Explanipedia

On the influence of tissue anisotropy in numerical modelling of radiofrequency ablation Open

Romain Fichter, Damijan Miklavčič, Bor Kos · 2025

Complexity and Perplexity of Pulsed Field Ablation: An Engineering Perspective Open

Bor Kos, Matej Reberšek, Damijan Miklavčič · 2025

Pulsed field ablation (PFA), recently introduced as a non-thermal and selective method for cardiac ablation, was associated with great promise, hope and expectation, but also raised some concerns and left some questions unanswered, in part…

Modified Unipolar Return Pulsed Field Ablation in Ventricular Myocardium Open

María Terricabras, Peter Lombergar, Terenz Escartin, Bor Kos, Philippa Krahn , et al. · 2025

BACKGROUND: Various pulsed field ablation (PFA) parameters have been proposed to improve lesion depth. This study evaluated a modified unipolar return PFA system to create deep lesions in healthy and infarcted ventricular myocardia. METHOD…

Neutronics analyses for EU-DEMO 2023 electron cyclotron port Open

Aljaž Čufar, Bor Kos, D. Leichtle, P. Spaeh · 2025

Biophysics and electrophysiology of pulsed field ablation in normal and infarcted porcine cardiac ventricular tissue Open

Damijan Miklavčič, Atul Kumar, Philippa Krahn, Jernej Štublar, Bor Kos , et al. · 2024

Pulsed Field Ablation (PFA) is a new ablation method being rapidly adopted for treatment of atrial fibrillation, which shows advantages in safety and efficiency over radiofrequency and cryo-ablation. In this study, we used an in vivo swine…

Elucidating the mechanisms of microbubble formation in intracardiac pulsed field ablation Open

Samo Mahnič-Kalamiza, Damijan Miklavčič, Peter Lombergar, Blaž Mikuž, Lars M. Mattison , et al. · 2024

Delivery of electrical energy for sensing or therapeutic purposes often involves electrochemical phenomena at the electrode-electrolyte solution interface. Release of gaseous bubbles that accompanies delivery of pulsed electric fields to t…

Genetically engineered HEK cells as a valuable tool for studying electroporation in excitable cells Open

Tina Batista Napotnik, Bor Kos, Tomaž Jarm, Damijan Miklavčič, Rodney P. O’Connor , et al. · 2024

From CAD to Nuclear Data S/U for Shielding Applications Open

Bor Kos, Bob Grove, Ivan Kodeli · 2024

Determination of lethal electric field threshold for pulsed field ablation in ex vivo perfused porcine and human hearts Open

Bor Kos, Lars M. Mattison, David A. Ramirez, Helena Cindrič, Daniel C. Sigg , et al. · 2023

Introduction Pulsed field ablation is an emerging modality for catheter-based cardiac ablation. The main mechanism of action is irreversible electroporation (IRE), a threshold-based phenomenon in which cells die after exposure to intense p…

PO-03-039 INVESTIGATION OF PULSED FIELD AND RADIOFREQUENCY ABLATION LESION DEPTH IN THE INFARCTED PORCINE LV Open

Philippa Krahn, Peter Lombergar, Bor Kos, Maria Terricabras Casas, Terenz Escartin , et al. · 2023

PO-03-089 COMPARING RADIOFREQUENCY ABLATION (RFA) AND PULSED FIELD ABLATION (PFA) SCAR HOMOGENIZATION IN A CHRONIC SWINE MODEL OF INFARCTION USING 3D LATE GADOLINIUM ENHANCEMENT (LGE) MRI Open

Terenz Escartin, Maria Terricabras Casas, Philippa Krahn, Jennifer Barry, Melissa Larsen , et al. · 2023

Optimization of Transpedicular Electrode Insertion for Electroporation-Based Treatments of Vertebral Tumors Open

Helena Cindrič, Damijan Miklavčič, F. Cornélis, Bor Kos · 2022

Electroporation-based treatments such as electrochemotherapy and irreversible electroporation ablation have sparked interest with respect to their use in medicine. Treatment planning involves determining the best possible electrode positio…

Effects of Electrode-Tissue Proximity on Cardiac Lesion Formation Using Pulsed Field Ablation Open

Brian Howard, Atul Verma, Wendy S. Tzou, Lars M. Mattison, Bor Kos , et al. · 2022

Background: Pulsed field ablation (PFA) is a novel energy modality for treatment of cardiac arrhythmias. The impact of electrode-tissue proximity on lesion formation by PFA has not been conclusively assessed. The objective of this investig…

Numerical mesoscale tissue model of electrochemotherapy in liver based on histological findings Open

Helena Cindrič, Gorana Gašljević, Ibrahim Edhemović, Erik Brecelj, Jan Žmuc , et al. · 2022

Optimization of transpedicular electrode insertion for electro-poration-based treatments of spinal tumors Open

Helena Cindrič, Damijan Miklavčič, F. Cornélis, Bor Kos · 2022

The dataset (models.zip) contains 36 COMSOL Multiphysics files (.mph file extension) containing anatomically realistic models of single vertebrae with spherical tumors in the vertebral body. The models are prepared for simulation of electr…

