trans-Fatty Acids Containing Ingredients in Pre-Packaged Foods and the Availability of Reported trans-Fat Levels in Kenya and Nigeria
Presence of trans-Fatty Acids Containing Ingredients in Pre-Packaged Foods and the Availability of Reported trans-Fat Levels in Kenya and Nigeria Open
In most African countries, the prevalence of industrially produced trans-fatty acids (iTFA) in the food supply is unknown. We estimated the number and proportion of products containing specific (any hydrogenated edible oils) and non-specif…
View article: Fixed‐dose combination therapy‐based protocol compared with free pill combination protocol: Results of a cluster randomized trial
Fixed‐dose combination therapy‐based protocol compared with free pill combination protocol: Results of a cluster randomized trial Open
Fixed‐dose combination (FDC) therapy is recommended for hypertension management in Nigeria based on randomized trials at the individual level. This cluster‐randomized trial evaluates effectiveness and safety of a treatment protocol that us…
View article: Front-of-pack labeling: a health literacy intervention to improve cardiovascular health in Sub-Saharan Africa
Front-of-pack labeling: a health literacy intervention to improve cardiovascular health in Sub-Saharan Africa Open
There is a surge in the burden of cardiovascular disease (CVD) in Sub-Saharan African (SSA) countries. Over the last 50 years there has been a rapid growth in the consumption of ultra-processed food products high in salt, fat, and glycemic…
View article: Estimating the prevalence of COPD in an African country: evidence from southern Nigeria
Estimating the prevalence of COPD in an African country: evidence from southern Nigeria Open
Background Though several environmental and demographic factors would suggest a high burden of chronic obstructive pulmonary disease (COPD) in many African countries, there is insufficient country-level synthesis to guide public health pol…
View article: Characteristics and Patterns of Retention in Hypertension Care in Primary Care Settings From the Hypertension Treatment in Nigeria Program
Characteristics and Patterns of Retention in Hypertension Care in Primary Care Settings From the Hypertension Treatment in Nigeria Program Open
The findings suggest that retention in hypertension care is suboptimal in primary health care centers in Nigeria, although large variability among sites was found. Potentially modifiable and nonmodifiable factors associated with retention …
View article: Hypertension Treatment in Nigeria (HTN) Program: rationale and design for a type 2 hybrid, effectiveness, and implementation interrupted time series trial
Hypertension Treatment in Nigeria (HTN) Program: rationale and design for a type 2 hybrid, effectiveness, and implementation interrupted time series trial Open