Bo Zhang
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View article: Clinical significance of androgen receptor in unilateral invasive breast cancer in women
Clinical significance of androgen receptor in unilateral invasive breast cancer in women Open
View article: OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery
OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery Open
Therapeutic target discovery remains a critical yet intuition-driven bottleneck in drug develo ment, typically relying on disease biologists to laboriously integrate diverse biomedical data into testable hypotheses for experimental validat…
View article: Metabolomic machine learning-based model predicts efficacy of chemoimmunotherapy for advanced lung squamous cell carcinoma
Metabolomic machine learning-based model predicts efficacy of chemoimmunotherapy for advanced lung squamous cell carcinoma Open
Background Unlike lung adenocarcinoma, patients with advanced squamous carcinoma exhibit a low proportion of driver gene positivity, with fewer effective treatment strategies available. Chemoimmunotherapy has now become the standard first-…
View article: Perioperative chemotherapy for gastric cancer patients with microsatellite instability or deficient mismatch repair: A systematic review and meta‐analysis
Perioperative chemotherapy for gastric cancer patients with microsatellite instability or deficient mismatch repair: A systematic review and meta‐analysis Open
Background The efficacy of perioperative chemotherapy for deficient mismatch repair or microsatellite instability–high (dMMR/MSI‐H) gastric cancer (GC) remains controversial. Methods This study was preregistered with the PROSPERO platform …
View article: Chain of Ideas: Revolutionizing Research Via Novel Idea Development with LLM Agents
Chain of Ideas: Revolutionizing Research Via Novel Idea Development with LLM Agents Open
View article: Chain of Ideas: Revolutionizing Research Via Novel Idea Development with LLM Agents
Chain of Ideas: Revolutionizing Research Via Novel Idea Development with LLM Agents Open
Effective research ideation is a critical step for scientific research. However, the exponential increase in scientific literature makes it challenging for researchers to stay current with recent advances and identify meaningful research d…
View article: Case Report: Laparoscopy-assisted resection for intra-abdominal gossypiboma masquerading as a jejunal tumor (with video)
Case Report: Laparoscopy-assisted resection for intra-abdominal gossypiboma masquerading as a jejunal tumor (with video) Open
Introduction Intra-abdominal gossypiboma, a cotton-based retained foreign body after an abdominal surgery, is associated with various clinical manifestations and complications. Its infrequent occurrence and unpredictability make its early …
View article: Methodological quality of radiomic-based prognostic studies in gastric cancer: a cross-sectional study
Methodological quality of radiomic-based prognostic studies in gastric cancer: a cross-sectional study Open
Background Machine learning radiomics models are increasingly being used to predict gastric cancer prognoses. However, the methodological quality of these models has not been evaluated. Therefore, this study aimed to evaluate the methodolo…
View article: Case Report: Giant abdominal hemangioma originating from the liver
Case Report: Giant abdominal hemangioma originating from the liver Open
Background Hepatic hemangioma is among the most common benign liver lesions. However, giant pedunculated hepatic hemangiomas are exceptionally rare and associated with additional risks, such as torsion. Case presentation We present the cas…
View article: P-264 The effect of preoperative imatinib therapy in gastrointestinal stromal tumors: A multicenter study
P-264 The effect of preoperative imatinib therapy in gastrointestinal stromal tumors: A multicenter study Open
View article: Computed Tomography Angiography (CTA) Features of Aortic Floating Thrombus: Five Case Reports and Literature Review
Computed Tomography Angiography (CTA) Features of Aortic Floating Thrombus: Five Case Reports and Literature Review Open
: Aortic floating thrombus (AFT) is a rare disease, which is often misdiagnosed as a tumor or another disease. Here, we report five cases of AFT, confirmed by computed tomography angiography (CTA). The patients’ laboratory biomarkers, clin…
View article: Insight into gastrointestinal heterotopic pancreas: imaging evaluation and differential diagnosis
Insight into gastrointestinal heterotopic pancreas: imaging evaluation and differential diagnosis Open
View article: A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression
A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression Open
As a member of the phospholipase family, phospholipase C beta 1 (PLCB1) is involved in phospholipid hydrolysis and is frequently upregulated in human cancer. However, little is known about the role of PLCB1 in cholangiocarcinoma (CCA). In …
View article: Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum)
Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum) Open
Kava (Piper methysticum Forst) is a popular and favorable edible medicinal herb which was traditionally used to prepare a nonfermented beverage with relaxant beneficial for both social and recreational purposes. Numerous studies conducted …
View article: Protective Effect of Patchouli Alcohol Against SH-SY5Y Cell Injury Induced by Aβ<sub>25-35</sub> via the Reduction of Oxidative Stress and Apoptosis
Protective Effect of Patchouli Alcohol Against SH-SY5Y Cell Injury Induced by Aβ<sub>25-35</sub> via the Reduction of Oxidative Stress and Apoptosis Open
Patchouli alcohol (PA) has multiple pharmacological activities, but its protective effect against SH-SY5Y cell injury induced by Aβ 25-35 has not been reported. It has been recorded that phosphatidylinositol 3-hydroxykinase (PI3K)/protein …
View article: Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis
Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis Open
The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP) can reflect systemic inflammation and nutritional status simultaneously, with some evidence revealing its prognostic value for some tumors. However, the effect of H…
View article: Closure of Petersen’s defect in gastrectomy for gastric cancer: an interrupted time series analysis from a high-volume institution in China
Closure of Petersen’s defect in gastrectomy for gastric cancer: an interrupted time series analysis from a high-volume institution in China Open
Purpose Petersen’s hernia (PH) is a serious complication after gastrectomy for gastric cancer. The aim of this study was to investigate whether closure of Petersen’s defect (PD) can decrease the rates of PH and suspected Petersen’s hernia …
View article: TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats Open
Bin Han1 ,* Zijie Pei2 ,* Lei Shi,3 Qian Wang,4 Chen Li,1 Boyuan Zhang,1 Xuan Su,1 Ning Zhang,1 Lixiao Zhou,1 Bo Zhao,5 Yujie Niu,3,6 Rong Zhang1,6 1Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People&…
View article: N‑acetyl cysteine inhibits the lipopolysaccharide‑induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL‑1β signaling pathway
N‑acetyl cysteine inhibits the lipopolysaccharide‑induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL‑1β signaling pathway Open
N-acetyl cysteine (NAC) has been used to inhibit lipopolysaccharide (LPS)-induced inflammation. However, the molecular mechanism underlying its anti‑inflammatory effects remains to be elucidated. The present study aimed to determine the ef…
View article: Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway
Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway Open
Liver fibrosis, a chronic damage process related to further progression of hepatic cirrhosis, has yet no truly effective treatment. Isochlorogenic acid A (ICQA), isolated from a traditional Chinese herbal medicine named Laggera alata
View article: Preoperative hypoxemia in patients with type A acute aortic dissection: a retrospective study on incidence, related factors and clinical significance
Preoperative hypoxemia in patients with type A acute aortic dissection: a retrospective study on incidence, related factors and clinical significance Open
AAD patients were easy to have pre-operative HO, which had a higher morbidity than those without HO. Altered fibrinogen, WBC, systolic blood pressure levels, positive smoking history, and pleural effusion were associated with the presence …
View article: Anti-Osteoporotic Activity of an Edible Traditional Chinese Medicine Cistanche deserticola on Bone Metabolism of Ovariectomized Rats Through RANKL/RANK/TRAF6-Mediated Signaling Pathways
Anti-Osteoporotic Activity of an Edible Traditional Chinese Medicine Cistanche deserticola on Bone Metabolism of Ovariectomized Rats Through RANKL/RANK/TRAF6-Mediated Signaling Pathways Open
Given the limitations of existing therapeutic agents for treatment of postmenopausal osteoporosis, there still remains a need for more options with both efficacy and less adverse effects. Cistanche deserticola Y. C. Ma is known as a…
View article: Pediatric high-grade glioma resources from the Children’s Brain Tumor Tissue Consortium
Pediatric high-grade glioma resources from the Children’s Brain Tumor Tissue Consortium Open
View article: Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from <i>Cistanche deserticola</i> on Bone Microstructure in Ovariectomized Rats
Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from <i>Cistanche deserticola</i> on Bone Microstructure in Ovariectomized Rats Open
The present study was designed to estimate the antiosteoporotic activity of total phenylethanoid glycoside fraction isolated from C. deserticola (CDP) on rats induced by ovariectomy (OVX) as well as the related mechanisms. After 3 months o…
View article: Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)
Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA) Open
Background Pediatric high grade glioma (pHGG) remains a fatal disease. Increased access to richly annotated biospecimens and patient derived tumor models will accelerate pHGG research and support translation of research discoveries. This w…
View article: Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway
Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway Open
View article: Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders
Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders Open
Echinacoside (ECH), a natural phenylethanoid glycoside, was first isolated from Echinacea angustifolia DC. (Compositae) sixty years ago. It was found to possess numerous pharmacologically beneficial activities for human health, especially …
View article: Dynamic MR imaging for functional vascularization depends on tissue factor signaling in glioblastoma
Dynamic MR imaging for functional vascularization depends on tissue factor signaling in glioblastoma Open
Glomeruloid vascular proliferation (GVP) is a diagnostic hallmark and links to aggressive behavior, therapy resistance and poor prognosis in glioblastoma (GBM). It lacks clinical approaches to predict and monitor its formation and dynamic …
View article: Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation
Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation Open
Silybin is one of the main flavonoids produced by milk thistle, which has been used in the treatment of liver diseases. In this study, we examined the protective effects and possible mechanisms of action of silybin in lipopolysaccharide (L…
View article: MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer
MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer Open
PTEN is one of the direct target genes of miR-21. Thus, phosphatase gene and its downstream AKT and PI3K expression levels can be regulated by regulating the expression levels of miR-21, which in turn regulates the development of CRC.