Neutron Flux Distributions for ITER B1 Port Cell 16 Shielding Design Open

Kara Godsey, Bor Kos, Mathew Swinney · 2022

Effect of Shielding Homogenization on Neutronics of ITER EP Plugs Open

Bor Kos, M. Messineo, Tara Pandya, Brian McAllister Linn, Allan Basile · 2022

Safety and chronic lesion characterization of pulsed field ablation in a Porcine model Open

Mark T. Stewart, David E. Haines, Damijan Miklavčič, Bor Kos, Nicole Kirchhof , et al. · 2021

Background Pulsed field ablation (PFA) has been identified as an alternative to thermal‐based ablation systems for treatment of atrial fibrillation patients. The objective of this Good Laboratory Practice (GLP) study was to characterize th…

Ireverzibilna elektroporacija kot metoda ablacije mehkih tkiv: pregled in izzivi pri uporabi v kliničnem okolju Open

Helena Cindrič, Bor Kos, Damijan Miklavčič · 2021

Koncept ireverzibilne elektroporacije kot samostojne ablacijske metode je bil prvič predstavljen pred petnajstimi leti. Ireverzibilna elektroporacija predstavlja alternativo uveljavljenim termičnim ablacijskim metodam, saj mehanizem uničev…

Retrospective study for validation and improvement of numerical treatment planning of irreversible electroporation ablation for treatment of liver tumors Open

Helena Cindrič, Panchatcharam Mariappan, Lukas Philipp Beyer, Philipp Wiggermann, Michael Moche , et al. · 2021

Supplementary data for 18 cases of hepatic tumors, treated with percutaneous irreversible electroporation ablation.- segmentation.nii (NIfTI format):Tissue masks, segmented from pre-interventional CECT. - liver_interv.vtk (VTK format):Live…

A Prospective Phase II Study Evaluating Intraoperative Electrochemotherapy of Hepatocellular Carcinoma Open

Mihajlo Djokić, Maja Čemažar, Maša Bošnjak, Rok Dežman, David Badovinac , et al. · 2020

The aim of this clinical study was to investigate the effectiveness and long-term safety of electrochemotherapy as an emerging treatment for HCC in patients not suitable for other treatment options. A prospective phase II clinical study wa…

Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers Open

Tomaž Jarm, Tadej Krmac, Ratko Magjarević, Bor Kos, Helena Cindrič , et al. · 2020

Background The effectiveness of electrochemotherapy of tumors (ECT) and of irreversible electroporation ablation (IRE) depends on different mechanisms and delivery protocols. Both therapies exploit the phenomenon of electroporation of the …

Safety and Feasibility of Electrochemotherapy of the Pancreas in a Porcine Model Open

Rok Dežman, Maja Čemažar, Gregor Serša, Alenka Seliškar, Vladimira Erjavec , et al. · 2020

Objectives The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an establi…

Percutaneous image guided electrochemotherapy of hepatocellular carcinoma: technological advancement Open

Mihajlo Djokić, Rok Dežman, Maja Čemažar, Miha Štabuc, Miha Petrič , et al. · 2020

Background Electrochemotherapy is an effective treatment of colorectal liver metastases and hepatocellular carcinoma (HCC) during open surgery. The minimally invasive percutaneous approach of electrochemotherapy has already been performed …

Intraoperative electrochemotherapy of colorectal liver metastases: A prospective phase II study Open

Ibrahim Edhemović, Erik Brecelj, Maja Čemažar, Nina Boc, Blaž Trotovšek , et al. · 2020

Electrochemotherapy has proven to be safe and effective in the treatment of colorectal liver metastases, with a durable response. It provides local tumor control that enables patients with unresectable metastases to receive further treatme…

Radiological findings of porcine liver after electrochemotherapy with bleomycin Open

Maja Brložnik, Nina Boc, Gregor Serša, Jan Žmuc, Gorana Gašljević , et al. · 2019

Background Radiologic findings after electrochemotherapy of large hepatic blood vessels and healthy hepatic parenchyma have not yet been described. Materials and methods We performed a prospective animal model study with regulatory approva…

Peri-tumoral Metallic Implants Reduce the Efficacy of Irreversible Electroporation for the Ablation of Colorectal Liver Metastases Open

F. Cornélis, Helena Cindrič, Bor Kos, Masashi Fujimori, Elena N. Petre , et al. · 2019

Large Liver Blood Vessels and Bile Ducts Are Not Damaged by Electrochemotherapy with Bleomycin in Pigs Open

Jan Žmuc, Gorana Gašljević, Gregor Serša, Ibrahim Edhemović, Nina Boc , et al. · 2019

Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy Open

Nina Boc, Ibrahim Edhemović, Bor Kos, Maja Marolt Mušič, Erik Brecelj , et al. · 2018

Background The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy of liver tumors to determine the actual ablation zone and to verify the coverage of the treated tumor with a sufficien…

MCNP modelling of the ASPIS Iron88 SINBAD shielding benchmark Open

Bor Kos, Ivan Kodeli · 2018

The report describes the modelling procedure for MCNP of the ASPIS Iron88 shielding benchmark experiment form the SINBAD database. In the first part of the report motivation behind the modelling is given. The report continues with a detail…

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